Mouse

Effects of supplemental diet during breeding on fertility, litter size, survival rate, and weaning weight in mice (Mus musculus)

The addition of supplemental diets to laboratory animals, specifically rodents, is a common practice for the provision of additional nutritional support. We set out to investigate whether the use of commercially available supplemental diets during breeding affected fertility rate, litter...

Year Published: 2024Topics: Rearing & Weaning, ReproductionAnimal Type: Mouse, Rodent

Citation: Wong, R. K., Carriero, S. J., Wadsworth, B. C. et al. 2024. Effects of supplemental diet during breeding on fertility, litter size, survival rate, and weaning weight in mice (Mus musculus). JAALAS 63(5), 480–487.

Effects of nesting material and housing parameters on feed wastage behavior in female Swiss Webster mice

Feed wastage in laboratory mice, also known as chewing or grinding behavior, is problematic for program management and animal welfare. The destruction of pelleted feed without consumption produces a powder accumulation on the cage floor called orts. Ort accumulation disrupts...

Year Published: 2024Topics: Abnormal/Problematic BehaviorAnimal Type: Mouse, Rodent

Citation: Zawacki, Z. E., Sharpe, J. A., Porco, T. C. et al. 2024. Effects of nesting material and housing parameters on feed wastage behavior in female Swiss Webster mice. JAALAS 63(5), 495–503.

Effects of temporary access to environmental enrichment on measures of laboratory mouse welfare

Laboratory mice are typically housed in “shoebox” cages with limited opportunities to engage in natural behaviour. Temporary access to environments with increased space and complexity (playpens) may improve mouse welfare. Previous work by our group has shown that mice are...

Year Published: 2024Topics: Environmental Enrichment, HousingAnimal Type: Mouse, Rodent

Citation: Ratuski, A. S., Améndola, L., Makowska, I. J. et al. 2024. Effects of temporary access to environmental enrichment on measures of laboratory mouse welfare. Scientific Reports 14(1), 15143.

Effects of intermittent harem mating on parturition-induced stress and success rate of weaning in C57BL/6JNarl mice

Improving the effectiveness of mating schemes for large-scale production of mice is an ongoing challenge in animal facilities. Continuous mating, which requires fewer breeding cages than intermittent mating, has traditionally been used to take advantage of postpartum estrus for efficient...

Year Published: 2024Topics: Rearing & Weaning, ReproductionAnimal Type: Mouse, Rodent

Citation: Chang, T.-K., Wang, C.-H., Lin, T.-Y. et al. 2024. Effects of intermittent harem mating on parturition-induced stress and success rate of weaning in C57BL/6JNarl mice. JAALAS 63(5), 488–494.

Noise and vibration generation and response of mice (Mus musculus) to routine intrafacility transportation methods

Intrafacility transport of mice is an essential function for both laboratory and husbandry personnel. However, transport may induce a stress response that can alter research findings and negatively impact animal welfare. To determine minimally adverse intrafacility transport methods, in-cage noise...

Year Published: 2024Topics: Relocation & TransportAnimal Type: Mouse, Rodent

Citation: Cordingley, J. R., Nemzek, J., Qi, N. 2024. Noise and vibration generation and response of mice (Mus musculus) to routine intrafacility transportation methods. JAALAS 63(3), 221–231.

Guidance on the transport of laboratory animals

Report of the Transport Working Group established by the Laboratory Animal Science Association (LASA)

Year Published: 2005Topics: Relocation & TransportAnimal Type: Amphibian, Cat, Dog, Ferret, Frog & Toad, Guinea Pig, Hamster, Macaque, Marmoset, Mouse, Nonhuman Primate, Pig, Rabbit, Rat, Rodent, Salamander

Citation: Swallow, J., Anderson, D., Buckwell, A. C. et al. 2005. Guidance on the transport of laboratory animals. Laboratory Animals 39(1), 1-39.

Cage-induced stereotypies in female ICR CD-1 mice do not correlate with recurrent perseveration

Stereotypies are repetitive, unvarying, apparently purposeless behavioural patterns. They develop in animals kept in barren environments and are highly prevalent in laboratory mice (Mus musculus), yet their underlying mechanisms have remained elusive. In humans, stereotypies are associated with several psychiatric...

Year Published: 2011Topics: Abnormal/Problematic Behavior, Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Gross, A. N., Engel, A. K. J., Richter, S. H. et al. 2011. Cage-induced stereotypies in female ICR CD-1 mice do not correlate with recurrent perseveration. Behavioural Brain Research 216(2), 613-620.

Assessment of quality of life and wellbeing in mouse preclinical research – A scoping review

Mouse preclinical research is of great scientific interest to understand the mechanisms of human diseases and test potential therapeutic interventions. Researchers characterize biological and physiological traits, behaviors and disease symptoms using standardized phenotypic protocols in the context of in vivo...

Year Published: 2024Topics: Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Sanz-Moreno, A., da Silva-Buttkus, P., Terwee, C. B. et al. 2024. Assessment of quality of life and wellbeing in mouse preclinical research – A scoping review. Neuroscience Applied 3, 104058.

Antinociceptive and cardiorespiratory effects of a single dose of dexmedetomidine in laboratory mice subjected to craniotomy under general anaesthesia with isoflurane and carprofen or meloxicam

Pain refinement represents an important aspect of animal welfare in laboratory animals. Refining analgesia regimens in mice undergoing craniotomy has been sparsely investigated. Here, we sought to investigate the effect of dexmedetomidine in combination with other analgesic drugs on intraoperative...

Year Published: 2024Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Schiele, A. R., Henze, I. S., Bettschart-Wolfensberger, R. et al. 2024. Antinociceptive and cardiorespiratory effects of a single dose of dexmedetomidine in laboratory mice subjected to craniotomy under general anaesthesia with isoflurane and carprofen or meloxicam. Animals 14(6), 913.

Exploring the similarities between risk factors triggering depression in humans and elevated in-cage “inactive but awake” behavior in laboratory mice

Depression is a human mental disorder that can also be inferred in non-human animals. This study explored whether time spent inactive but awake (“IBA”) in the home-cage in mice was further triggered by risk factors similar to those increasing vulnerability...

Year Published: 2024Topics: HousingAnimal Type: Mouse, Rodent

Citation: Schmitt, O., Finnegan, E., Trevarthen, A. et al. 2024. Exploring the similarities between risk factors triggering depression in humans and elevated in-cage “inactive but awake” behavior in laboratory mice. Frontiers in Veterinary Science 11.