Publications

Four- and six-hour urinary albumin excretion is a valuable alternative to 24-h urinary albumin excretion in male db/db mice

In mouse (Mus musculus) models of diabetic nephropathy (DN), one of the most important read-outs is the 24-h urinary albumin excretion (UAE). The 24-h urine collection is usually performed by single housing mice in metabolic cages on wire mesh without...

Year Published: 2020Topics: Biological Sampling & Physiological Measurement, Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Nøgaard, S. A., Sand, F. W., Sørensen, D. B. et al. 2020. Four- and six-hour urinary albumin excretion is a valuable alternative to 24-h urinary albumin excretion in male db/db mice. Animal Welfare 29(2), 143-149.

Frothy saliva—A novel indicator to assess stereotypies in sows?

The present study aimed at introducing a reliable and more feasible indicator to evaluate stereotypies in sows in comparison with the Welfare Quality® animal welfare assessment protocol for sows and piglets’. Therefore, the indicators for the assessment of stereotypies of...

Year Published: 2020Topics: Abnormal/Problematic Behavior, Welfare AssessmentAnimal Type: Pig

Citation: Friedrich, L., Krieter, J., Kemper, N. et al. 2020. Frothy saliva—A novel indicator to assess stereotypies in sows? Applied Animal Behaviour Science 222, 104897.

Gastrostomy tube placement via a laparotomic procedure in growing conventional piglets to perform multidose preclinical paediatric drug studies

The use of juvenile conventional pigs as a preclinical animal model to perform pharmacokinetic (PK), pharmacodynamic (PD) and safety studies for the paediatric population is increasing. Repetitive oral administration of drugs to juvenile pigs is however challenging. A representative method...

Year Published: 2020Topics: Drug/Substance AdministrationAnimal Type: Pig

Citation: Millecam, J., van Bergen, T., Devreese, M. 2020. Gastrostomy tube placement via a laparotomic procedure in growing conventional piglets to perform multidose preclinical paediatric drug studies. Laboratory Animals 54(3), 261-271.

High laboratory mouse pre-weaning mortality associated with litter overlap, advanced dam age, small and large litters

High and variable pre-weaning mortality is a persistent problem in laboratory mouse breeding. Assuming a modest 15% mortality rate across mouse strains, means that approximately 1 million more pups are produced yearly in the EU to compensate for those which...

Year Published: 2020Topics: Husbandry & Management, Rearing & WeaningAnimal Type: Mouse, Rodent

Citation: Morello, G. M., Hultgren, J., Capas-Peneda, S. et al. 2020. High laboratory mouse pre-weaning mortality associated with litter overlap, advanced dam age, small and large litters. PLOS ONE 15(8): e0236290.

Identifying obstacles preventing the uptake of tunnel handling methods for laboratory mice: An international thematic survey

Handling of laboratory mice is essential for experiments and husbandry, but handling can increase anxiety in mice, compromising their welfare and potentially reducing replicability between studies. The use of non-aversive handling (e.g., tunnel handling or cupping), rather than the standard...

Year Published: 2020Topics: HandlingAnimal Type: Mouse, Rodent

Citation: Henderson, L. J., Smulders, T. V., Roughan, J. V. 2020. Identifying obstacles preventing the uptake of tunnel handling methods for laboratory mice: An international thematic survey. PLOS ONE 15(4), e0231454.

Impact of a cattle brush on feedlot steer behavior, productivity, and stress physiology

The aim of the present study was to investigate the impact of environmental enrichment (EE), in the form of a cattle brush, on feedlot cattle behavior, productivity and stress physiology. Steers were blocked by weight and assigned to one of...

Year Published: 2020Topics: Abnormal/Problematic Behavior, Environmental EnrichmentAnimal Type: Cattle

Citation: Park, R. M., Schubach, K. M., Cooke, R. F. et al. 2020. Impact of a cattle brush on feedlot steer behavior, productivity and stress physiology. Applied Animal Behaviour Science 228, 104995.

Impact of enriched environment during adolescence on adult social behavior, hippocampal synaptic density and dopamine D2 receptor expression in rats

Environmental enrichment (EE) is one experimental manipulation that induces changes in the brain. However, it is important to distinguish between physical and social components of enrichment. To this end we established four groups of rats reared in different enriched environments...

Year Published: 2020Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Gabriel, P., Mastracchio, T., Bordner, K. et al. 2020. Impact of enriched environment during adolescence on adult social behavior, hippocampal synaptic density and dopamine D2 receptor expression in rats. Physiology & Behavior, 226, 113133.

Impact of environmental enrichment and social group size in the aggressiveness and foraging activity of Serrapinnus notomelas

Fish are widely used in scientific research, and many species are bred for ornamental purposes and human consumption. Despite the large number of fish kept in captivity, research on the welfare of these animals has only recently intensified. One commonly...

Year Published: 2020Topics: Environmental EnrichmentAnimal Type: Fish, Other Fish

Citation: da Silva, A., Lima, M. R., Meletti, P. C. et al. 2020. Impact of environmental enrichment and social group size in the aggressiveness and foraging activity of Serrapinnus notomelas. Applied Animal Behaviour Science 224, 104943.

Impact of euthanasia on compassion fatigue in personnel working in animal research

We conducted a cross-sectional study to investigate the association between euthanasia and compassion fatigue among employees working in animal research at a large academic medical center. In summary, animal research workers who euthanize animals reported significantly more burnout and traumatic...

Year Published: 2020Topics: Euthanasia, Human-Animal InteractionAnimal Type: All/General

Citation: Gades, N. M., Thompson, K. L., Mi, L. et al. 2020. Impact of euthanasia on compassion fatigue in personnel working in animal research. Laboratory Animal Science Professional 8(1) (January/February), 22-23.

Impact of flooring type on the sham dustbathing behaviour of caged laying hens

Feed particles are preferred for foraging and they are also a stimulus for sham dustbathing. Most sham dustbathing bouts start with bill raking in the feed by caged hens. As hens often exhibit a floor scratching behaviour, an element of...

Year Published: 2020Topics: Housing, Husbandry & Management, Natural BehaviorAnimal Type: Bird, Chicken

Citation: Moroki, Y. 2020. Impact of flooring type on the sham dustbathing behaviour of caged laying hens. Applied Animal Behaviour Science 230, 105066.