Mouse

Effects of experimental housing conditions on recovery of laboratory mice

The beneficial effects of environment and social support during disease recovery in humans are widely accepted. Because laboratory mice are social animals and are highly motivated to interact with each other and with their environment, it is very likely that...

Year Published: 2015Topics: Environmental Enrichment, Social Housing & Companionship, Surgery & Post-OpAnimal Type: Mouse, Rodent

Citation: Jirkof, P. 2015. Effects of experimental housing conditions on recovery of laboratory mice. Lab Animal 44(2), 65-70.

Group housing and nest building only slightly ameliorate the cold stress of typical housing in female C57BL/6J mice

Huddling and nest building are two methods of behavioral thermoregulation used by mice under cold stress. In the laboratory, mice are typically housed at an ambient temperature (Ta) of 20°C, well below the lower end of their thermoneutral zone. We...

Year Published: 2015Topics: Environmental Enrichment, Housing, Husbandry & Management, Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Maher, R. L., Barbash, S. M., Lynch, D. V. et al. 2015. Group housing and nest building only slightly ameliorate the cold stress of typical housing in female C57BL/6J mice. American Journal of Physiology 308(12), R1070-R1079.

Laboratory animal behavior

The study of laboratory animal behavior has increased steadily over the last decade, with expanding emphasis on a variety of commonly used species. In the United States, this trend was initially focused on species for which there was a regulatory...

Year Published: 2015Topics: Abnormal/Problematic Behavior, Environmental Enrichment, Housing, Human-Animal Interaction, Social Housing & CompanionshipAnimal Type: Baboon, Bird, Capuchin, Cat, Cattle, Chicken, Chimpanzee, Dog, Fowl, Gerbil, Goat, Guinea Pig, Hamster, Lemur, Macaque, Marmoset, Mink, Mouse, Other Nonhuman Primate, Owl Monkey, Rabbit, Rat, Rodent, Sheep, Squirrel Monkey, Vervet (African Green Monkey)

Citation: Bayne, K. A., Beaver, B. V., Mench, J. A. et al. 2015. Laboratory animal behavior. In: Laboratory Animal Medicine, 3rd edition. Fox, J. G., Anderson, L., Otto, G., et al. (eds). Elsevier, Inc., Amsterdam, NL. pp. 1617-1651.

Impact of inhalation anaesthesia, surgery and analgesic treatment on home cage behaviour in laboratory mice

Anaesthesia and analgesia are used frequently in laboratory routine to ensure animal welfare and good scientific outcomes in experiments that may elicit pain or require immobilisation of the animal. However, there is concern regarding the effect of these procedures on...

Year Published: 2014Topics: Analgesia, Anesthesia & Sedation, Surgery & Post-OpAnimal Type: Mouse, Rodent

Citation: Cesarovic, N., Arras, M., Jirkof, P. 2014. Impact of inhalation anaesthesia, surgery and analgesic treatment on home cage behaviour in laboratory mice. Applied Animal Behaviour Science. 157, 137-145.

The power of automated behavioural homecage technologies in characterizing disease progression in laboratory mice: A review

Behavioural changes that occur as animals become sick have been characterized in a number of species and include the less frequent occurrence of ‘luxury behaviours' such as playing, grooming and socialization. ‘Sickness behaviours' or behavioural changes following exposure to infectious...

Year Published: 2015Topics: Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Richardson, C. A. 2015. The power of automated behavioural homecage technologies in characterizing disease progression in laboratory mice: A review. Applied Animal Behaviour Science 163, 19-27.

Testing three measures of mouse insensibility following induction with isoflurane or carbon dioxide gas for a more humane euthanasia

Laboratory mice are commonly killed via exposure to gradually increasing concentrations of isoflurane and carbon dioxide (CO2) gas. Once rendered insensible using isoflurane or CO2, a high concentration of CO2 is used to decrease time to death. When the switch...

Year Published: 2015Topics: EuthanasiaAnimal Type: Mouse, Rodent

Citation: Moody, C. M., Makowska, I. J., Weary, D. M. 2015. Testing three measures of mouse insensibility following induction with isoflurane or carbon dioxide gas for a more humane euthanasia. Applied Animal Behaviour Science 163, 183-87.

Aspen shaving versus chip bedding: Effects on breeding and behavior

The choice of laboratory cage bedding material is often based on both practical and husbandry issues, whereas behavioral outcomes rarely appear to be considered. It has been noted that a breeding success difference appears to be associated with the differential...

Year Published: 2015Topics: Husbandry & Management, ReproductionAnimal Type: Mouse, Rodent

Citation: Jackson, E., Demarest, K., Eckert, W. J. et al. 2015. Aspen shaving versus chip bedding: Effects on breeding and behavior. Laboratory Animals 49(1), 46-56.

The effect of isoflurane anaesthesia and buprenorphine on the mouse grimace scale and behaviour in CBA and DBA/2 mice

Prevention or alleviation of pain in laboratory mice is a fundamental requirement of in vivoresearch. The mouse grimace scale (MGS) has the potential to be an effective and rapid means of assessing pain and analgesic efficacy in laboratory mice. Preliminary...

Year Published: 2015Topics: Analgesia, Anesthesia & Sedation, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Miller, A., Kitson, G., Skalkoyannis, B. et al. 2015. The effect of isoflurane anaesthesia and buprenorphine on the mouse grimace scale and behaviour in CBA and DBA/2 mice. Applied Animal Behaviour Science 172, 58-62.

Long-term provision of environmental resources alters behavior but not physiology or neuroanatomy of male and female BALB/c and C57BL/6 mice

Few studies have evaluated the long-term effects of providing environmental resources to mice. This consideration is important given that mice are often maintained in vivaria for months. We evaluated the effects of providing simple cage resources (wood wool, cotton nesting...

Year Published: 2015Topics: Environmental Enrichment, Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Clipperton-Allen, A. E., Ingrao, J. C., Ruggerio, L. et al. 2015. Long-term provision of environmental resources alters behavior but not physiology or neuroanatomy of male and female BALB/c and C57BL/6 mice. JAALAS 54(6), 718-30.

Effect of enrichment devices on aggression in manipulated nude mice

Agonistic behavior in group-housed male mice is a recurring problem in many animal research facilities. Common management procedures, such as the removal of aggressors, are moderately successful but often fail, owing to recurrence of aggressive behavior among cagemates. Studies have...

Year Published: 2015Topics: Environmental Enrichment, Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Lockworth, C. R., Kim, S., Liu, J. et al. 2015. Effect of enrichment devices on aggression in manipulated nude mice. JAALAS 54(6), 731-736.