Analgesia

Behavioural responses of fish larvae modulated by analgesic drugs after a stress exposure

Fish are known to respond to a wide range of irritant chemicals, displaying clear behavioural changes after exposure to potentially noxious stimuli. Recent evidence shows that these agents can have an impact on larval forms of fish. However, very little...

Year Published: 2017Topics: AnalgesiaAnimal Type: Fish, Zebrafish

Citation: Lopez-Luna, J., Canty, M. N., Al-Jubouri, Q. et al. 2017. Behavioural responses of fish larvae modulated by analgesic drugs after a stress exposure. Applied Animal Behaviour Science 195, 115-120.

Tramadol:Paracetamol in drinking water for treatment of post-surgical pain in laboratory mice

In the search for stress-free analgesia administration for laboratory mice suffering pain, oral delivery of Tramadol:Paracetamol (T:P) shows great promise. Here, we monitored the analgesic efficacy and side effects of a T:P combination administered solely in the drinking water of...

Year Published: 2018Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Jirkof, P., Arras, M., Cesarovic, N. 2018. Tramadol:Paracetamol in drinking water for treatment of post-surgical pain in laboratory mice. Applied Animal Behaviour Science 198, 95-100.

Evaluating environmental enrichment as a method to alleviate pain after castration and tail docking in pigs

Castration and tail docking are common management practices performed on commercial swine farms in the US and around the world to reduce adverse behaviors and the occurrence of boar taint. However, these practices themselves are a welfare concern for the...

Year Published: 2018Topics: Analgesia, Body Modification/Mutilation, Environmental EnrichmentAnimal Type: Pig

Citation: Backus, B. L., McGlone, J. J. 2018. Evaluating environmental enrichment as a method to alleviate pain after castration and tail docking in pigs. Applied Animal Behaviour Science 204, 37-42.

3Rs improvements in the Bexsero® (Meningitis B) vaccine

Bexsero® is a new vaccine in the UK which since September 2015 has been added to the childhood immunisation programme for the prevention of Meningitis B. The in-vivo test as performed in Biological Services Division (BSD) uses female CD1 mice...

Year Published: 2017Topics: Analgesia, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Ferguson, R. 3Rs improvements in the Bexsero® (Meningitis B) vaccine. Animal Technology and Welfare 16(2), 150-152.

Efficacy of common analgesics for postsurgical pain in rats

I have some comments about the use of ketoprofen for analgesia in rats discussed in the recent JAALASarticle by Waite and colleagues.3 One of the conclusions reached by the authors was that, for postsurgical pain, “ketoprofen was effective when given...

Year Published: 2016Topics: AnalgesiaAnimal Type: Rat, Rodent

Citation: Shientag, L. J. 2016. Efficacy of common analgesics for postsurgical pain in rats. JAALAS 55(1), 7.

Effects of buprenorphine, methylnaltrexone, and their combination on gastrointestinal transit in healthy New Zealand White rabbits

Among the many analgesic agents available, buprenorphine appears to be the analgesic used most often in rabbits. Unfortunately, deleterious side effects of opioids, such as gastrointestinal stasis and anorexia, may discourage the use of these agents. Methylnaltrexone is a peripheral...

Year Published: 2017Topics: AnalgesiaAnimal Type: Rabbit

Citation: Martin-Flores, M., Singh, B., Walsh, C. A. 2017. Effects of buprenorphine, methylnaltrexone, and their combination on gastrointestinal transit in healthy New Zealand White rabbits. JAALAS 56(2), 155-159.

Pharmacokinetic profiles of meloxicam and sustained-release buprenorphine in prairie dogs (Cynomys ludovicianus)

In this study, we evaluated the pharmacokinetic profiles of meloxicam and sustained-release (SR) buprenorphine in prairie dogs. The 4 treatment groups were: low-dose meloxicam (0.2 mg/kg SC), high-dose meloxicam (4 mg/kg SC), low-dose buprenorphine SR (0.9 mg/kg SC), and high-dose...

Year Published: 2017Topics: AnalgesiaAnimal Type: Other Rodent, Rodent

Citation: Cary, C. D., Lukovsky-Akhsanov, N. L., Gallardo-Romero, N. F. et al. 2017. Pharmacokinetic profiles of meloxicam and sustained-release buprenorphine in prairie dogs (Cynomys ludovicianus). JAALAS 56(2), 160-165.

Use of liposomal bupivacaine for postoperative analgesia in an incisional pain model in rats (Rattus norvegicus)

The local anesthetic bupivacaine is valuable for perioperative analgesia, but its use in the postoperative period is limited by its short duration of action. Here, we evaluated the application of a slow-release liposomal formulation of bupivacaine for postoperative analgesia. The...

Year Published: 2017Topics: AnalgesiaAnimal Type: Rat, Rodent

Citation: Kang, S. C., Jampachaisri, K., Seymour, T. L. et al. 2017. Use of liposomal bupivacaine for postoperative analgesia in an incisional pain model in rats (Rattus norvegicus). JAALAS 56(1), 63-68.

Efficacy of sustained-release buprenorphine in an experimental laparotomy model in female mice

Mice purportedly require dosing with the opioid buprenorphine (Bup-HCl) at least every 8 to 12 h to maintain an adequate plane of analgesia. Here we used an experimental laparotomy model to determine the clinical efficacy of sustained-release formulations of buprenorphine...

Year Published: 2016Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Kendall, L. V., Wegenast, D. J., Smith, B. J. et al. 2016. Efficacy of sustained-release buprenorphine in an experimental laparotomy model in female mice. JAALAS 55(1), 66–73.

Analgesic activity of tramadol and buprenorphine after voluntary ingestion by rats (Rattus norvegicus)

Effective pain management for rats and mice is crucial due to the continuing increase in the use of these species in biomedical research. Here we used a recently validated operant orofacial pain assay to determine dose–response curves for buprenorphine and...

Year Published: 2016Topics: AnalgesiaAnimal Type: Rat, Rodent

Citation: Taylor, B. F., Ramirez, H. E., Battles, A. H. et al. 2016. Analgesic activity of tramadol and buprenorphine after voluntary ingestion by rats (Rattus norvegicus). JAALAS, 55(1), 74–82.