External Bodily Equipment

The effects of housing conditions on baseline cardiovascular parameters and the sensitivity to detect changes in contractility in telemetry-implanted dogs

Introduction: There is a growing weight of evidence to suggest that myocardial contractility is an important parameter to assess as part of IND enabling studies in addition to standard assessments as per the ICH S7A and S7B guidelines. Historically, assessments...

Year Published: 2016Topics: Biological Sampling & Physiological Measurement, External Bodily Equipment, Social Housing & CompanionshipAnimal Type: Dog

Citation: Sadekova, N., Boudreau, G., Jalbert, B. et al. 2016. The effects of housing conditions on baseline cardiovascular parameters and the sensitivity to detect changes in contractility in telemetry-implanted dogs. Journal of Pharmacological and Toxicological Methods 81, 60-74.

Refining housing, husbandry and care for animals used in studies involving biotelemetry

Biotelemetry can contribute towards reducing animal numbers and suffering in disciplines including physiology, pharmacology and behavioural research. However, the technique can also cause harm to animals, making biotelemetry a ‘refinement that needs refining'. Current welfare issues relating to the housing...

Year Published: 2014Topics: External Bodily EquipmentAnimal Type: All/General, Amphibian, Baboon, Bird, Capuchin, Cat, Cattle, Cephalopod, Chicken, Chimpanzee, Chinchilla, Crocodile & Alligator, Crustacean, Dog, Equine, Ferret, Finch, Fish, Fowl, Frog & Toad, Gerbil, Gibbon, Goat, Guinea Pig, Hamster, Insect & Spider, Invertebrate, Lemur, Lizard, Macaque, Marine Mammal, Marmoset, Mink, Mole Rat, Mouse, Nonhuman Primate, Other Animal, Other Bird, Other Fish, Other Invertebrate, Other Nonhuman Primate, Other Rodent, Owl Monkey, Parrot, Pig, Rabbit, Rat, Reptile, Rodent, Salamander, Salmon, Shark & Ray, Sheep, Snake, Squirrel Monkey, Tilapia, Trout, Turtle & Tortoise, Vervet (African Green Monkey), Zebrafish

Citation: Hawkins, P. 2014. Refining housing, husbandry and care for animals used in studies involving biotelemetry. Animals 4(2), 361-373.

Strategies to encourage the adoption of social housing during cardiovascular telemetry recordings in non-rodents

The National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) is working with industry to promote social housing during cardiovascular telemetry recordings within non-rodent safety pharmacology and toxicology studies. Following surveys to capture current practice, benefits...

Year Published: 2021Topics: Biological Sampling & Physiological Measurement, External Bodily Equipment, Social Housing & CompanionshipAnimal Type: Dog, Macaque, Nonhuman Primate, Pig

Citation: Prior, H., Holbrook, M. 2021. Strategies to encourage the adoption of social housing during cardiovascular telemetry recordings in non-rodents. Journal of Pharmacological and Toxicological Methods 108, 106959.

Social housing of non-rodents during cardiovascular recordings in safety pharmacology and toxicology studies

Introduction: The Safety Pharmacology Society (SPS) and National Centre for the Replacement, Refinement & Reduction of Animals in Research (NC3Rs) conducted a survey and workshop in 2015 to define current industry practices relating to housing of non-rodents during telemetry recordings...

Year Published: 2016Topics: Biological Sampling & Physiological Measurement, External Bodily Equipment, Social Housing & CompanionshipAnimal Type: Dog, Macaque, Nonhuman Primate, Pig

Citation: Prior, H., Bottomly, A., Champéroux, P. et al. 2016. Social housing of non-rodents during cardiovascular recordings in safety pharmacology and toxicology studies. Journal of Pharmacological and Toxicological Methods 81, 75-87.

Assessment of a noninvasive chronic glucose monitoring system in euglycemic and diabetic swine (Sus scrofa)

Models of type-I diabetes are well-characterized and commonly used in the preclinical evaluation of drugs and medical devices. The diabetic minipig is an excellent example of a translational model. However, chronic glucose monitoring in this species can be challenging; frequent...

Year Published: 2020Topics: Biological Sampling & Physiological Measurement, Disease/Experimental Model, External Bodily EquipmentAnimal Type: Pig

Citation: Ober, R. A., Geist, G. E. 2020. Assessment of a noninvasive chronic glucose monitoring system in euglycemic and diabetic swine (Sus scrofa). JAALAS 59(4), 430-437.

Assessing the safety and suitability of nesting material for singly housed mice with surgically fitted head plates

Nesting material, for example shredded paper, is a common form of enrichment for laboratory mice. However, there has been limited research performed regarding its apparent safety when given to mice fitted with exteriorised devices such as head plates. Anecdotally, shredded...

Year Published: 2019Topics: Environmental Enrichment, External Bodily EquipmentAnimal Type: Mouse, Rodent

Citation: Windsor, Z., Bate, S. T. 2019. Assessing the safety and suitability of nesting material for singly housed mice with surgically fitted head plates. Heliyon 5(7), e02097.

A systematic review of the potential uses of on-animal sensors to monitor the welfare of sheep evaluated using the Five Domains Model as a framework

This systematic review explores the use of on-animal sensors in sheep and their potential application in objective welfare monitoring. The key questions posed were: To what extent can current scientific knowledge inform a sensor-based approach to welfare evaluations? And, how...

Year Published: 2019Topics: External Bodily Equipment, Welfare AssessmentAnimal Type: Sheep

Citation: Fogarty, E. S., Swain, D. L., Cronin, G. M. et al. 2019. A systematic review of the potential uses of on-animal sensors to monitor the welfare of sheep evaluated using the Five Domains Model as a framework. Animal Welfare 28(4), 407-420.

Behavioural and physiological responses of laying hens to automated monitoring equipment

Automated monitoring of behaviour can offer a wealth of information in circumstances where observing behaviour is difficult or time consuming. However, this often requires attaching monitoring devices to the animal which can alter behaviour, potentially invalidating any data collected. Birds...

Year Published: 2018Topics: External Bodily EquipmentAnimal Type: Bird, Chicken

Citation: Buijs, S., Booth, F., Richards, G. et al. 2018. Behavioural and physiological responses of laying hens to automated monitoring equipment. Applied Animal Behaviour Science 199, 17-23.

Improving safety assessment studies by the introduction of a refined ECG vest for dogs

This study describes a refined/modified vest and jacket worn by dogs to capture ECG data after they are given a compound of interest. The modified vest and jacket prevents dogs from chewing the leads and avoiding the need to repeat...

Year Published: 2018Topics: External Bodily EquipmentAnimal Type: Dog

Citation: Fisher, P. 2018. Improving safety assessment studies by the introduction of a refined ECG vest for dogs. Animal Technology and Welfare 17(1), 48-49.

Report of a RSPCA/APHA meeting on the welfare of wild animals used in research

This is a report of a one-day meeting jointly convened by the RSPCA and the Animal and Plant Health Agency (APHA), which brought together around 70 researchers, veterinarians, animal technologists, regulators and others with an interest in the welfare of...

Year Published: 2017Topics: Abnormal/Problematic Behavior, External Bodily Equipment, Husbandry & Management, Welfare AssessmentAnimal Type: All/General

Citation: Reed, B., Beatham, S., Carter, S. et al. 2017. Report of a RSPCA/APHA meeting on the welfare of wild animals used in research. Animal Technology and Welfare 16(1), 13-25. [Meeting Report]