Drug/Substance Administration

Maintenance of the Brugia Malayi life cycle in Mongolian gerbils

The Mongolian gerbil or jird (Meriones unguiculatus) is a rodent belonging to the subfamily Gerbillinae. They are commonly used as models for a variety of infectious diseases such as Hepatitis E virus and Giardia lamblia. At the LSTM/University of Liverpool...

Year Published: 2025Topics: Cannulation, Catheterization, & Intubation, Disease/Experimental Model, Drug/Substance AdministrationAnimal Type: Gerbil, Rodent

Citation: Steven, A. 2025. Maintenance of the Brugia Malayi life cycle in Mongolian gerbils. Animal Technology and Welfare 24(2), 155–156.

A sweet change to the needle

Our Named Veterinary Surgeon (NVS) suggested providing post-operative pain relief in flavoured jelly to avoid the use of needles. We made up batches of non-medicated jelly to try them with first. We provided this nonmedicated jelly for three days before...

Year Published: 2020Topics: Drug/Substance AdministrationAnimal Type: Rat, Rodent

Citation: Forrest, G., Sattar, A. et al. 2020. A sweet change to the needle. Animal Technology and Welfare 19(1), 73–75.

Mouse strain-specific habituation to oral metamizole administration

When pain might occur during an animal experiment, sufficient analgesia is necessary. Metamizole is the third most used postoperative pain medication in animal research. The analgesic effect of metamizole is supposed to last 6–8 h in rodents. Therefore, the supplementation of...

Year Published: 2025Topics: Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Schreiber, T., Leitner, E., Brandstetter, J. et al. 2025. Mouse strain-specific habituation to oral metamizole administration. Laboratory Animals 59(2), 192–202.

Preceding sevoflurane inhalation in rats reduces the stress of intraperitoneal injection both in inexperienced experimenters and subject rats

In this study, we found that sevoflurane inhalation in rats prior to intraperitoneal injection decreased stress in both inexperienced experimenters and subject rats. Inexperienced experimenters anaesthetised male Sprague Dawley rats by intraperitoneal injection of anaesthetics, with or without preceding sevoflurane...

Year Published: 2025Topics: Drug/Substance AdministrationAnimal Type: Rat, Rodent

Citation: Ishibashi, H., Motohashi, H. 2025. Preceding sevoflurane inhalation in rats reduces the stress of intraperitoneal injection both in inexperienced experimenters and subject rats. Laboratory Animals 59(2), 272–275.

Pharmacokinetics and effectiveness of precise voluntary consumption compared to subcutaneous administration of cephalosporins in rats following orthopedic surgery

The administration of antibiotics is a critical variable when developing animal models of infection. Handling and needle use, however, can cause distress in the animals, leading not only to irritability of the animal but potentially skewed inflammatory data in studies...

Year Published: 2025Topics: Drug/Substance AdministrationAnimal Type: Rat, Rodent

Citation: Shiels, S. M., Sandoval, C. M., Riddle, L. E. et al. 2025. Pharmacokinetics and effectiveness of precise voluntary consumption compared to subcutaneous administration of cephalosporins in rats following orthopedic surgery. Journal of the American Association for Laboratory Animal Science 64(3), 385–392.

Gavage-needle voluntary consumption administration of a dose-specific measure to mice (Mus musculus)

Orogastric gavage is a common technique used to administer test articles to rodents with risks ranging from increased stress to death of the animal. In this study, we propose a novel technique to administer treatments to mice for voluntary consumption...

Year Published: 2025Topics: Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Punger, E. M., Norris, S. L., Stevens, S. C. et al. 2025. Gavage-needle voluntary consumption administration of a dose-specific measure to mice (Mus musculus). Journal of the American Association for Laboratory Animal Science 64(2), 287–293.

A single-dose pharmacokinetic study of metronidazole administered to Gottingen minipigs (Sus scrofa) by oral gavage or voluntary oral dosing

Oral gavage (OG) dosing can be stressful to pigs and is associated with the risk of complications. To evaluate a potential refinement, we compared the pharmacokinetics of a drug with a known aversive taste (metronidazole) administered orally to 6 Gottingen...

Year Published: 2025Topics: Animal Training, Drug/Substance AdministrationAnimal Type: Pig

Citation: Cooper, D. M., Rainey, A., Rosenfeld, C. et al. 2025. A single-dose pharmacokinetic study of metronidazole administered to Gottingen minipigs (Sus scrofa) by oral gavage or voluntary oral dosing. Journal of the American Association for Laboratory Animal Science 64(3), 514–519.

Advances in technical methods and applications of subretinal injections in experimental animals (2025)

The subretinal injection technique is an important intraocular drug delivery modality that allows access to the subretinal space to directly act on target cells or the administration of medications, markedly improving the therapeutic efficacy of ocular diseases. Subretinal injection in...

Year Published: 2025Topics: Drug/Substance AdministrationAnimal Type: All/General

Citation: Song, C., Ji, Y., Wang, Y. et al. 2025. Advances in technical methods and applications of subretinal injections in experimental animals. Frontiers in Veterinary Science 12.

Analgesia administration practices to support minimal handling (2024)

An adequate analgesic strategy is important to improve the postoperative recovery and welfare of laboratoy animals. It is desirable that the method for administering the drug is non-invasive and stress-free. Below are a few methods that we use to minimise...

Year Published: 2024Topics: Analgesia, Drug/Substance Administration, Surgery & Post-OpAnimal Type: Mouse, Rodent

Citation: Keenan, R., Lynch, A., Murphy, S. et al. 2024. Analgesia administration practices to support minimal handling. Animal Technology and Welfare 23(3), 239–240.

Refined method of Tropicamide application in minipigs

The objective of this experiment was to investigate the efficacy of Tropicamide when administered using a new spray method (compared to eye drop method).

Year Published: 2024Topics: Drug/Substance AdministrationAnimal Type: Pig

Citation: Gracey, K. 2024. Refined method of Tropicamide application in minipigs. Animal Technology and Welfare 23(2), 145–147.