Publications

Evaluation of low versus high volume per minute displacement CO2 methods of euthanasia in the induction and duration of panic-associated behavior and physiology

Current recommendations for the use of CO 2 as a euthanasia agent for rats require the use of gradual fill protocols (such as 10% to 30% volume displacement per minute) in order to render the animal insensible prior to exposure...

Year Published: 2016Topics: EuthanasiaAnimal Type: Rat, Rodent

Citation: Hickman, D., Fitz, S., Bernabe, C. et al. 2016. Evaluation of low versus high volume per minute displacement CO2 methods of euthanasia in the induction and duration of panic-associated behavior and physiology. Animals 6(8), 45.

Effects of various cleaning agents on the performance of mice in behavioral assays of anxiety

Cleaning behavioral equipment between rodent subjects is important to prevent disease transmission and reduce odor cues from previous subjects. However, the reporting regarding the cleansing procedures used during such experiments is sporadic and often incomplete. In addition, some investigators are...

Year Published: 2018Topics: Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Hershey, J. D., Gifford, J. J., Zizza, L. J. et al. 2018. Effects of various cleaning agents on the performance of mice in behavioral assays of anxiety. JAALAS 57(4), 335-339.

Effects of nesting material on the toxicologic assessment of cyclophosphamide in Crl:CD1(ICR) mice

The provision of nesting material benefits mice by reducing cold stress, improving feed conversion, increasing litter size, and improving adaptive immunity. The effects of toxins are sensitive to environmental changes, and the introduction of novel items can alter results in...

Year Published: 2018Topics: Environmental Enrichment, Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Brochu, C. P., Winnicker, C. L., Provencher, A. L. et al. 2018. Effects of nesting material on the toxicologic assessment of cyclophosphamide in Crl:CD1(ICR) mice. JAALAS 57(4), 340-349.

Effect of chronic social stress on prenatal transfer of antitetanus immunity in captive breeding rhesus macaques (Macaca mulatta)

Because tetanus can cause significant morbidity and mortality in NHP, colonywide vaccination with tetanus toxoid is recommended for outdoor breeding colonies of rhesus macaques, with primary immunizations commonly given to infants at 6 mo of age followed by booster vaccines...

Year Published: 2018Topics: Reproduction, Social Housing & CompanionshipAnimal Type: Macaque, Nonhuman Primate

Citation: Stammen, R. L., Cohen, J. K., Meeker, T. L. et al. 2018. Effect of chronic social stress on prenatal transfer of antitetanus immunity in captive breeding rhesus macaques (Macaca mulatta). JAALAS 57(4), 357-367.

Analgesic efficacy of subcutaneous–oral dosage of tramadol after surgery in C57BL/6J mice

This study investigated the analgesic activity of tramadol in female C57BL/6J mice by using a single subcutaneous injection (25 mg/kg) of tramadol combined with the same dose given in drinking water for 24 h. We then evaluated the pharmacokinetics of...

Year Published: 2018Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Evangelista-Vaz, R., Bergadano, A., Arras, M. et al. 2018. Analgesic efficacy of subcutaneous–oral dosage of tramadol after surgery in C57BL/6J mice. JAALAS 57(4), 368-375.

Comparison of serial blood collection by facial vein and retrobulbar methods in C57BL/6 mice

Many biomedical research protocols for mouse models involve serial blood collection and analysis. Two common techniques for serial blood collection in this species are the retrobulbar (RB, also called retroorbital) and facial vein (FV) methods. However, previous studies comparing these...

Year Published: 2018Topics: Biological Sampling & Physiological MeasurementAnimal Type: Mouse, Rodent

Citation: Frohlich, J. R., Alarcón, C. N., Toarmino, C. R. et al. 2018. Comparison of serial blood collection by facial vein and retrobulbar methods in C57BL/6 mice. JAALAS 57(4), 382-391.

Use of air-activated thermal devices during recovery after surgery in mice

Laboratory mice (Mus musculus) are susceptible to hypothermia, especially during anesthetic events, disease states, and exposure to environmental stressors. Thermal support devices for small mammals are numerous, but often require a power source and may be impractical to use for...

Year Published: 2018Topics: Surgery & Post-OpAnimal Type: Mouse, Rodent

Citation: Beale, C. N., Esmail, M. Y., Aguiar, A. M. et al. 2018. Use of air-activated thermal devices during recovery after surgery in mice. JAALAS 57(4), 392-400.

Effect of environmental enrichment on aggression in BALB/cJ and BALB/cByJ mice monitored by using an automated system

Aggression among mice remains a common undesirable problem in laboratory settings, and animal welfare and scientific outcomes may become compromised depending on the severity of aggression. This study evaluated the effect of cage enrichment comprising a bilevel, mounted 'mezzanine' compared...

Year Published: 2018Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Giles, J. M., Whitaker, J. W., Moy, S. S. et al. 2018. Effect of environmental enrichment on aggression in BALB/cJ and BALB/cByJ mice monitored by using an automated system. JAALAS 57(3), 236-243.

Analgesic efficacy and hematologic effects of robenacoxib in mice

NSAID analgesics may confound models that require inflammation to mimic disease development in humans. This effect presents a challenge for veterinary staff and investigators, because surgery is often necessary to create mouse models of disease and NSAID are first-line analgesics...

Year Published: 2018Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Beninson, J. A., Lofgren, J. L., Lester, P. A. et al. 2018. Analgesic efficacy and hematologic effects of robenacoxib in mice. JAALAS 57(3), 258-267.

Analgesic efficacy and safety of buprenorphine in chinchillas (Chinchilla lanigera)

Buprenorphine is routinely used in chinchillas at reported doses of 0.01 to 0.1 mg/kg IM or SC. However, these dose recommendations are based on anecdotal reports or extrapolation from studies in other species. Therefore, the purpose of this study was...

Year Published: 2018Topics: AnalgesiaAnimal Type: Chinchilla, Rodent

Citation: Fox, L., Mans, C. 2018. Analgesic efficacy and safety of buprenorphine in chinchillas (Chinchilla lanigera). JAALAS 57(3), 286-290.