Biological Sampling & Physiological Measurement

A new group housing approach for non-human primate metabolism studies

Understanding the absorption, distribution, metabolism and excretion (ADME) of candidate drugs in preclinical species is an integral part of the safety and efficacy evaluation in drug development. For this purpose, the housing of single animals in metabolism cages has historically...

Year Published: 2021Topics: Biological Sampling & Physiological Measurement, Social Housing & CompanionshipAnimal Type: Macaque, Nonhuman Primate

Citation: Stow, R., Kendrick, J., Ibbotson, N. et al. 2021. A new group housing approach for non-human primate metabolism studies. Journal of Pharmacological and Toxicological Methods 107, 106947.

The effects of housing conditions on baseline cardiovascular parameters and the sensitivity to detect changes in contractility in telemetry-implanted dogs

Introduction: There is a growing weight of evidence to suggest that myocardial contractility is an important parameter to assess as part of IND enabling studies in addition to standard assessments as per the ICH S7A and S7B guidelines. Historically, assessments...

Year Published: 2016Topics: Biological Sampling & Physiological Measurement, External Bodily Equipment, Social Housing & CompanionshipAnimal Type: Dog

Citation: Sadekova, N., Boudreau, G., Jalbert, B. et al. 2016. The effects of housing conditions on baseline cardiovascular parameters and the sensitivity to detect changes in contractility in telemetry-implanted dogs. Journal of Pharmacological and Toxicological Methods 81, 60-74.

Comparison of sublingual, facial and retro-bulbar blood sampling in mice in relation to animal welfare and blood quality

Introduction: Repeated blood sampling is a common procedure in laboratory mice, but at present it is unknown which technique has the least impact on the animals when large or repeated blood samples are required. Retro-bulbar sinus puncture is a reliable...

Year Published: 2020Topics: Biological Sampling & Physiological MeasurementAnimal Type: Mouse, Rodent

Citation: Gjendal, K., Kiersgaard, M. K., Abelson, K. et al. 2020. Comparison of sublingual, facial and retro-bulbar blood sampling in mice in relation to animal welfare and blood quality. Journal of Pharmacological and Toxicological Methods 103, 106680.

Social-housing and use of double-decker cages in rat telemetry studies

Rat telemetry is widely used for biomedical research purposes and is used routinely in early pre-clinical drug development to screen for the potential cardiovascular risk of candidate drugs. Historically, these studies have been conducted in individually housed conditions which can...

Year Published: 2019Topics: Biological Sampling & Physiological Measurement, External Bodily Equipment, Housing, Social Housing & CompanionshipAnimal Type: Rat, Rodent

Citation: Skinner, M., Ceuppens, P., White, P. et al. 2019. Social-housing and use of double-decker cages in rat telemetry studies. Journal of Pharmacological and Toxicological Methods 96, 87-94.

Welfare of the minipig with special reference to use in regulatory toxicology studies

This paper reviews the animal welfare challenges associated with the use of minipigs in toxicology testing, and compares these to published knowledge on the other widely used non-rodent species (dogs and non-human primates). Welfare challenges arise from housing and management...

Year Published: 2010Topics: Biological Sampling & Physiological MeasurementAnimal Type: Pig

Citation: Ellegaard, L., Cunningham, A., Edwards, S. et al. 2010. Welfare of the minipig with special reference to use in regulatory toxicology studies. Journal of Pharmacological and Toxicological Methods 62(3), 167-183.

Non-invasive monitoring of avian embryo heart rate

Non-invasive monitoring of the heart rate allows measuring the condition of the chick embryo in the incubation process without negative consequences for the future chick. The optical method for registering heartbeats is available to a wide range of incubation specialists...

Year Published: 2019Topics: Biological Sampling & Physiological MeasurementAnimal Type: Bird, Chicken

Citation: Andrianov, E. A., Sudakov, A. N., Andrianov, A. A. et al. 2019. Non-invasive monitoring of avian embryo heart rate. Journal of Animal Behaviour and Biometeorology 7(3), 119-122.

Using infrared thermography to measure the body surface temperature of crossbred cows and calves in the semi-arid region of Minas Gerais, Brazil

This study aimed to evaluate the body surface temperature of crossbreed cows and calves managed in the semi-arid region of Minas Gerais (Brazil), using the infrared thermography technique. The thermal environment was characterized by daily collections of meteorological variables and...

Year Published: 2019Topics: Biological Sampling & Physiological MeasurementAnimal Type: Cattle

Citation: Carvalho, C. da C. S., Cordeiro de Souza, A., Ferreira, H. C. et al. 2019. Using infrared thermography to measure the body surface temperature of crossbred cows and calves in the semi-arid region of Minas Gerais, Brazil. Journal of Animal Behaviour and Biometeorology 7(3), 132-136.

Infrared thermal image for assessing animal health and welfare

Infrared thermal imaging is a non-destructive testing technology that can be used to determine the superficial temperature of objects. This technology has an increasing use in detecting diseases and distress in animal husbandry within the poultry, pig and dairy production....

Year Published: 2015Topics: Biological Sampling & Physiological Measurement, Welfare AssessmentAnimal Type: Bird, Cattle, Chicken, Pig

Citation: Nääs, I. A., Garcia, R. G., Caldara, F. R. 2015. Infrared thermal image for assessing animal health and welfare. Journal of Animal Behaviour and Biometeorology 2(3), 66-72.

The urinary hormonal state of cats associated with social interaction with humans

Research to assess the relationship between cats and humans is in a nascent stage. Some studies have assessed the stress status in cats using physiological indicators, such as the cortisol hormone, but have not focused on the social interaction with...

Year Published: 2021Topics: Biological Sampling & Physiological Measurement, Human-Animal Interaction, Welfare AssessmentAnimal Type: Cat

Citation: Nagasawa, T., Ohta, M., Uchiyama, H. 2021. The urinary hormonal state of cats associated with social interaction with humans. Frontiers in Veterinary Science 8, 680843.

Environmental salinity modifies mucus exudation and energy use in European sea bass juveniles

Changes in skin mucus production and composition offer a new means to study how fish cope with changes in the environment. We explored the utility of skin mucus as an indicator of physiological responses and energy use in a reference...

Year Published: 2021Topics: Biological Sampling & Physiological MeasurementAnimal Type: Fish, Other Fish

Citation: Ordóñez-Grande, B., Guerreiro, P. M., Sanahuja, I. et al. 2021. Environmental salinity modifies mucus exudation and energy use in European sea bass juveniles. Animals 11(6), 1580.