Mouse

Performance and consistency of circulating warm water blankets for rodents

General anesthesia as used for rodent research can have adverse effects on physiologic mechanisms. Thermoregulation is often greatly inhibited, with resultant deleterious effects on cardiac and respiratory function. These potential effects can be mitigated by providing external heat support. The...

Year Published: 2022Topics: Surgery & Post-OpAnimal Type: Chinchilla, Gerbil, Guinea Pig, Hamster, Mouse, Other Rodent, Rat, Rodent

Citation: Nicolis, I. N., Beale, C. N., Bidot, W. A. et al. 2022. Performance and consistency of circulating warm water blankets for rodents. JAALAS 61(1), 96-100.

Short-term housing in metabolic caging on measures of energy and fluid balance in male C57BL/6J mice (Mus musculus)

Metabolic caging is an important tool for quantitative urine and feces collection in rodents, although significant limitations and problems accompany its use. Despite strong opinions among investigators regarding the effects of metabolic caging on energy and fluid homeostasis, careful quantitative...

Year Published: 2022Topics: HousingAnimal Type: Mouse, Rodent

Citation: Ziegler, A. A., Grobe, C. C., Reho, J. J. et al. 2022. Short-term housing in metabolic caging on measures of energy and fluid balance in male C57BL/6J mice (Mus musculus). JAALAS 61(2), 132-139.

Environmental enrichment for rats and mice housed in laboratories: A metareview

Environmental enrichment has been widely studied in rodents, but there is no consensus on what enrichment should look like or what it should achieve. Inconsistent use of the term “enrichment” creates challenges in drawing conclusions about the quality of an...

Year Published: 2022Topics: Environmental EnrichmentAnimal Type: Mouse, Rat, Rodent

Citation: Ratuski, A. S., Weary, D. M. 2022. Environmental enrichment for rats and mice housed in laboratories: A metareview. Animals 12(4), 414.

Introducing non-aversive mouse handling with ‘squnnels’ in a mouse breeding facility

Based on queries received during our 2021 LASA 3Rs' presentation, we describe operational highlights and concerns that came up during the rollout of nonaversive handling as standard of care at our mouse breeding facility. We describe the development of the...

Year Published: 2022Topics: HandlingAnimal Type: Mouse, Rodent

Citation: Reynolds, P. S. 2022. Introducing non-aversive mouse handling with ‘squnnels' in a mouse breeding facility. Animal Technology and Welfare 21(1), 42-45.

Titrating the preferences of altered lighting against temperature in female CD-1 laboratory mice, Mus musculus

Aspects of the laboratory are aversive to mice, such as being housed under bright lights and at temperatures below their thermal comfort, causing stress and poor welfare. While murine thermal preferences are well understood, light preferences in mice are under...

Year Published: 2022Topics: Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Davis, H. J., Barabas, A. J., Gaskill, B. N. 2022. Titrating the preferences of altered lighting against temperature in female CD-1 laboratory mice, Mus musculus. Applied Animal Behaviour Science 246, 105541.

Why does lifelong conventional housing reduce the sociability of female mice?

Compared to peers raised in well-resourced, 'enriched' environments (‘EE'), female laboratory mice from conventional barren cages are more aggressive to their cage-mates, and less sociable with familiar non-cage-mates (especially if these too are from conventional housing, ‘CH'). But how do...

Year Published: 2022Topics: Housing, Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Kitchenham, L., Nazal, B., Adcock, A. et al. 2022. Why does lifelong conventional housing reduce the sociability of female mice? Applied Animal Behaviour Science 246, 105532.

Effects of multimodal analgesic protocol, with buprenorphine and meloxicam, on mice well-being: A dose finding study

The anesthetic or analgesic agent of choice, route and frequency of anesthetic or analgesic administration, and stressors induce distress during the perioperative period. We evaluated a multimodal analgesic protocol using buprenorphine and meloxicam on the well-being of mice. Twenty-four Slc:ICR...

Year Published: 2021Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Furumoto, K., Ogita, K., Kamisaka, T. et al. 2021. Effects of multimodal analgesic protocol, with buprenorphine and meloxicam, on mice well-being: A dose finding study. Animals 11(12), 3420.

Welfare assessment, end-point refinement and the effects of non-aversive handling in C57BL/6 mice with Lewis lung cancer

Cancer-bearing mice are at risk of developing anxiety, pain, or malaise. These conditions may not only harm welfare but could also undermine data quality and translational validity in studies to develop therapeutic interventions. We aimed to establish whether, or at...

Year Published: 2021Topics: Disease/Experimental Model, Humane Endpoint, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Miller, A. L., Roughan, J. V. 2021. Welfare assessment, end-point refinement and the effects of non-aversive handling in C57BL/6 mice with Lewis lung cancer. Animals 12(1), 23.

Non-invasive assessment of mild stress-induced hyperthermia by infrared thermography in laboratory mice

Stress-induced hyperthermia (SIH) is a physiological response to acute stressors in mammals, shown as an increase in core body temperature, with redirection of blood flow from the periphery to vital organs. Typical temperature assessment methods for rodents are invasive and...

Year Published: 2022Topics: Biological Sampling & Physiological MeasurementAnimal Type: Mouse, Rodent

Citation: Blenkuš, U., Gerós, A. F., Carpinteiro, C. et al. 2022. Non-invasive assessment of mild stress-induced hyperthermia by infrared thermography in laboratory mice. Animals 12(2), 177.

Automated monitoring of respiratory rate as a novel humane endpoint: A refinement in mouse metastatic lung cancer models

In oncology research, while xenograft tumor models are easily visualized and humane endpoints can be clearly defined, metastatic tumor models are often based on more subjective clinical observations as endpoints. This study aimed at identifying objective non-invasive criteria for predicting...

Year Published: 2021Topics: Disease/Experimental Model, Humane EndpointAnimal Type: Mouse, Rodent

Citation: Winn, C. B., Hwang, S. K., Morin, J. et al. 2021. Automated monitoring of respiratory rate as a novel humane endpoint: A refinement in mouse metastatic lung cancer models. PLOS ONE 16(9), e0257694.