Mouse

The hard-hitting tooth—Does a scheduled teeth check reduce the number of mice found dead with malocclusion?

Malocclusion is a common dental disorder for laboratory mice. Characterised with improper alignment of teeth, if the incisors of the mouse have become overgrown or are missing it can significantly impact animal welfare. Malocclusion is evident around the first 2-5...

Year Published: 2023Topics: Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Ciupa, J. 2023. The hard-hitting tooth—Does a scheduled teeth check reduce the number of mice found dead with malocclusion? Animal Technology and Welfare 22(3), 240–241.

To wheel or not to wheel

Our study into the implementation of running wheels in overweight prone strains of mice and the potential integration of this practice into our mouse protocols.

Year Published: 2023Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Ives, P., Caygill, J. 2023. To wheel or not to wheel. Animal Technology and Welfare 22(3), 246–247.

Tamoxifen exacerbates morbidity and mortality in male mice receiving medetomidine anaesthesia

Tamoxifen-induced CreER-LoxP recombination is often used to induce spatiotemporally controlled gene deletion in genetically modified mice. Prior work has shown that tamoxifen and tamoxifen-induced CreER activation can have off-target effects that should be controlled. However, it has not yet been...

Year Published: 2023Topics: Anesthesia & Sedation, Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Rashbrook, V. S., Denti, L., Ruhrberg, C. 2023. Tamoxifen exacerbates morbidity and mortality in male mice receiving medetomidine anaesthesia. Animal Welfare 32, e78.

Refining the welfare of immunocompromised mice receiving carbon tetrachloride (CCI4) to induce liver fibrosis

Our method provides evidence that we can alter CCI4 dosing and implement recovery techniques to enhance Animal Welfare, whilst maintaining sufficient levels of fibrosis in the liver.

Year Published: 2023Topics: Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Walczak-Gillies, Matthews, O., Fyfe, A. et al. 2023. Refining the welfare of immunocompromised mice receiving carbon tetrachloride (CCI4) to induce liver fibrosis. Animal Technology and Welfare 22(3), 237–239.

Evaluation of cage mate–induced postsurgical trauma in mice

Although mice are social animals, individual housing is sometimes requested after surgery. We questioned whether pair-housing mice after surgery resulted in greater trauma to the surgical site as compared with single housing. We further evaluated the effect of individual housing...

Year Published: 2023Topics: Social Housing & Companionship, Surgery & Post-OpAnimal Type: Mouse, Rodent

Citation: Tirado-Muñiz, N., Spangler, T. L., Van Rooyen, H. et al. 2023. Evaluation of cage mate–induced postsurgical trauma in mice. JAALAS 62(2), 170–178.

Comparison of systemic extended-release buprenorphine and local extended-release bupivacaine-meloxicam as analgesics for laparotomy in mice

Extended-release (ER) local anesthetics can be used in multi-modal analgesia or in situations in which systemic analgesics may alter animal physiology and thus introduce interpretational confounds. In this study, we compared the analgesic efficacy of an ER buprenorphine formulation with...

Year Published: 2023Topics: Analgesia, Surgery & Post-OpAnimal Type: Mouse, Rodent

Citation: Yang, P., Hish, G., Lester, P. A. 2023. Comparison of systemic extended-release buprenorphine and local extended-release bupivacaine-meloxicam as analgesics for laparotomy in mice. JAALAS 62(5), 416–422.

Effects of breeding configuration on maternal and weanling behavior in laboratory mice

Although numerous studies have evaluated the effect of housing density on the wellbeing of laboratory mice, little is known about the effect of breeding configuration on mouse behavior. The 8th edition of the Guide for the Care and Use of...

Year Published: 2017Topics: ReproductionAnimal Type: Mouse, Rodent

Citation: Braden, G. C., Rasmussen, S., Monette, S. et al. 2017. Effects of breeding configuration on maternal and weanling behavior in laboratory mice. JAALAS 56(4), 369-376.

Mouse isoflurane anesthesia using the drop method

Anesthesia with isoflurane prior to carbon dioxide euthanasia is recommended as a refinement, but vaporizer access can be limited. An alternative to vaporizers is the ‘drop' method, introducing a fixed volume of isoflurane into the induction chamber. Previous work suggests...

Year Published: 2023Topics: Anesthesia & Sedation, EuthanasiaAnimal Type: Mouse, Rodent

Citation: Bodnar, M. J., Ratuski, A. S., Weary, D. M. 2023. Mouse isoflurane anesthesia using the drop method. Laboratory Animals 57(6), 623–630.

Determining the preferred liquid reward in adult C57BL/6 mice

Using food rewards to motivate mice is commonplace in behavioural research. Using a reward which is highly desirable is of benefit, as it can reduce the need to food restrict animals and can encourage higher levels of consumption, allowing for...

Year Published: 2023Topics: Behavioral & Cognitive Testing, Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Miller, A. L., Leach, M. C. 2023. Determining the preferred liquid reward in adult C57BL/6 mice. Laboratory Animals 57(3), 332–335.

A minimally invasive bronchoscopic approach for direct delivery to murine airways and application to models of pulmonary infection

The laboratory mouse is used extensively for human disease modeling and preclinical therapeutic testing for efficacy, biodistribution, and toxicity. The variety of murine models available, and the ability to create new ones, eclipses all other species, but the size of...

Year Published: 2023Topics: Cannulation, Catheterization, & Intubation, Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Schelde, K., Rosenjack, J., Sonneborn, C. et al. 2023. A minimally invasive bronchoscopic approach for direct delivery to murine airways and application to models of pulmonary infection. Laboratory Animals 57(6), 611–622.