Mouse

Assessment of quality of life and wellbeing in mouse preclinical research – A scoping review

Mouse preclinical research is of great scientific interest to understand the mechanisms of human diseases and test potential therapeutic interventions. Researchers characterize biological and physiological traits, behaviors and disease symptoms using standardized phenotypic protocols in the context of in vivo...

Year Published: 2024Topics: Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Sanz-Moreno, A., da Silva-Buttkus, P., Terwee, C. B. et al. 2024. Assessment of quality of life and wellbeing in mouse preclinical research – A scoping review. Neuroscience Applied 3, 104058.

Antinociceptive and cardiorespiratory effects of a single dose of dexmedetomidine in laboratory mice subjected to craniotomy under general anaesthesia with isoflurane and carprofen or meloxicam

Pain refinement represents an important aspect of animal welfare in laboratory animals. Refining analgesia regimens in mice undergoing craniotomy has been sparsely investigated. Here, we sought to investigate the effect of dexmedetomidine in combination with other analgesic drugs on intraoperative...

Year Published: 2024Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Schiele, A. R., Henze, I. S., Bettschart-Wolfensberger, R. et al. 2024. Antinociceptive and cardiorespiratory effects of a single dose of dexmedetomidine in laboratory mice subjected to craniotomy under general anaesthesia with isoflurane and carprofen or meloxicam. Animals 14(6), 913.

Exploring the similarities between risk factors triggering depression in humans and elevated in-cage “inactive but awake” behavior in laboratory mice

Depression is a human mental disorder that can also be inferred in non-human animals. This study explored whether time spent inactive but awake (“IBA”) in the home-cage in mice was further triggered by risk factors similar to those increasing vulnerability...

Year Published: 2024Topics: HousingAnimal Type: Mouse, Rodent

Citation: Schmitt, O., Finnegan, E., Trevarthen, A. et al. 2024. Exploring the similarities between risk factors triggering depression in humans and elevated in-cage “inactive but awake” behavior in laboratory mice. Frontiers in Veterinary Science 11.

The impact of cage dividers on mouse aggression, dominance and hormone levels

Home cage aggression in group-housed male mice is a major welfare concern and may compromise animal research. Conventional cages prevent flight or retreat from sight, increasing the risk that agonistic encounters will result in injury. Moreover, depending on social rank,...

Year Published: 2024Topics: Housing, Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Streiff, C., Herrera, A., Voelkl, B. et al. 2024. The impact of cage dividers on mouse aggression, dominance and hormone levels. PLOS ONE 19(2), e0297358.

Bite wounds and dominance structures in male and female African spiny mice (Acomys cahirinus): Implications for animal welfare and the generalizability of experimental results

Bite wounds due to aggression in male laboratory mice (Mus musculus) are a major welfare concern, often leading to attrition, chronic activation of the innate immune system, and significant impacts on the experimental results derived from the use of these...

Year Published: 2024Topics: Abnormal/Problematic BehaviorAnimal Type: Mouse, Rodent

Citation: Varholick, J. A., Godinez, G., Jenkins, A. et al. 2024. Bite wounds and dominance structures in male and female African spiny mice (Acomys cahirinus): Implications for animal welfare and the generalizability of experimental results. Animals 14(1), 64.

Improved memory and lower stress levels in male mice co-housed with ovariectomized female mice

Aggressiveness, expressed by fighting, is a frequent problem in group-housed laboratory male mice and results in increased stress, injury, and death. One way to prevent fighting is by pairing the male mice with ovariectomized female mice to provide a compatible...

Year Published: 2024Topics: Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Wikanthi, L. S. S., Forsström, J., Ewaldsson, B. et al. 2024. Improved memory and lower stress levels in male mice co-housed with ovariectomized female mice. Animals 14(10), 1503.

What N Is N-ough for MRI-based animal neuroimaging? eNeuro 11(3), ENEURO

Fueled by the recent and controversial brain-wide association studies in humans, the animal neuroimaging community has also begun questioning whether using larger sample sizes is necessary for ethical and effective scientific progress. In this opinion piece, we illustrate two opposing...

Year Published: 2024Topics: Imaging & Electrophysiological RecordingAnimal Type: All/General, Mouse, Rat, Rodent

Citation: Grandjean, J., Lake, E. M. R., Pagani, M. et al. 2024. What N Is N-ough for MRI-based animal neuroimaging? eNeuro 11(3), ENEURO.0531-23.2024.

Development and implementation of a Dependable, Simple, and Cost-effective (DSC), open-source running wheel in High Drinking in the Dark and Heterogeneous Stock/Northport mice

Maintaining healthy and consistent levels of physical activity (PA) is a clinically proven and low-cost means of reducing the onset of several chronic diseases and may provide an excellent strategy for managing mental health and related outcomes. Wheel-running (WR) is...

Year Published: 2024Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Grigsby, K., Usmani, Z., Anderson, J. et al. 2024. Development and implementation of a Dependable, Simple, and Cost-effective (DSC), open-source running wheel in High Drinking in the Dark and Heterogeneous Stock/Northport mice. Frontiers in Behavioral Neuroscience 17.

A 3D-printed dummy for training distal phalanx amputation in mice

The development of realistic dummies for training the distal phalanx amputation (DPA) technique in mouse pups is a promising alternative to reduce and replace animals in training for research and teaching. To test this, we obtained micro-CT data from postnatal...

Year Published: 2024Topics: Identification MethodAnimal Type: Mouse, Rodent

Citation: Heuser, M., Gonzalez-Uarquin, F., Nuber, M. et al. 2024. A 3D-printed dummy for training distal phalanx amputation in mice. Animals 14(8), 1253.

IntelliCage: The development and perspectives of a mouse- and user-friendly automated behavioral test system

IntelliCage for mice is a rodent home-cage equipped with four corner structures harboring symmetrical double panels for operant conditioning at each of the two sides, either by reward (access to water) or by aversion (non-painful stimuli: air-puffs, LED lights). Corner...

Year Published: 2024Topics: HousingAnimal Type: Mouse, Rodent

Citation: Lipp, H.-P., Krackow, S., Turkes, E. et al. 2024. IntelliCage: The development and perspectives of a mouse- and user-friendly automated behavioral test system. Frontiers in Behavioral Neuroscience 17.