Regulations & Ethical Review

Brexit: A boon or a curse for animals used in scientific procedures?

The UK has long been hailed as one of the world leaders in animal welfare. Within the UK, animals used in experiments are provided some protection under the Animals (Scientific Procedures) Act 1986 (ASPA). This Act was impacted by European...

Year Published: 2021Topics: Regulations & Ethical ReviewAnimal Type: All/General

Citation: Dunn, R. 2021. Brexit: A boon or a curse for animals used in scientific procedures? Animals 11(6), 1547.

Developing recommendations for cumulative endpoints and lifetime use for research animals

Research animals are important for scientific advancement, and therefore, their long-term welfare needs to be monitored to not only minimize suffering, but to provide positive affective states and experiences. Currently, there is limited guidance in countries around the world on...

Year Published: 2021Topics: Humane Endpoint, Regulations & Ethical ReviewAnimal Type: All/General

Citation: Nunamaker, E. A., Davis, S., O'Malley, C. I. et al. 2021. Developing recommendations for cumulative endpoints and lifetime use for research animals. Animals 11(7), 2031.

Breeding and maintenance of immunodeficient mouse lines under SPF conditions—A call for individualized severity analyses and approval procedures

In the EU, the breeding of genetically modified laboratory animals is, by definition, an animal experiment if the offspring may experience pain, suffering, or harm. In order to determine the actual burden of genetically modified mice, established methods are available....

Year Published: 2021Topics: Regulations & Ethical ReviewAnimal Type: Mouse, Rodent

Citation: Kammertoens, T., Jeuthe, S., Baranzke, H. et al. 2021. Breeding and maintenance of immunodeficient mouse lines under SPF conditions—A call for individualized severity analyses and approval procedures. Animals 11(6), 1789.

Reviewing the review: A pilot study of the ethical review process of animal research in Sweden

The use of animals in research entails a range of societal and ethical issues, and there is widespread consensus that animals are to be kept safe from unnecessary suffering. Therefore, harm done to animals in the name of research has...

Year Published: 2021Topics: Regulations & Ethical ReviewAnimal Type: All/General

Citation: Jörgensen, S., Lindsjö, J., Weber, E. M. et al. 2021. Reviewing the review: A pilot study of the ethical review process of animal research in Sweden. Animals 11(3), 708.

Legal frameworks and controls for the protection of research animals: A focus on the animal welfare body with a French case study

In recent years, efforts have been devoted to improving the welfare of laboratory animals. Scientific progress and growing concerns over animal harm have pushed institutions to strengthen their laws to make science more humane and responsible. European Directive 2010/63/EU makes...

Year Published: 2021Topics: Regulations & Ethical ReviewAnimal Type: All/General

Citation: Codecasa, E., Pageat, P., Marcet-Rius, M. et al. 2021. Legal frameworks and controls for the protection of research animals: A focus on the animal welfare body with a French case study. Animals 11(3), 695.

Estimating mouse and rat use in American laboratories by extrapolation from Animal Welfare Act-regulated species

Alone among Western nations, the United States has a two-tier system for welfare protections for vertebrate animals in research. Because its Animal Welfare Act (AWA) excludes laboratory rats and mice (RM), government veterinarians do not inspect RM laboratories and RM...

Year Published: 2021Topics: Regulations & Ethical ReviewAnimal Type: Mouse, Rat, Rodent

Citation: Carbone, L. 2021. Estimating mouse and rat use in American laboratories by extrapolation from Animal Welfare Act-regulated species. Scientific Reports 11(1), 493.

A code of welfare for horses and donkeys: establishing standards for the welfare of equids in New Zealand

New Zealand's code of welfare for horses and donkeys was developed by the National Animal Welfare Advisory Committee (NAWAC), under provisions in the Animal Welfare Act 1999, and issued by the Minister for Primary Industries in 2016. This code applies...

Year Published: 2019Topics: Regulations & Ethical ReviewAnimal Type: Equine

Citation: Cross, N. 2019. A code of welfare for horses and donkeys: establishing standards for the welfare of equids in New Zealand. Journal of Veterinary Behavior 29, 148-149. (13th International Society of Equitation Science (ISES) Conference Abstract)

Guide to the Care and Use of Laboratory Animals, 8th Edition

A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The...

Year Published: 2011Topics: Regulations & Ethical ReviewAnimal Type: All/General

Citation: National Research Council. 2011. Guide to the Care and Use of Laboratory Animals, 8th Edition. The National Academies Press: Washington, DC, 246 pp.

Principles and guidelines for the care and use of non-human primates for scientific purposes

The Principles and guidelines for the care and use of non-human primates for scientific purposes is a revision of NHMRC's Policy on the care and use of non-human primates for scientific purposes 2003 (the Policy). The major differences between the...

Year Published: 2016Topics: Regulations & Ethical ReviewAnimal Type: Baboon, Capuchin, Chimpanzee, Lemur, Macaque, Marmoset, Nonhuman Primate, Other Nonhuman Primate, Owl Monkey, Squirrel Monkey, Vervet (African Green Monkey)

Citation: National Health and Medical Research Council [NHMRC]. 2016. Principles and guidelines for the care and use of non-human primates for scientific purposes. National Health and Medical Research Council: Canberra, Australia, 25 pp.

Postapproval monitoring practices at biomedical research facilities

Federal regulations and policies require institutions to establish procedures for ongoing IACUC oversight of approved animal care and use program activities including animal procedures. To fulfill these requirements, research institutions implement postapproval monitoring (PAM) programs designed to assure compliance in...

Year Published: 2019Topics: Regulations & Ethical ReviewAnimal Type: All/General

Citation: Davis, J. N., Greer, W., Banks, R. E. et al. 2019. Postapproval monitoring practices at biomedical research facilities. JAALAS 58(4), 469-474.