Handling

Effects of repetitive gentle handling of male C57BL/6NCrl mice on comparative behavioural test results

Mice are the most commonly used laboratory animals for studying diseases, behaviour, and pharmacology. Behavioural experiment battery aids in evaluating abnormal behaviour in mice. During behavioural experiments, mice frequently experience human contact. However, the effects of repeated handling on mice...

Year Published: 2020Topics: HandlingAnimal Type: Mouse, Rodent

Citation: Ueno, H., Takahashi, Y., Suemitsu, S. et al. 2020. Effects of repetitive gentle handling of male C57BL/6NCrl mice on comparative behavioural test results. Scientific Reports 10(1), 3509.

Identifying obstacles preventing the uptake of tunnel handling methods for laboratory mice: An international thematic survey

Handling of laboratory mice is essential for experiments and husbandry, but handling can increase anxiety in mice, compromising their welfare and potentially reducing replicability between studies. The use of non-aversive handling (e.g., tunnel handling or cupping), rather than the standard...

Year Published: 2020Topics: HandlingAnimal Type: Mouse, Rodent

Citation: Henderson, L. J., Smulders, T. V., Roughan, J. V. 2020. Identifying obstacles preventing the uptake of tunnel handling methods for laboratory mice: An international thematic survey. PLOS ONE 15(4), e0231454.

Getting a grip: Cats respond negatively to scruffing and clips

Use of scruffing and scruffing tools (eg, clipnosis clips) to immobilise cats is contentious, and cat handling guidelines vary in recommendations regarding these techniques. The current study examined whether cats show negative responses to the following restraint methods: (1) scruff...

Year Published: 2020Topics: Handling, RestraintAnimal Type: Cat

Citation: Moody, C. M., Mason, G. J., Dewey, C. E. et al. 2020. Getting a grip: Cats respond negatively to scruffing and clips. Veterinary Record 186(12), 385.

Now hear this: Caring for chinchillas in research

This article describes the authors’ experience with the housing, social housing, husbandry, handling, and environmental enrichment of chinchillas in laboratories.

Year Published: 2020Topics: Environmental Enrichment, Handling, Housing, Husbandry & ManagementAnimal Type: Chinchilla

Citation: LaFleur, R. A., Williams-Fritze, M. J. 2020. Now hear this: Caring for chinchillas in research. Laboratory Animal Science Professional 8(5) (September/October), 8-12.

Managed care of naked mole-rats

Naked mole-rats are a burgeoning model species in the field of biomedical research and are also housed at many zoos throughout the world. These mammals possess many traits that have a large impact on the way that they are kept...

Year Published: 2021Topics: Biological Sampling & Physiological Measurement, Environmental Enrichment, Handling, Housing, Husbandry & Management, Identification Method, Rearing & Weaning, Relocation & Transport, Reproduction, Restraint, Social Housing & CompanionshipAnimal Type: Mole Rat, Rodent

Citation: Smith, M., Buffenstein, R. 2021. Managed care of naked mole-rats. In: R. Buffenstein, T. J. Park, M. M. Holmes (Eds.), The Extraordinary Biology of the Naked Mole-Rat. Springer International Publishing, pp. 381–407.

Non-aversive handling in laboratory animals and its effects on depressive-like and anxiety-related behaviors: A scoping review

Stress is an adaptive response to environmental demands, but increased intensity and frequency can lead to impaired adaptive functions. Stress is considered a risk factor for Major Depressive Disorder, a multifactorial disorder that often coexists with anxiety. Picking up laboratory...

Year Published: 2025Topics: HandlingAnimal Type: Mouse, Rodent

Citation: Castro de Jesus, L., S․ Rodrigues, A. L. 2025. Non-aversive handling in laboratory animals and its effects on depressive-like and anxiety-related behaviors: A scoping review. Physiology & Behavior 294, 114883.

Alternative handling techniques to reduce anxiety in laboratory mice

The most common and widely used method to capture and transfer mice from cage to cage is to pick up and restrain the mouse by its tail. Recent studies at Liverpool University, however, have indicated that handling mice by their...

Year Published: 2020Topics: Handling, Human-Animal InteractionAnimal Type: Mouse, Rodent

Citation: Thorpe, E. 2020. Alternative handling techniques to reduce anxiety in laboratory mice. Animal Technology and Welfare 19(1), 76–78.

From Fish to Mice to Monkeys in Research: Challenges and Opportunities for Mental Well-being

This chapter focuses mainly on animals in medical research. Many, especially the smaller species such as rat, mice, and zebrafish, may be seen only a few minutes a day by their human caregivers. Most laboratory animals are kept in confinement...

Year Published: 2025Topics: Abnormal/Problematic Behavior, Emotion, Pain, & Sentience, Environmental Enrichment, Handling, Housing, Human-Animal Interaction, Husbandry & Management, Natural Behavior, Regulations & Ethical Review, Social Housing & CompanionshipAnimal Type: All/General, Fish, Macaque, Marmoset, Mouse, Nonhuman Primate, Rat, Rodent, Zebrafish

Citation: Serageldine, C. E., Robinson-Junker, A., Alvino, G. et al. 2025. From Fish to Mice to Monkeys in Research: Challenges and Opportunities for Mental Well-being. In Mental Health and Well-being in Animals (pp. 308–322).

Managed care of naked mole-rats

Year Published: 2021Topics: Environmental Enrichment, Handling, Housing, Husbandry & Management, Identification Method, Natural Behavior, Rearing & Weaning, Relocation & Transport, Reproduction, RestraintAnimal Type: Mole Rat, Rodent

Citation: Smith, M., Buffenstein, R. 2021. Managed care of naked mole-rats. In: R. Buffenstein, T. J. Park, & M. M. Holmes (Eds.), The Extraordinary Biology of the Naked Mole-Rat (pp. 381–407). Springer International Publishing.

Behavioral Biology of Laboratory Animals

This 30-chapter volume informs students and professionals about the behavioral biology of animals commonly housed in laboratory and other captive settings. Each species evolved under specific environmental conditions, resulting in unique behavioral patterns, many of which are maintained in captivity...

Year Published: 2022Topics: Abnormal/Problematic Behavior, Animal Training, Environmental Enrichment, Handling, Housing, Human-Animal Interaction, Husbandry & Management, Natural Behavior, Rearing & Weaning, Social Housing & Companionship, Welfare AssessmentAnimal Type: All/General, Amphibian, Baboon, Capuchin, Cat, Cattle, Chicken, Crocodile & Alligator, Dog, Equine, Ferret, Finch, Fish, Fowl, Frog & Toad, Gerbil, Guinea Pig, Hamster, Lizard, Macaque, Marmoset, Mouse, Nonhuman Primate, Other Rodent, Owl Monkey, Pig, Rabbit, Rat, Reptile, Rodent, Salamander, Sheep, Snake, Squirrel Monkey, Turtle & Tortoise, Vervet (African Green Monkey), Zebrafish

Citation: Coleman, K., Schapiro, S. J. (Eds.) 2022. Behavioral Biology of Laboratory Animals (1st Ed.). CRC Press, Boca Raton, FL, 560 p.