Drug/Substance Administration

Are “”by-stander”” female Sprague-Dawley rats affected by experimental procedures? Contemporary Topics in Laboratory Animal Science 42(1), 19-28

The objective of this study was to test the hypotheses that female rats are stressed by being in the same room as animals subjected to common husbandry and experimental procedures and that the level of stress is affected by housing...

Year Published: 2003Topics: Drug/Substance Administration, Euthanasia, Handling, Husbandry & Management, Restraint, Social Housing & CompanionshipAnimal Type: Rat, Rodent

Citation: Sharp, J. L., Zammit, T., Azar, T. A. et al. 2003. Are "by-stander" female Sprague-Dawley rats affected by experimental procedures? Contemporary Topics in Laboratory Animal Science 42(1), 19-28.

The welfare impact of gavaging laboratory rats

A significant correlation between heart rate and dosage was observed until 10 min after gavaging.

Year Published: 2005Topics: Drug/Substance AdministrationAnimal Type: Rat, Rodent

Citation: Bonnichsen, M., Dragsted, N., Hansen, A. K. 2005. The welfare impact of gavaging laboratory rats. Animal Welfare 14, 223-227.

Effect of restraint and injection methods on heart rate and body temperature in mice

It was found that heart rate (HR), and to a lesser extent also body temperature (BT), parallels plasma corticosterone (pCORT) values after subjecting the animals to different methods of restraint. Secondly, the acute stress response caused by different injection methods...

Year Published: 2006Topics: Drug/Substance Administration, RestraintAnimal Type: Mouse, Rodent

Citation: Meijer, M. K., Spruijt, B. M., van Zutphen, L. F. M. et al. 2006. Effect of restraint and injection methods on heart rate and body temperature in mice. Laboratory Animals 40(4), 82-391.

Working with animals: Oral drug administration – how to minimize stress reactions for rabbits, rodents and pigs

With gentle firmness, patience and professional skills most warm-blooded animals - with the exception perhaps of mice - can be habituated to tolerate oral dosing. Rabbits, rats and pigs accept most drugs if these are mixed in specially flavored and...

Year Published: 2007Topics: Drug/Substance AdministrationAnimal Type: Pig, Rabbit, Rodent

Citation: LAREF [Laboratory Animal Refinement and Enrichment Forum] 2007. Working with animals: Oral drug administration - how to minimize stress reactions for rabbits, rodents and pigs. In: Making Lives Easier for Animals in Research Labs: Discussions by the Laboratory Animal Refinement & Enrichment Forum. Baumans, V., Coke, C., Green, J., Moreau, E., Morton, D., Patterson-Kane, E., Reinhardt, A., Reinhardt, V., Van Loo, P. (eds), 124-126. Animal Welfare Institute, Washington, DC.

Investigation of a novel refined oral dosing method

Over six days, male Lister Hooded rats wre trained to drink from a syringe containing either a 5-10% surose solution or 1mg/ml donepezil suspended in 5-10% sucrose solution. After just a few days training, there were significant reductions in the...

Year Published: 2007Topics: Drug/Substance AdministrationAnimal Type: Rat, Rodent

Citation: Rourke, C., Pemberton, D. J. 2007. Investigation of a novel refined oral dosing method. Institute of Animal Technology [IAT] Congress, 46 (Abstract).

Chapter 7.3. Oral Drug Administration? How to minimize Stress Reactions

Our vervet monkeys voluntarily swallow drugs when we mix these with their regular diet, consisting on pre-cooked maize, fortified with vitamins, minerals and other ingredients. The dry ingredients are blended with water and form a stiff putty-like paste, which is...

Year Published: 2007Topics: Drug/Substance AdministrationAnimal Type: Nonhuman Primate, Vervet (African Green Monkey)

Citation: LAREF [Laboratory Animal Refinement and Enrichment Forum] 2007. Chapter 7.3. Oral Drug Administration?How to minimize Stress Reactions. In: Making Lives Easier for Animals in Research Labs: Discussions by the Laboratory Animal Refinement & Enrichment Forum. Baumans, V., Coke, C., Green, J., Moreau, E., Morton, D., Patterson-Kane, E., Reinhardt, A., Reinhardt, V., Van Loo, P. (eds), 126-127. Animal Welfare Institute, Washington, DC.

Playful handling mitigates the stressfulness of injections in laboratory rats

Rats can be playfully handled (tickled) in a manner that mimics playful social contact with conspecifics. We hypothesized that the timing of tickling in relation to an intraperitoneal injection would affect the efficacy of tickling in reducing stress associated with...

Year Published: 2010Topics: Drug/Substance Administration, HandlingAnimal Type: Rat, Rodent

Citation: Cloutier, S., Wahl, K., Newberry, R. C. 2010. Playful handling mitigates the stressfulness of injections in laboratory rats. American Association for Laboratory Animal Science [AALAS] Meeting Official Program, 721 (Abstract #P126).

A technique for single-person oral gavage in rabbits

The physiologic and anatomic structure of rabbits can cause high mortality rates in rabbit oral gavage. Rabbits are capable of a wide variety of jaw movement due to 3 jaw-closing muscle groups (masseter, temporalis, pterygoid). This complex and intricate architecture...

Year Published: 2010Topics: Drug/Substance AdministrationAnimal Type: Rabbit

Citation: Van Dyk, A., Rickers, M. 2010. A technique for single-person oral gavage in rabbits. American Association for Laboratory Animal Science [AALAS] Meeting Official Program, 749 (Abstract #P215).

Report of the 2010 RSPCA/UFAW rodent welfare group meeting – The effect of husbandry on welfare and promoting good practice

The RSPCA/UFAW Rodent Welfare Group holds a one-day meeting every autumn so that its members can discuss current welfare research, exchange views on rodent welfare issues and share experiences of the implementation of the 3Rs of replacement, reduction and refinement...

Year Published: 2011Topics: Drug/Substance Administration, Handling, Husbandry & Management, Welfare AssessmentAnimal Type: Mouse, Rabbit, Rat, Rodent

Citation: Hawkins, P., Burn, C., Hurst, J. et al. 2011. Report of the 2010 RSPCA/UFAW rodent welfare group meeting - The effect of husbandry on welfare and promoting good practice. Animal Technology and Welfare 10(2), 105-114.

Using olive oil to orally dose laboratory rats

Many compounds are orally administered to laboratory rats using the gavage technique. This technique is stressful for the animal and can cause injury or death if performed incorrectly. Often compounds are suspended in food oils such as corn oil for...

Year Published: 2011Topics: Drug/Substance AdministrationAnimal Type: Rat, Rodent

Citation: Fitchett, A., Judge, S., Morris, C. 2011. Using olive oil to orally dose laboratory rats. Animal Technology and Welfare 10(1), 39-41.