Mouse

An alternative method for oral drug administration by voluntary intake in male and female mice

Drug administration to experimental rodents is often invasive and stressful, thus reducing animal welfare and potentially confounding experimental results. Methods of oral drug delivery in which rodents cooperate voluntarily minimize stress, pain and morbidity. We herein describe a method for oral...

Year Published: 2021Topics: Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Teixeira-Santos, L., Albino-Teixeira, A., Pinho, D. 2021. An alternative method for oral drug administration by voluntary intake in male and female mice. Laboratory Animals 55(1), 76-80.

Drip, drop…drip, drop – How do I make it stop?

Whether you are an animal care/husbandry technician, facility manager, or veterinarian, everyone bemoans a leaky drinking valve (often referred to as a lixit). Leaking drinking valves and flooded cages are a fairly common problem when using automatic watering systems (or...

Year Published: 2021Topics: Husbandry & ManagementAnimal Type: All/General, Mouse, Rat, Rodent

Citation: Webb, L. 2021. Drip, drop…drip, drop – How do I make it stop? Laboratory Animal Science Professional 9(2) (March/April), 36-38.

Effects of acrylic tunnel enrichment on anxiety-like behavior, neurogenesis, and physiology of C57BL/6J mice

Environmental enrichment for mice lags behind the standard enrichment offered to other laboratory rodents due to concerns about environmental variability and, in specific contexts, aggression. Our objective in this study was to evaluate concerns that the introduction of structural enrichment...

Year Published: 2021Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Oatess, T. L., Harrison, F. E., Himmel, L. E. et al. 2021. Effects of acrylic tunnel enrichment on anxiety-like behavior, neurogenesis, and physiology of C57BL/6J mice. JAALAS 60(1), 44-53.

Compressed paper as an alternative to corn cob bedding in mouse (Mus musculus) cages

Bedding material is a critical component of the mouse environment and affects animal wellbeing and research integrity. Corn cob (CC) bedding has been a common bedding choice in research despite several potential negative aspects of its use. We investigated the...

Year Published: 2020Topics: Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Pallas, B. D., Keys, D. M., Bradley, M. P. et al. 2020. Compressed paper as an alternative to corn cob bedding in mouse (Mus musculus) cages. JAALAS 59(5), 496-502.

A comparison of ketamine or etomidate combined with xylazine for intraperitoneal anesthesia in four mouse strains

Intraperitoneal (IP) injection is a common route of anesthetic administration in mice. Ketamine-xylazine (KX) anesthesia is one of the most widely used IP protocols, but has limitations. Etomidate is an alternative to ketamine that has been used in both human...

Year Published: 2020Topics: Anesthesia & SedationAnimal Type: Mouse, Rodent

Citation: Gergye, C. H., Zhao, Y., Moore, R. et al. 2020. A comparison of ketamine or etomidate combined with xylazine for intraperitoneal anesthesia in four mouse strains. JAALAS 59(5), 519-530.

Comparative effects of 1/4-inch and 1/8-inch corncob bedding on cage ammonia levels, behavior, and respiratory pathology of male C57BL/6 and 129S1/Svlm mice

Corncob is a common bedding material used in laboratory rodents, but little is known about differences in the effects of the 2 available sizes on rodent models and health. This study compared the effects of these 2 corncob bedding sizes...

Year Published: 2020Topics: Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Cantara, S. I., Blas-Machado, U., Zhao, X. et al. 2020. Comparative effects of 1/4-inch and 1/8-inch corncob bedding on cage ammonia levels, behavior, and respiratory pathology of male C57BL/6 and 129S1/Svlm mice. JAALAS 59(6), 695-702.

Identification of sick or dead mice (Mus musculus) housed with 6 grams of crinkle paper nesting material

Although nesting material is beneficial to the welfare of laboratory mice, provision of appropriate amounts may impair visualization of the mice. In anticipation of our academic research institution transitioning to providing 6 grams of nesting material to all mice, we...

Year Published: 2021Topics: Husbandry & Management, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Burlingame, L. A., Gaskill, B. N., Lofgren, J. L. S. 2021. Identification of sick or dead mice (Mus musculus) housed with 6 grams of crinkle paper nesting material. JAALAS 60(1), 18-27.

Effects of compressed paper bedding on mouse breeding performance and recognition of animal health concerns

The combination of bedding substrate and nesting material within the microenvironment of mice is an important consideration for animal care programs in regard to optimizing animal wellbeing. We used 3 general or breeding mouse colonies in our institution to evaluate...

Year Published: 2021Topics: Husbandry & Management, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Allen, P. S., Lawrence, J., Stasula, U. et al. 2021. Effects of compressed paper bedding on mouse breeding performance and recognition of animal health concerns. JAALAS 60(1), 28-36.

Comparison of four beddings for ammonia control in individually ventilated mouse cages

Ammonia control is an important characteristic of rodent bedding materials. Among natural bedding materials, corncob bedding provides excellent ammonia control but contains estrogenic compounds and is ingested by mice. By comparison, processed cellulose bedding products are biologically inert and harbor...

Year Published: 2021Topics: Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Tataryn, N. M., Buckmaster, C. A., Schwiebert, R. et al. 2021. Comparison of four beddings for ammonia control in individually ventilated mouse cages. JAALAS 60(1), 37-43.

Evaluation of nutritional gel supplementation in C57BL/6J mice infected with mouse-adapted Influenza A/PR/8/34 virus

Mice are a common animal model for the study of influenza virus A (IAV). IAV infection causes weight loss due to anorexia and dehydration, which can result in early removal of mice from a study when they reach a humane...

Year Published: 2020Topics: Disease/Experimental Model, Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Felgenhauer, J. L., Brune, J. E., Long, M. E. et al. 2020. Evaluation of nutritional gel supplementation in C57BL/6J mice infected with mouse-adapted Influenza A/PR/8/34 virus. Comparative Medicine 70(6), 471-486.