Anesthesia & Sedation

Repeated anaesthesia with isoflurane and medetomidine-midazolam-fentanyl in guinea pigs and its influence on physiological parameters

Repeated anaesthesia may be required in experimental protocols and in daily veterinary practice, but anaesthesia is known to alter physiological parameters in GPs (Cavia porcellus, GPs). This study investigated the effects of repeated anaesthesia with either medetomidine-midazolam-fentanyl (MMF) or isoflurane...

Year Published: 2017Topics: Anesthesia & SedationAnimal Type: Guinea Pig, Rodent

Citation: Schmitz, S., Tacke, S., Guth, B. et al. 2017. Repeated anaesthesia with isoflurane and medetomidine-midazolam-fentanyl in guinea pigs and its influence on physiological parameters. PLOS ONE 12(3), e0174423.

Severity classification of repeated isoflurane anesthesia in C57BL/6JRj mice—Assessing the degree of distress

According to the EU Directive 2010/63, the severity of a procedure has to be classified as mild, moderate or severe. General anesthesia is thought to be mild, but the Directive does not differentiate between single and repeated anesthesia. Therefore, we...

Year Published: 2017Topics: Anesthesia & SedationAnimal Type: Mouse, Rodent

Citation: Hohlbaum, K., Bert, B., Dietze, S. et al. 2017. Severity classification of repeated isoflurane anesthesia in C57BL/6JRj mice—Assessing the degree of distress. PLOS ONE 12(6), e0179588.

The influence of isoflurane anaesthesia on the rat grimace scale

Over 234,000 rats were used in regulated procedures in the UK in 2014, many of which may have resulted in some degree of pain. When using animals in research, there is an ethical and legal responsibility to alleviate or at...

Year Published: 2016Topics: Anesthesia & Sedation, Welfare AssessmentAnimal Type: Rat, Rodent

Citation: Miller, A. L., Golledge, H. D. R., Leach, M. C. 2016. The influence of isoflurane anaesthesia on the rat grimace scale. PLOS ONE 11(11), e0166652.

Effect of topically applied anaesthetic formulation on the sensitivity of scoop dehorning wounds in calves

The post-operative effects of three formulations of topical anaesthetic and a cornual nerve block on the sensitivity of scoop dehorning wounds in calves were compared in two trials. In Trial 1, 21 female Holstein dairy calves aged 8 to 24...

Year Published: 2016Topics: Anesthesia & Sedation, Body Modification/MutilationAnimal Type: Cattle

Citation: McCarthy, D., Windsor, P. A., Harris, C. et al. 2016. Effect of topically applied anaesthetic formulation on the sensitivity of scoop dehorning wounds in calves. PLOS ONE 11(9), e0163181.

Electrophysiological investigation of different methods of anesthesia in lobster and crayfish

Objectives: In search for methods of anesthesia of crustaceans, an implanted electrode into lobster and crayfish CNS enabled us to monitor signal propagation in the nerve system of animals undergoing different protocols. Results: Cooling (tap water 0°C, sea water -1,8°C)...

Year Published: 2016Topics: Anesthesia & SedationAnimal Type: Crustacean

Citation: Fregin, T., Bickmeyer U. 2016. Electrophysiological investigation of different methods of anesthesia in lobster and crayfish. PLOS ONE 11(9), e0162894.

Comparison of physiological parameters and anaesthesia specific observations during isoflurane, ketamine-xylazine or medetomidine-midazolam-fentanyl anaesthesia in male guinea pigs

Guinea pigs (GPs) are difficult to anaesthetize successfully, the choices for anaesthesia are limited and physiological parameters are likely to be influenced substantially under anaesthesia. We implanted blood pressure radio-telemetry devices into 16 male GPs and subjected them to anaesthesia...

Year Published: 2016Topics: Anesthesia & SedationAnimal Type: Guinea Pig, Rodent

Citation: Schmitz, S., Tacke, S., Guth, B. et al. 2016. Comparison of physiological parameters and anaesthesia specific observations during isoflurane, ketamine-xylazine or medetomidine-midazolam-fentanyl anaesthesia in male guinea pigs. PLOS ONE 11(9), e0161258.

Effect of strain and group size on the response of mice to sconal anaesthesia

The variance of the response to a barbiturate anaesthetic was greater if male mice were caged either singly or in groups of eight than if they were caged in pairs.

Year Published: 1962Topics: Anesthesia & Sedation, Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Mackintosh, J. H. 1962. Effect of strain and group size on the response of mice to sconal anaesthesia. Nature 194, 1304.

Influence of restraint and ketamine anesthesia on adrenal steroids, progesterone, and gonadotropins in rhesus monkeys

Determination of basal circulating hormone levels in nonhuman primates presents a problem since handling or restraint of the animal for venipuncture may introduce sufficient stress to change hormonal secretion. ...Each bleeding was made in conscious [female] monkeys after restraining the...

Year Published: 1984Topics: Anesthesia & Sedation, RestraintAnimal Type: Macaque, Nonhuman Primate

Citation: Fuller, G. B., Hobson, W. C., Reyes, F. I. et al. 1984. Influence of restraint and ketamine anesthesia on adrenal steroids, progesterone, and gonadotropins in rhesus monkeys. Proceedings of the Society for Experimental Biology and Medicine 175, 487-490.

Preparing New World monkeys for laboratory research

New World monkeys represent an important but often poorly understood research resource. The relatively small size and low zoonotic risk of these animals make them appealing as research subjects in a number of areas. However, historic portrayal of many of...

Year Published: 2006Topics: Anesthesia & Sedation, Handling, Husbandry & Management, Relocation & Transport, Restraint, Social Housing & Companionship, Welfare AssessmentAnimal Type: Marmoset, Nonhuman Primate, Other Nonhuman Primate, Owl Monkey, Squirrel Monkey

Citation: Tardif, S. D., Bales, K., Williams, L. et al. 2006. Preparing New World monkeys for laboratory research. ILAR Journal 47(4), 307-315.

Issues to consider for preparing ferrets as research subjects in the laboratory

Successful housing requires knowledge of ferret behaviors including social behavior, eating habits, a general inquisitive nature, and a species-typical need to burrow and hide. Regular handling is necessary to maintain well-being. A ferret health care program consists of physical examination,...

Year Published: 2006Topics: Anesthesia & Sedation, Biological Sampling & Physiological Measurement, Euthanasia, Handling, Husbandry & Management, Natural Behavior, Rearing & Weaning, Relocation & Transport, Reproduction, RestraintAnimal Type: Ferret

Citation: Ball, R. S. 2006. Issues to consider for preparing ferrets as research subjects in the laboratory. ILAR Journal 47(4), 348-357.