Analgesia

Self-administration by consumption of flunixin in feed alleviates the pain and inflammation associated with castration and tail docking of lambs

It can be impractical for farmers to provide pain relief to livestock following husbandry procedures such as castration and tail-docking, particularly in pasture-based systems because animals need to be repeatedly gathered to handling facilities and restrained. We investigated whether voluntary...

Year Published: 2017Topics: AnalgesiaAnimal Type: Sheep

Citation: Marini, D., Colditz, I. G., Hinch, G. et al. 2017. Self-administration by consumption of flunixin in feed alleviates the pain and inflammation associated with castration and tail docking of lambs. Applied Animal Behaviour Science 188, 26-33.

Impact of analgesic drugs on the behavioural responses of larval zebrafish to potentially noxious temperatures

Recent studies have demonstrated that fish exhibit behavioural responses to noxious stimuli, including mechanical, chemical or thermal stimulation. In many cases, these responses are characterised by a reduction in the locomotor activity, which in turn can be ameliorated by using...

Year Published: 2017Topics: AnalgesiaAnimal Type: Fish, Zebrafish

Citation: Lopez-Luna, J., Al-Jubouri, Q., Al-Nuaimy, W. et al. 2017. Impact of analgesic drugs on the behavioural responses of larval zebrafish to potentially noxious temperatures. Applied Animal Behaviour Science 188, 97-105.

Exploring the efficacy of immersion analgesics in zebrafish using an integrative approach

Home Office guidelines recommend the use of analgesics for all protected species, including fish during scientific procedures likely to result in pain, suffering, distress and lasting harm. In larger fish species some drugs have shown efficacy in terms of perioperative...

Year Published: 2017Topics: AnalgesiaAnimal Type: Fish, Zebrafish

Citation: Schroeder, P. G., Sneddon, L. U. 2017. Exploring the efficacy of immersion analgesics in zebrafish using an integrative approach. Applied Animal Behaviour Science 187, 93-102.

Buprenorphine via drinking water and combined oral-injection protocols for pain relief in mice

Buprenorphine is the opioid analgesic most commonly used in laboratory mice. However, to maintain therapeutically effective serum levels, repeated injections are required. To overcome negative aspects of restraint and injection, oral self-administration is a promising alternative but has been criticized...

Year Published: 2016Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Sauer, M., Fleischmann, T., Lipiski, M. et al. 2016. Buprenorphine via drinking water and combined oral-injection protocols for pain relief in mice. Applied Animal Behaviour Science 185, 103-112.

Behavioural responses of fish larvae modulated by analgesic drugs after a stress exposure

Fish are known to respond to a wide range of irritant chemicals, displaying clear behavioural changes after exposure to potentially noxious stimuli. Recent evidence shows that these agents can have an impact on larval forms of fish. However, very little...

Year Published: 2017Topics: AnalgesiaAnimal Type: Fish, Zebrafish

Citation: Lopez-Luna, J., Canty, M. N., Al-Jubouri, Q. et al. 2017. Behavioural responses of fish larvae modulated by analgesic drugs after a stress exposure. Applied Animal Behaviour Science 195, 115-120.

Tramadol:Paracetamol in drinking water for treatment of post-surgical pain in laboratory mice

In the search for stress-free analgesia administration for laboratory mice suffering pain, oral delivery of Tramadol:Paracetamol (T:P) shows great promise. Here, we monitored the analgesic efficacy and side effects of a T:P combination administered solely in the drinking water of...

Year Published: 2018Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Jirkof, P., Arras, M., Cesarovic, N. 2018. Tramadol:Paracetamol in drinking water for treatment of post-surgical pain in laboratory mice. Applied Animal Behaviour Science 198, 95-100.

Evaluating environmental enrichment as a method to alleviate pain after castration and tail docking in pigs

Castration and tail docking are common management practices performed on commercial swine farms in the US and around the world to reduce adverse behaviors and the occurrence of boar taint. However, these practices themselves are a welfare concern for the...

Year Published: 2018Topics: Analgesia, Body Modification/Mutilation, Environmental EnrichmentAnimal Type: Pig

Citation: Backus, B. L., McGlone, J. J. 2018. Evaluating environmental enrichment as a method to alleviate pain after castration and tail docking in pigs. Applied Animal Behaviour Science 204, 37-42.

3Rs improvements in the Bexsero® (Meningitis B) vaccine

Bexsero® is a new vaccine in the UK which since September 2015 has been added to the childhood immunisation programme for the prevention of Meningitis B. The in-vivo test as performed in Biological Services Division (BSD) uses female CD1 mice...

Year Published: 2017Topics: Analgesia, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Ferguson, R. 3Rs improvements in the Bexsero® (Meningitis B) vaccine. Animal Technology and Welfare 16(2), 150-152.

Efficacy of common analgesics for postsurgical pain in rats

I have some comments about the use of ketoprofen for analgesia in rats discussed in the recent JAALASarticle by Waite and colleagues.3 One of the conclusions reached by the authors was that, for postsurgical pain, “ketoprofen was effective when given...

Year Published: 2016Topics: AnalgesiaAnimal Type: Rat, Rodent

Citation: Shientag, L. J. 2016. Efficacy of common analgesics for postsurgical pain in rats. JAALAS 55(1), 7.

Effects of buprenorphine, methylnaltrexone, and their combination on gastrointestinal transit in healthy New Zealand White rabbits

Among the many analgesic agents available, buprenorphine appears to be the analgesic used most often in rabbits. Unfortunately, deleterious side effects of opioids, such as gastrointestinal stasis and anorexia, may discourage the use of these agents. Methylnaltrexone is a peripheral...

Year Published: 2017Topics: AnalgesiaAnimal Type: Rabbit

Citation: Martin-Flores, M., Singh, B., Walsh, C. A. 2017. Effects of buprenorphine, methylnaltrexone, and their combination on gastrointestinal transit in healthy New Zealand White rabbits. JAALAS 56(2), 155-159.