Disease/Experimental Model

Diagnostic ability of methods depicting distress of tumor-bearing mice

Subcutaneous tumor models in mice are the most commonly used experimental animal models in cancer research. To improve animal welfare and the quality of scientific studies, the distress of experimental animals needs to be minimized. For this purpose, one must...

Year Published: 2021Topics: Disease/Experimental Model, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Xie, W., Kordt, M., Palme, R. et al. 2021. Diagnostic ability of methods depicting distress of tumor-bearing mice. Animals 11(8), 2155.

A novel model of ischemia in rats with middle cerebral artery occlusion using a microcatheter and zirconia ball under fluoroscopy

Here, we present a highly selective rat MCAO model by percutaneous caudal arterial puncture using a microcatheter and zirconia ball under fluoroscopic guidance. The model is predictable and reproducible, which is well confined within the territory supplied by the MCA,...

Year Published: 2021Topics: Disease/Experimental ModelAnimal Type: Rat, Rodent

Citation: Komatsu, T., Ohta, H., Motegi, H. et al. 2021. A novel model of ischemia in rats with middle cerebral artery occlusion using a microcatheter and zirconia ball under fluoroscopy. Scientific Reports 11(1), 12806.

Environmental enrichment and mouse models: Current perspectives

The provision of environmental enrichment to numerous species of laboratory animals is generally considered routine husbandry. However, mouse enrichment has proven to be very complex due to the often contradictory outcomes (animal health and welfare, variability in scientific data, etc.)...

Year Published: 2018Topics: Disease/Experimental Model, Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Bayne, K. 2018. Environmental enrichment and mouse models: Current perspectives. Animal Models and Experimental Medicine 1(2), 82-90.

Comparison of the effects of osmotic pump implantation with subcutaneous injection for administration of drugs after total body irradiation in mice

The increasing potential for radiation exposure from nuclear accidents or terrorist activities has intensified the need to develop pharmacologic countermeasures against injury from total body irradiation (TBI). Many initial experiments to develop and test these countermeasures utilize murine irradiation models....

Year Published: 2021Topics: Cannulation, Catheterization, & Intubation, Disease/Experimental Model, Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Koch, A. L., Rusnak, M., Peachee, K. et al. 2021. Comparison of the effects of osmotic pump implantation with subcutaneous injection for administration of drugs after total body irradiation in mice. Laboratory Animals 55(2), 142-149.

Reducing suffering in animal models and procedures involving seizures, convulsions and epilepsy

This report is based on discussions and submissions from an expert working group consisting of veterinarians, animal care staff and scientists with expert knowledge relevant to the field and aims to facilitate the implementation of the Three Rs (replacement, reduction...

Year Published: 2013Topics: Disease/Experimental ModelAnimal Type: Mouse, Rat, Rodent

Citation: Wolfensohn, S., Hawkins, P., Lilley, E. et al. 2013. Reducing suffering in animal models and procedures involving seizures, convulsions and epilepsy. Journal of Pharmacological and Toxicological Methods 67(1), 9-15.

Effects of analgesics on tumor growth in mouse models of prostate cancer bone metastasis

Murine models of tumor development often require invasive procedures for tumor implantation, potentially causing pain or distress. However, analgesics are often withheld during implantation because of concerns that they may adversely affect tumor development. Previous studies examining the effects of...

Year Published: 2021Topics: Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Xu, J. J., Thurston, S. E., Robinson, T. J. et al. 2021. Effects of analgesics on tumor growth in mouse models of prostate cancer bone metastasis. JAALAS 60(3), 341-348.

Reducing suffering in experimental autoimmune encephalomyelitis (EAE)

This report is based on discussions and submissions from an expert working group consisting of veterinarians, animal care staff and scientists with expert knowledge relevant to the field. It aims to facilitate the implementation of the Three Rs (replacement, reduction...

Year Published: 2013Topics: Disease/Experimental ModelAnimal Type: Dog, Guinea Pig, Hamster, Macaque, Marmoset, Mouse, Nonhuman Primate, Rabbit, Rat, Rodent, Sheep

Citation: Wolfensohn, S., Hawkins, P., Lilley, E. et al. 2013. Reducing suffering in experimental autoimmune encephalomyelitis (EAE). Journal of Pharmacological and Toxicological Methods 67(3), 169-176.

The development of a non-invasive behavioral model of thermal heat stress in laboratory mice (Mus musculus)

Background: Many behavioral and physiological studies of laboratory mice employ invasive methods such as radio telemetry to measure key aspects of behavior and physiology. Radio telemetry requires surgical implants, which may impact mouse health and behavior, and thus reduce the...

Year Published: 2016Topics: Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Mufford, J. T., Paetkau, M.J., Flood, N.J. et al. 2016. The development of a non-invasive behavioral model of thermal heat stress in laboratory mice (Mus musculus). Journal of Neuroscience Methods 268, 189-195.

Applying refinement to the use of mice and rats in rheumatoid arthritis research

Rheumatoid arthritis (RA) is a painful, chronic disorder and there is currently an unmet need for effective therapies that will benefit a wide range of patients. The research and development process for therapies and treatments currently involves in vivo studies,...

Year Published: 2015Topics: Disease/Experimental ModelAnimal Type: Mouse, Rat, Rodent

Citation: Hawkins, P., Armstrong, R., Boden, T. et al. 2015. Applying refinement to the use of mice and rats in rheumatoid arthritis research. Inflammopharmacology 23, 131–150.

Strategies to improve survival from surgery for heart valve implantation in sheep

Sheep are a commonly used and validated model for cardiovascular research and, more specifically, for heart valve research. Implanting a heart valve on the arrested heart in sheep is complex and is often complicated by difficulties in restarting the heart,...

Year Published: 2021Topics: Disease/Experimental Model, Surgery & Post-OpAnimal Type: Sheep

Citation: Vis, A., Lammers, J. C. A. M., de Vroege, R. et al. 2021. Strategies to improve survival from surgery for heart valve implantation in sheep. Comparative Medicine 71(3), 235-239.