Mouse

Locomotor activity as an effective measure of the severity of inflammatory arthritis in a mouse model

Objective Mouse models are valuable in preclinical studies of inflammatory arthritis. However, current methods for measuring disease severity or responses to treatment are not optimal. In this study a smart cage system using multiple sensors to measure locomotor activity was...

Year Published: 2024Topics: Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Doucet, M. R., Laevski, A. M., Doiron, J. A. et al. 2024. Locomotor activity as an effective measure of the severity of inflammatory arthritis in a mouse model. PLOS ONE 19(1), e0291399.

Environmental enrichment improves hippocampus-dependent spatial learning in female C57BL/6 mice in novel IntelliCage sweet reward-based behavioral tests

The IntelliCage is an automated home-cage system that allows researchers to investigate the spontaneous behavior and learning abilities of group-housed mice. The IntelliCage enables us to increase the standardization and reproducibility of behavioral outcomes by the omission of experimenter–mouse interactions....

Year Published: 2023Topics: Animal Training, Behavioral & Cognitive Testing, Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Bramati, G., Stauffer, P., Nigri, M. et al. 2023. Environmental enrichment improves hippocampus-dependent spatial learning in female C57BL/6 mice in novel IntelliCage sweet reward-based behavioral tests. Frontiers in Behavioral Neuroscience 17.

Structural enrichment for laboratory mice: Exploring the effects of novelty and complexity

Providing structural enrichment is a widespread refinement method for laboratory rodents and other animals in captivity. So far, animal welfare research has mostly focused on the effect of increased complexity either by accumulating or combining different enrichment items. However, increasing...

Year Published: 2023Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Bohn, L., Bierbaum, L., Kästner, N. et al. 2023. Structural enrichment for laboratory mice: Exploring the effects of novelty and complexity. Frontiers in Veterinary Science 10.

Comparison of a minimally invasive transthoracic approach and a surgical method for intrapleural injection of tumor cells in mice

Intrapleural injections can be used in mice to deliver therapeutic and diagnostic agents and to model human disease processes (for example, pleural fluid accumulation, malignant pleural disease, and lung cancers). In the context of establishing cancer models, minimally invasive methods...

Year Published: 2023Topics: Disease/Experimental Model, Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Xu, J. J., Lucero, M. Y., Herndon, N. L. et al. 2023. Comparison of a minimally invasive transthoracic approach and a surgical method for intrapleural injection of tumor cells in mice. Comparative Medicine 73(2), 120–126.

PiDose: An open-source system for accurate and automated oral drug administration to group-housed mice

Drug treatment studies in laboratory mice typically employ manual administration methods such as injection or gavage, which can be time-consuming to perform over long periods and cause substantial stress in animals. These stress responses may mask or enhance treatment effects,...

Year Published: 2020Topics: Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Woodard, C. L., Nasrallah, W. B., Samiei, B. V. et al. 2020. PiDose: An open-source system for accurate and automated oral drug administration to group-housed mice. Scientific Reports 10, 11584.

Nest material preference of wild mouse species in laboratory housing

Our research examined the nest-building characteristics of two mouse species native to Hungary, the mound-building mouse (Mus spicilegus) and the house mouse (Mus musculus), under laboratory housing conditions. In indoor housing, the nest-building material plays a very important role in...

Year Published: 2022Topics: Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Bárdos, B., Nagy, I., Gerencsér, Z. et al. 2022. Nest material preference of wild mouse species in laboratory housing. Applied Sciences 12(11), 5750.

BrainWAVE: A flexible method for noninvasive stimulation of brain rhythms across species

Rhythmic neural activity, which coordinates brain regions and neurons to achieve multiple brain functions, is impaired in many diseases. Despite the therapeutic potential of driving brain rhythms, methods to noninvasively target deep brain regions are limited. Accordingly, we recently introduced...

Year Published: 2023Topics: Disease/Experimental ModelAnimal Type: All/General, Mouse, Rodent

Citation: Attokaren, M. K., Jeong, N., Blanpain, L. et al. 2023. BrainWAVE: A flexible method for noninvasive stimulation of brain rhythms across species. ENeuro 10(2) ENEURO.0257-22.2022.

Comparing variability in measurement of subcutaneous tumors in mice using 3D thermal imaging and calipers

Repeatable tumor measurements are key to accurately assessing tumor growth and treatment efficacy. A preliminary study that we conducted showed that a novel 3D and thermal imaging system (3D-TI) for measuring subcutaneous tumors in rodents significantly reduced interoperator variability across...

Year Published: 2022Topics: Disease/Experimental Model, Humane EndpointAnimal Type: Mouse, Rodent

Citation: Brough, D. W., Murkin, J. T., Amos, H. E. et al. 2022. Comparing variability in measurement of subcutaneous tumors in mice using 3D thermal imaging and calipers. Comparative Medicine 72(6), 364–375.

A new tool for quantifying mouse facial expressions

Facial expressions are an increasingly used tool to assess emotional experience and affective state during experimental procedures in animal models. Previous studies have successfully related specific facial features with different positive and negative valence situations, most notably in relation to...

Year Published: 2023Topics: Emotion, Pain, & Sentience, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Moëne, O. L., Larsson, M. 2023. A new tool for quantifying mouse facial expressions. ENeuro 10(2) ENEURO.0349-22.2022.

Conventional laboratory housing increases morbidity and mortality in research rodents: Results of a meta-analysis

Over 120 million mice and rats are used annually in research, conventionally housed in shoebox-sized cages that restrict natural behaviours (e.g. nesting and burrowing). This can reduce physical fitness, impair thermoregulation and reduce welfare (e.g. inducing abnormal stereotypic behaviours). In...

Year Published: 2022Topics: Disease/Experimental Model, Environmental Enrichment, HousingAnimal Type: Mouse, Rat, Rodent

Citation: Cait, J., Cait, A., Scott, R. W. et al. 2022. Conventional laboratory housing increases morbidity and mortality in research rodents: Results of a meta-analysis. BMC Biology 20(1), 15.