Mouse

The 3Rs in experimental liver disease

Patients with cirrhosis present multiple physiological and immunological alterations that play a very important role in the development of clinically relevant secondary complications to the disease. Experimentation in animal models is essential to understand the pathogenesis of human diseases and,...

Year Published: 2023Topics: Disease/Experimental ModelAnimal Type: All/General, Mouse, Rat, Rodent

Citation: Martinez-Lopez, S., Angel-Gomis, E., Sanchez-Ardid, E. et al. 2023. The 3Rs in experimental liver disease. Animals 13(14), 2357.

A field-based adaptation of the classic morris water maze to assess learning and memory in a free-living animal

Free-living animals rely on cognitive functions, such as learning and memory, for numerous aspects of their survival. However, research involving these mechanisms is often limited to the laboratory where animals are far removed from natural influences. Here, we adapted the...

Year Published: 2020Topics: Behavioral & Cognitive TestingAnimal Type: Mouse, Rodent

Citation: McKay, L., Hunninck, L., Sheriff, M. 2020. A field-based adaptation of the classic morris water maze to assess learning and memory in a free-living animal. Animal Behavior and Cognition 9(4), 396–407.

Refinement of animal experiments: Replacing traumatic methods of laboratory animal marking with non-invasive alternatives

Reliable methods for identifying rodents play an important role in ensuring the success of preclinical studies. However, animal identification remains a trivial laboratory routine that is not often discussed, despite the fact that more than 6 million rodents are used...

Year Published: 2023Topics: Identification MethodAnimal Type: Mouse, Rat, Rodent

Citation: Klabukov, I., Shestakova, V., Krasilnikova, O. et al. 2023. Refinement of animal experiments: Replacing traumatic methods of laboratory animal marking with non-invasive alternatives. Animals 13(22), 3452.

Using photographs for rating severity degrees of clinical appearance in research mice enables valid discrimination of extreme but not mild and moderate conditions: A pilot study

To ensure good animal welfare in laboratory research and in stockbreeding severity ratings of the animals´ wellbeing are essential. The current study investigated how valid raters can evaluate different severity degrees of clinical appearance and how ratings might be influenced...

Year Published: 2023Topics: Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: rueger, J. C., Boecker, M., Gauggel, S. et al. 2023. Using photographs for rating severity degrees of clinical appearance in research mice enables valid discrimination of extreme but not mild and moderate conditions: A pilot study. PLOS ONE 18(11), e0287965.

Challenges and advanced concepts for the assessment of learning and memory function in mice

The mechanisms underlying the formation and retrieval of memories are still an active area of research and discussion. Manifold models have been proposed and refined over the years, with most assuming a dichotomy between memory processes involving non-conscious and conscious...

Year Published: 2023Topics: Behavioral & Cognitive TestingAnimal Type: Mouse, Rodent

Citation: Lang, B., Kahnau, P., Hohlbaum, K. et al. 2023. Challenges and advanced concepts for the assessment of learning and memory function in mice. Frontiers in Behavioral Neuroscience 17.

Social context increases ultrasonic vocalizations during restraint in adult mice

Adult mice emit many ultrasonic vocalizations (USVs) during social interaction tasks, but only a few studies have yet reported USVs in stressed adult mice. Our aim was to study which experimental conditions favor USV emission during behaviors associated with different...

Year Published: 2020Topics: Restraint, Social Housing & Companionship, VocalizationAnimal Type: Mouse, Rodent

Citation: Lefebvre, E., Granon, S., Chauveau, F. 2020. Social context increases ultrasonic vocalizations during restraint in adult mice. Animal Cognition 23(2), 351–359.

Moving away from soiled bedding sentinels—The (R)evolution in rodent health screening

Traditional health monitoring methods consist of Soiled Bedding Sentinels (SBS), with animals exposed to dirty bedding from colony animals, which require the euthanasia of SBS. Numerous studies have demonstrated that SBS may not accurately represent a colony's health status. During...

Year Published: 2023Topics: Biological Sampling & Physiological MeasurementAnimal Type: Mouse, Rat, Rodent

Citation: Esparza, K. 2023. Moving away from soiled bedding sentinels—The (R)evolution in rodent health screening. Animal Technology and Welfare 22(2), 158–160.

Daily replacement of very high-fat diet stabilizes food intake and improves mouse welfare by ensuring food quality

Researchers are obligated to ensure food quality and provide laboratory animals with a palatable diet. Factors influencing the quality and palatability of very high-fat diet (VHFD), a widely used rodent diet, however, are understudied. We conducted experiments to establish best...

Year Published: 2023Topics: Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Cordeira, J. 2023. Daily replacement of very high-fat diet stabilizes food intake and improves mouse welfare by ensuring food quality. PLOS ONE 18(9), e0291347.

Effect of environmental exposure to a maternally-learned odorant on anxiety-like behaviors at weaning in mice

Early sensory experience, such as exposure to maternal or other environmental factors, is considered to influence neurocognitive development and behaviors. In many species, exposure to odorants during pregnancy or lactation impacts the morpho-functional development of the olfactory circuitry with changes...

Year Published: 2020Topics: Emotion, Pain, & Sentience, Environmental Enrichment, Rearing & WeaningAnimal Type: Mouse, Rodent

Citation: Dewaele, A., Badonnel, K., Persuy, M.-A. et al. 2020. Effect of environmental exposure to a maternally-learned odorant on anxiety-like behaviors at weaning in mice. Animal Cognition 23(5), 881–891.

Nesting behavior is associated with body weight and grip strength loss in mice suffering from experimental arthritis

Objective animal health evaluation is essential to determine welfare and discomfort in preclinical in vivo research. Body condition scores, body weight, and grimace scales are commonly used to evaluate well-being in murine rheumatoid arthritis (RA) and osteoarthritis experiments. However, nest-building,...

Year Published: 2023Topics: Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Dietrich, T., Aigner, A., Hildebrandt, A. et al. 2023. Nesting behavior is associated with body weight and grip strength loss in mice suffering from experimental arthritis. Scientific Reports 13(1), 23087.