Publications

Is music enriching for group-housed captive chimpanzees (Pan troglodytes)?

Many facilities that house captive primates play music for animal enrichment or for caregiver enjoyment. However, the impact on primates is unknown as previous studies have been inconclusive. We conducted three studies with zoo-housed chimpanzees (Pan troglodytes) and one with...

Year Published: 2017Topics: Environmental EnrichmentAnimal Type: Chimpanzee, Nonhuman Primate

Citation: Wallace, E. K., Altschul, D., Körfer, K. et al. 2017. Is music enriching for group-housed captive chimpanzees (Pan troglodytes)? PLOS ONE 12(3), e0172672.

Enriched environment and stress exposure influence splenic B lymphocyte composition

Prolonged chronic stress has deleterious effects on immune function and is associated with numerous negative health outcomes. The spleen harbors one-fourth of the body's lymphocytes and mediates both innate and adaptive immune responses. However, the subset of splenic lymphocytes that...

Year Published: 2017Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Gurfein, B. T., Hasdemir, B., Milush, J. M. et al. 2017. Enriched environment and stress exposure influence splenic B lymphocyte composition. PLOS ONE 12(7), e0180771.

The use of preferred social stimuli as rewards for rhesus macaques in behavioural neuroscience

Macaques are often motivated to perform in neuroscientific experiments by implementing fluid restriction protocols. Daily access to water is controlled and the monkeys are rewarded with droplets of fluid for performing correct trials in the laboratory. Although these protocols are...

Year Published: 2017Topics: Animal TrainingAnimal Type: Macaque, Nonhuman Primate

Citation: Gray, H., Pearce, B., Thiele, A. 2017. The use of preferred social stimuli as rewards for rhesus macaques in behavioural neuroscience. PLOS ONE 12(5), e0178048.

Assessment of housing density, space allocation and social hierarchy of laboratory rats on behavioural measures of welfare

Minimum space allowances for laboratory rats are legislated based on weight and stocking rates, with the understanding that increased housing density encourages crowding stress. However, there is little evidence for these recommendations, especially when considering positive welfare outcomes. This study...

Year Published: 2017Topics: Social Housing & Companionship, Stocking DensityAnimal Type: Rat, Rodent

Citation: Barker, T. H., George, R. P., Howarth, G. S. et al. 2017. Assessment of housing density, space allocation and social hierarchy of laboratory rats on behavioural measures of welfare. PLOS ONE 12(9), e0185135.

Low plasma cortisol and fecal cortisol metabolite measures as indicators of compromised welfare in domestic horses (Equus caballus)

The hypothalamic-pituitary-adrenal (HPA) axis response to chronic stress is far from straight forward, particularly with regards to animal welfare. There are reports of no effect as well as both decreases and increases in cortisol after chronic stressors. Therefore, the first...

Year Published: 2017Topics: Welfare AssessmentAnimal Type: Equine

Citation: Pawluski, J., Jego, P., Henry, S. et al. 2017. Low plasma cortisol and fecal cortisol metabolite measures as indicators of compromised welfare in domestic horses (Equus caballus). PLOS ONE 12(9), e0182257.

A link between damaging behaviour in pigs, sanitary conditions, and dietary protein and amino acid supply

The tendency to reduce crude protein (CP) levels in pig diets to increase protein efficiency may increase the occurrence of damaging behaviours such as ear and tail biting, particularly for pigs kept under suboptimal health conditions. We studied, in a...

Year Published: 2017Topics: Husbandry & ManagementAnimal Type: Pig

Citation: van der Meer, Y., Gerrits, W. J. J., Jansman, A. J. M. 2017. A link between damaging behaviour in pigs, sanitary conditions, and dietary protein and amino acid supply. PLOS ONE 12(5), e0174688.

The Sheep Grimace Scale as an indicator of post-operative distress and pain in laboratory sheep

The EU Directive 2010/63/EU changed the requirements regarding the use of laboratory animals and raised important issues related to assessing the severity of all procedures undertaken on laboratory animals. However, quantifiable parameters to assess severity are rare, and improved assessment...

Year Published: 2017Topics: Welfare AssessmentAnimal Type: Sheep

Citation: Häger, C., Biernot, S., Buettner, M. et al. 2017. The Sheep Grimace Scale as an indicator of post-operative distress and pain in laboratory sheep. PLOS ONE 12(4), e0175839.

Severity classification of repeated isoflurane anesthesia in C57BL/6JRj mice—Assessing the degree of distress

According to the EU Directive 2010/63, the severity of a procedure has to be classified as mild, moderate or severe. General anesthesia is thought to be mild, but the Directive does not differentiate between single and repeated anesthesia. Therefore, we...

Year Published: 2017Topics: Anesthesia & SedationAnimal Type: Mouse, Rodent

Citation: Hohlbaum, K., Bert, B., Dietze, S. et al. 2017. Severity classification of repeated isoflurane anesthesia in C57BL/6JRj mice—Assessing the degree of distress. PLOS ONE 12(6), e0179588.

How do rehomed laboratory Beagles behave in everyday situations? Results from an observational test and a survey of new owners

When laboratory dogs are rehomed into private households, they experience an extreme change in their life situation. They leave their familiar, limited environment in the research facility and encounter a multitude of animate and inanimate stimuli in their new home....

Year Published: 2017Topics: Relocation & TransportAnimal Type: Dog

Citation: Döring, D., Nick, O., Bauer, A. et al. 2017. How do rehomed laboratory Beagles behave in everyday situations? Results from an observational test and a survey of new owners. PLOS ONE 12(7), e0181303.

Effects of transportation, relocation, and acclimation on phenotypes and functional characteristics of peripheral blood lymphocytes in rhesus monkeys (Macaca mulatta)

Nonhuman primates from domestic sources constitute a small, but critical, proportion of animals studied in research laboratories. Many of these nonhuman primates are raised at one facility and subsequently transported/relocated to another facility for research purposes. We examined the effects...

Year Published: 2017Topics: Relocation & TransportAnimal Type: Macaque, Nonhuman Primate

Citation: Nehete, P. N., Shelton, K. A., Nehete, B. P. et al. 2017. Effects of transportation, relocation, and acclimation on phenotypes and functional characteristics of peripheral blood lymphocytes in rhesus monkeys (Macaca mulatta). PLOS ONE 12(12), e0188694.