Analgesia

Anaesthetics and analgesics used in adult fish for research: A review

The number of fish used in research has increased in the last decades. Anaesthesia is required when fish must be held immobile and it is crucial to promote fish welfare, because these vertebrates can show signs of stress and/or pain...

Year Published: 2019Topics: Analgesia, Anesthesia & SedationAnimal Type: Fish, Shark & Ray

Citation: Martins, T., Valentim, A., Pereira, N. et al. 2019. Anaesthetics and analgesics used in adult fish for research: A review. Laboratory Animals 53(4), 325–341.

Sedative, analgesic, and behavioral effects of nalbuphine-xylazine and nalbuphine-midazolam combinations in dogs

The purpose of the present study was to evaluate the sedative, analgesic, and behavioral effects of nalbuphine-xylazine (NX) and nalbuphine-midazolam (NM) combinations for neuroleptanalgesia in dogs. A prospective randomized crossover study was done on six adult mongrel dogs. Dogs were...

Year Published: 2018Topics: AnalgesiaAnimal Type: Dog

Citation: Torad, F. A., Hassan, E. A. 2018. Sedative, analgesic, and behavioral effects of nalbuphine-xylazine and nalbuphine-midazolam combinations in dogs. Journal of Veterinary Behavior 28, 40-45.

Ethical considerations in fish research

In this review, we focus primarily on the refinement of common methods used in fish research based on emerging knowledge with the aim of improving the welfare of fish used in scientific studies. We consider the use of anaesthetics and...

Year Published: 2019Topics: Analgesia, Anesthesia & Sedation, Husbandry & ManagementAnimal Type: Fish, Other Fish, Salmon, Tilapia, Trout, Zebrafish

Citation: Sloman, K, A., Bouyoucos, I. A., Brooks, E. J. et al. 2019. Ethical considerations in fish research. Journal of Fish Biology 94(4), 556-577.

The controversy on fish pain: A veterinarian’s perspective

Fish welfare is still a relatively new field. As such, regulations and protocols to ensure fish welfare are currently limited and vary considerably in different jurisdictions. This is in part because of the ongoing controversy as to whether or not...

Year Published: 2019Topics: Analgesia, Natural Behavior, Welfare AssessmentAnimal Type: Fish, Other Fish, Salmon, Tilapia, Trout, Zebrafish

Citation: Chatigny, F. 2019. The controversy on fish pain: A veterinarian's perspective. Journal of Applied Animal Welfare Science 22(4), 400-410.

Evaluation of analgesic patches in cynomolgus macaques (Macaca fascicularis)

Opioids are widely used in veterinary and human medicine to manage pain. However, there is a paucity of information in the literature regarding the pharmacokinetics of opioid transdermal patches (TDP) in NHP. Therefore, to determine whether opioid TDP attain therapeutic...

Year Published: 2019Topics: AnalgesiaAnimal Type: Macaque, Nonhuman Primate

Citation: Smith, A. A., Halliday, L. C., Lindeblad, M. O. et al. 2019. Evaluation of analgesic patches in cynomolgus macaques (Macaca fascicularis). JAALAS 58(3), 356-361.

Preliminary evaluation of sustained-release compared with conventional formulations of meloxicam in sheep (Ovis aries)

Sustained-release (SR) drugs refine current analgesic regimens by alleviating the need for multiple sessions of handling and restraint and by reducing the local tissue irritation that can occur due to repeated injections. Although a variety of SR drugs are already...

Year Published: 2019Topics: AnalgesiaAnimal Type: Sheep

Citation: Dunbar, M. L., Walkowiak, K. J., Schappa Faustich, J. et al. 2019. Preliminary evaluation of sustained-release compared with conventional formulations of meloxicam in sheep (Ovis aries). JAALAS 58(3), 339-345.

Assessing the affective component of pain, and the efficacy of pain control, using conditioned place aversion in calves

Pain in animals is typically assessed using reflexive and physiological responses. These measures allow inferences regarding nociception but provide little basis for conclusions about the affective component of pain (i.e. how negatively the experience is perceived). Calves routinely undergo painful...

Year Published: 2019Topics: Analgesia, Body Modification/MutilationAnimal Type: Cattle

Citation: Ede, T., von Keyserlingk, M. A. G., Weary, D. M. 2019. Assessing the affective component of pain, and the efficacy of pain control, using conditioned place aversion in calves. Biology Letters 15(10), 20190642.

Sustained-release buprenorphine improves postsurgical clinical condition but does not alter survival or cytokine levels in a murine model of polymicrobial sepsis

Cecal ligation and perforation (CLP) is a common technique for studying sepsis in mice. Because of the invasiveness of the procedure and its effects on clinical condition, many animal care and use committees require the use of analgesics with CLP....

Year Published: 2016Topics: Analgesia, Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Herndon, N. L., Bandyopadhyay, S., Hod, E. A. et al. 2016. Sustained-release buprenorphine improves postsurgical clinical condition but does not alter survival or cytokine levels in a murine model of polymicrobial sepsis. Comparative Medicine 66(6), 455–462.

To treat or not to treat: The effects of pain on experimental parameters

A common dilemma faced by all animal bioethics committees arises when exceptions are proposed to the use of analgesics in painful procedures. The committee and researcher must weigh the possible confounding effects of including additional drugs (analgesics) in their treatment...

Year Published: 2017Topics: AnalgesiaAnimal Type: All/General

Citation: Peterson, N. C., Nunamaker, E. A., Turner, P. V. 2017. To treat or not to treat: The effects of pain on experimental parameters. Comparative Medicine 67(6), 469–482.

Anaesthetic and perioperative management of 14 male New Zealand white rabbits for calvarial bone surgery

Calvarial bone surgery on rabbits is frequently performed. This report aims to document a simple and practical anaesthetic and perioperative management for this procedure. Fourteen male New Zealand white rabbits were included in the study. Subcutaneous (SC) dexmedetomidine, ketamine and...

Year Published: 2019Topics: Analgesia, Anesthesia & Sedation, Disease/Experimental ModelAnimal Type: Rabbit

Citation: Raillard, M., Detotto, C., Grepper, S. et al. 2019. Anaesthetic and perioperative management of 14 male New Zealand white rabbits for calvarial bone surgery. Animals 9(11), 896.