Mouse

What N Is N-ough for MRI-based animal neuroimaging? eNeuro 11(3), ENEURO

Fueled by the recent and controversial brain-wide association studies in humans, the animal neuroimaging community has also begun questioning whether using larger sample sizes is necessary for ethical and effective scientific progress. In this opinion piece, we illustrate two opposing...

Year Published: 2024Topics: Imaging & Electrophysiological RecordingAnimal Type: All/General, Mouse, Rat, Rodent

Citation: Grandjean, J., Lake, E. M. R., Pagani, M. et al. 2024. What N Is N-ough for MRI-based animal neuroimaging? eNeuro 11(3), ENEURO.0531-23.2024.

Development and implementation of a Dependable, Simple, and Cost-effective (DSC), open-source running wheel in High Drinking in the Dark and Heterogeneous Stock/Northport mice

Maintaining healthy and consistent levels of physical activity (PA) is a clinically proven and low-cost means of reducing the onset of several chronic diseases and may provide an excellent strategy for managing mental health and related outcomes. Wheel-running (WR) is...

Year Published: 2024Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Grigsby, K., Usmani, Z., Anderson, J. et al. 2024. Development and implementation of a Dependable, Simple, and Cost-effective (DSC), open-source running wheel in High Drinking in the Dark and Heterogeneous Stock/Northport mice. Frontiers in Behavioral Neuroscience 17.

A 3D-printed dummy for training distal phalanx amputation in mice

The development of realistic dummies for training the distal phalanx amputation (DPA) technique in mouse pups is a promising alternative to reduce and replace animals in training for research and teaching. To test this, we obtained micro-CT data from postnatal...

Year Published: 2024Topics: Identification MethodAnimal Type: Mouse, Rodent

Citation: Heuser, M., Gonzalez-Uarquin, F., Nuber, M. et al. 2024. A 3D-printed dummy for training distal phalanx amputation in mice. Animals 14(8), 1253.

IntelliCage: The development and perspectives of a mouse- and user-friendly automated behavioral test system

IntelliCage for mice is a rodent home-cage equipped with four corner structures harboring symmetrical double panels for operant conditioning at each of the two sides, either by reward (access to water) or by aversion (non-painful stimuli: air-puffs, LED lights). Corner...

Year Published: 2024Topics: HousingAnimal Type: Mouse, Rodent

Citation: Lipp, H.-P., Krackow, S., Turkes, E. et al. 2024. IntelliCage: The development and perspectives of a mouse- and user-friendly automated behavioral test system. Frontiers in Behavioral Neuroscience 17.

Recommendations for measuring and standardizing light for laboratory mammals to improve welfare and reproducibility in animal research

Light enables vision and exerts widespread effects on physiology and behavior, including regulating circadian rhythms, sleep, hormone synthesis, affective state, and cognitive processes. Appropriate lighting in animal facilities may support welfare and ensure that animals enter experiments in an appropriate...

Year Published: 2024Topics: Husbandry & ManagementAnimal Type: All/General, Cat, Dog, Goat, Macaque, Marmoset, Mouse, Nonhuman Primate, Pig, Rat, Rodent, Sheep, Vervet (African Green Monkey)

Citation: Lucas, R. J., Allen, A. E., Brainard, G. C. et al. 2024. Recommendations for measuring and standardizing light for laboratory mammals to improve welfare and reproducibility in animal research. PLOS Biology 22(3), e3002535.

Humane endpoints in Swiss Webster mice infected with Toxoplasma gondii RH strain

The highly virulent Toxoplasma gondii RH strain is maintained through successive passages in mice, but there is still a lack of studies that refine these procedures from a 3Rs perspective, where humanitarian ideals aim to minimize the stress, pain, or...

Year Published: 2024Topics: Humane EndpointAnimal Type: Mouse, Rodent

Citation: Arruda, I. F., Amendoeira, M. R. R., Bonifácio, T. F. et al. 2024. Humane endpoints in Swiss Webster mice infected with Toxoplasma gondii RH strain. Animals 14(9), 1326.

Impact of enriched environment on motor performance and learning in mice

Neuroscience heavily relies on animal welfare in laboratory rodents as it can significantly affect brain development, cognitive function and memory formation. Unfortunately, laboratory animals are often raised in artificial environments devoid of physical and social stimuli, potentially leading to biased...

Year Published: 2024Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Dijkhuizen, S., Van Ginneken, L. M. C., IJpelaar, A. H. C. et al. 2024. Impact of enriched environment on motor performance and learning in mice. Scientific Reports 14(1), 5962.

Make training easier with a scruffing restraint device

If you conduct technical training with mice at your institution, a scruffing restraint device is a valuable addition to your training aid tool kit. A scruffing restraint device, such as the ScruffGuard offered by Research Devices, is a small, simple...

Year Published: 2024Topics: RestraintAnimal Type: Mouse, Rodent

Citation: Benjamin, K. 2024. Make training easier with a scruffing restraint device. Laboratory Animal Science Professional 12(2) (March/April), 38-39.

Carprofen attenuates postoperative mechanical and thermal hypersensitivity after plantar incision in immunodeficient NSG mice

Immunodeficient NSG mice are reported to be less responsive to buprenorphine analgesia. Here, we used NSG mice to compare the efficacy of the commonly used dose of carprofen (5 mg/kg) with 5 and 10 times that dose (25 and 50...

Year Published: 2024Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Alamaw, E. D., Casey, K. M., Tien, K. et al. 2024. Carprofen attenuates postoperative mechanical and thermal hypersensitivity after plantar incision in immunodeficient NSG mice. Comparative Medicine 74(2), 105–114.

Differences in fluid, electrolyte, and energy balance in C57BL/6J mice (Mus musculus) in metabolic caging at thermoneutral or standard room temperatures

The Guide for the Care and Use of Laboratory Animals recommends mice be pair or group housed and provided with nesting materials. These provisions support social interactions and are also critical for thermoregulatory behaviors such as huddling and burrowing. However,...

Year Published: 2024Topics: Biological Sampling & Physiological Measurement, Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Lawton, S. B., Grobe, C. C., Reho, J. J. et al. 2024. Differences in fluid, electrolyte, and energy balance in C57BL/6J mice (Mus musculus) in metabolic caging at thermoneutral or standard room temperatures. JAALAS 63(2), 190–200.