Mouse

Effects of intermittent harem mating on parturition-induced stress and success rate of weaning in C57BL/6JNarl mice

Improving the effectiveness of mating schemes for large-scale production of mice is an ongoing challenge in animal facilities. Continuous mating, which requires fewer breeding cages than intermittent mating, has traditionally been used to take advantage of postpartum estrus for efficient...

Year Published: 2024Topics: Rearing & Weaning, ReproductionAnimal Type: Mouse, Rodent

Citation: Chang, T.-K., Wang, C.-H., Lin, T.-Y. et al. 2024. Effects of intermittent harem mating on parturition-induced stress and success rate of weaning in C57BL/6JNarl mice. JAALAS 63(5), 488–494.

Noise and vibration generation and response of mice (Mus musculus) to routine intrafacility transportation methods

Intrafacility transport of mice is an essential function for both laboratory and husbandry personnel. However, transport may induce a stress response that can alter research findings and negatively impact animal welfare. To determine minimally adverse intrafacility transport methods, in-cage noise...

Year Published: 2024Topics: Relocation & TransportAnimal Type: Mouse, Rodent

Citation: Cordingley, J. R., Nemzek, J., Qi, N. 2024. Noise and vibration generation and response of mice (Mus musculus) to routine intrafacility transportation methods. JAALAS 63(3), 221–231.

Guidance on the transport of laboratory animals

Report of the Transport Working Group established by the Laboratory Animal Science Association (LASA)

Year Published: 2005Topics: Relocation & TransportAnimal Type: Amphibian, Cat, Dog, Ferret, Frog & Toad, Guinea Pig, Hamster, Macaque, Marmoset, Mouse, Nonhuman Primate, Pig, Rabbit, Rat, Rodent, Salamander

Citation: Swallow, J., Anderson, D., Buckwell, A. C. et al. 2005. Guidance on the transport of laboratory animals. Laboratory Animals 39(1), 1-39.

Cage-induced stereotypies in female ICR CD-1 mice do not correlate with recurrent perseveration

Stereotypies are repetitive, unvarying, apparently purposeless behavioural patterns. They develop in animals kept in barren environments and are highly prevalent in laboratory mice (Mus musculus), yet their underlying mechanisms have remained elusive. In humans, stereotypies are associated with several psychiatric...

Year Published: 2011Topics: Abnormal/Problematic Behavior, Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Gross, A. N., Engel, A. K. J., Richter, S. H. et al. 2011. Cage-induced stereotypies in female ICR CD-1 mice do not correlate with recurrent perseveration. Behavioural Brain Research 216(2), 613-620.

Assessment of quality of life and wellbeing in mouse preclinical research – A scoping review

Mouse preclinical research is of great scientific interest to understand the mechanisms of human diseases and test potential therapeutic interventions. Researchers characterize biological and physiological traits, behaviors and disease symptoms using standardized phenotypic protocols in the context of in vivo...

Year Published: 2024Topics: Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Sanz-Moreno, A., da Silva-Buttkus, P., Terwee, C. B. et al. 2024. Assessment of quality of life and wellbeing in mouse preclinical research – A scoping review. Neuroscience Applied 3, 104058.

Antinociceptive and cardiorespiratory effects of a single dose of dexmedetomidine in laboratory mice subjected to craniotomy under general anaesthesia with isoflurane and carprofen or meloxicam

Pain refinement represents an important aspect of animal welfare in laboratory animals. Refining analgesia regimens in mice undergoing craniotomy has been sparsely investigated. Here, we sought to investigate the effect of dexmedetomidine in combination with other analgesic drugs on intraoperative...

Year Published: 2024Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Schiele, A. R., Henze, I. S., Bettschart-Wolfensberger, R. et al. 2024. Antinociceptive and cardiorespiratory effects of a single dose of dexmedetomidine in laboratory mice subjected to craniotomy under general anaesthesia with isoflurane and carprofen or meloxicam. Animals 14(6), 913.

Exploring the similarities between risk factors triggering depression in humans and elevated in-cage “inactive but awake” behavior in laboratory mice

Depression is a human mental disorder that can also be inferred in non-human animals. This study explored whether time spent inactive but awake (“IBA”) in the home-cage in mice was further triggered by risk factors similar to those increasing vulnerability...

Year Published: 2024Topics: HousingAnimal Type: Mouse, Rodent

Citation: Schmitt, O., Finnegan, E., Trevarthen, A. et al. 2024. Exploring the similarities between risk factors triggering depression in humans and elevated in-cage “inactive but awake” behavior in laboratory mice. Frontiers in Veterinary Science 11.

The impact of cage dividers on mouse aggression, dominance and hormone levels

Home cage aggression in group-housed male mice is a major welfare concern and may compromise animal research. Conventional cages prevent flight or retreat from sight, increasing the risk that agonistic encounters will result in injury. Moreover, depending on social rank,...

Year Published: 2024Topics: Housing, Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Streiff, C., Herrera, A., Voelkl, B. et al. 2024. The impact of cage dividers on mouse aggression, dominance and hormone levels. PLOS ONE 19(2), e0297358.

Bite wounds and dominance structures in male and female African spiny mice (Acomys cahirinus): Implications for animal welfare and the generalizability of experimental results

Bite wounds due to aggression in male laboratory mice (Mus musculus) are a major welfare concern, often leading to attrition, chronic activation of the innate immune system, and significant impacts on the experimental results derived from the use of these...

Year Published: 2024Topics: Abnormal/Problematic BehaviorAnimal Type: Mouse, Rodent

Citation: Varholick, J. A., Godinez, G., Jenkins, A. et al. 2024. Bite wounds and dominance structures in male and female African spiny mice (Acomys cahirinus): Implications for animal welfare and the generalizability of experimental results. Animals 14(1), 64.

Improved memory and lower stress levels in male mice co-housed with ovariectomized female mice

Aggressiveness, expressed by fighting, is a frequent problem in group-housed laboratory male mice and results in increased stress, injury, and death. One way to prevent fighting is by pairing the male mice with ovariectomized female mice to provide a compatible...

Year Published: 2024Topics: Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Wikanthi, L. S. S., Forsström, J., Ewaldsson, B. et al. 2024. Improved memory and lower stress levels in male mice co-housed with ovariectomized female mice. Animals 14(10), 1503.