Publications

Survey of behavioral indices of welfare in research chimpanzees (Pan troglodytes) in the United States

Chimpanzees demand specialized housing and care and the highest degree of attention to animal welfare. The current project used a survey method to collate information on chimpanzee housing and behavioral indices of welfare across all 6 of the chimpanzee research...

Year Published: 2019Topics: Abnormal/Problematic Behavior, Animal Training, Environmental Enrichment, Housing, Husbandry & ManagementAnimal Type: Chimpanzee, Nonhuman Primate

Citation: Bloomsmith, M. A., Clay, A. W., Lambeth, S. P. et al. 2019. Survey of behavioral indices of welfare in research chimpanzees (Pan troglodytes) in the United States. JAALAS 58(2), 160-177.

Preliminary evaluation of sustained-release compared with conventional formulations of meloxicam in sheep (Ovis aries)

Sustained-release (SR) drugs refine current analgesic regimens by alleviating the need for multiple sessions of handling and restraint and by reducing the local tissue irritation that can occur due to repeated injections. Although a variety of SR drugs are already...

Year Published: 2019Topics: AnalgesiaAnimal Type: Sheep

Citation: Dunbar, M. L., Walkowiak, K. J., Schappa Faustich, J. et al. 2019. Preliminary evaluation of sustained-release compared with conventional formulations of meloxicam in sheep (Ovis aries). JAALAS 58(3), 339-345.

Evaluation of analgesic patches in cynomolgus macaques (Macaca fascicularis)

Opioids are widely used in veterinary and human medicine to manage pain. However, there is a paucity of information in the literature regarding the pharmacokinetics of opioid transdermal patches (TDP) in NHP. Therefore, to determine whether opioid TDP attain therapeutic...

Year Published: 2019Topics: AnalgesiaAnimal Type: Macaque, Nonhuman Primate

Citation: Smith, A. A., Halliday, L. C., Lindeblad, M. O. et al. 2019. Evaluation of analgesic patches in cynomolgus macaques (Macaca fascicularis). JAALAS 58(3), 356-361.

Association of Primate Veterinarians’ guidelines for nonhuman primate restraint

The Association of Primate Veterinarians (APV) recognizes that several forms of restraint, including physical and chemical, are necessary for the safe handling of nonhuman primates (NHPs). The following guidelines aim to provide information to researchers, animal caregivers, veterinarians, and institutional...

Year Published: 2019Topics: RestraintAnimal Type: Baboon, Capuchin, Chimpanzee, Lemur, Macaque, Marmoset, Nonhuman Primate, Other Nonhuman Primate, Owl Monkey, Squirrel Monkey, Vervet (African Green Monkey)

Citation: Association of Primate Veterinarians. 2019. Association of Primate Veterinarians' guidelines for nonhuman primate restraint. JAALAS 58(3), 282-284.

Time-dependent pathologic and inflammatory consequences of various blood sampling techniques in mice

We compared 6 frequently used mouse blood-sampling methods (lateral tail incision; tail-tip amputation; sublingual, submandibular, and saphenous vein puncture; and retrobulbar sinus puncture during isoflurane anesthesia) with regard to induction of local and systemic inflammation, stomach contents, weight changes, and...

Year Published: 2019Topics: Biological Sampling & Physiological MeasurementAnimal Type: Mouse, Rodent

Citation: Sørensen, D. B., Metzdorff, S. B., Jensen, L. K. et al. 2019. Time-dependent pathologic and inflammatory consequences of various blood sampling techniques in mice. JAALAS 58(3), 362-372.

Assessment of pain associated with the injection of sodium pentobarbital in laboratory mice (Mus musculus)

The AVMA Guidelines for the Euthanasia of Animals considers injection of barbiturates to be an acceptable method of euthanasia in rodents but states there is a potential for pain when administered intraperitoneally. This study examined the potential for pain in...

Year Published: 2019Topics: Drug/Substance Administration, EuthanasiaAnimal Type: Mouse, Rodent

Citation: Dutton III, J. W., Artwohl, J. E., Huang, X. et al. 2019. Assessment of pain associated with the injection of sodium pentobarbital in laboratory mice (Mus musculus). JAALAS 58(3), 373-379.

Clinical, physiologic, and behavioral evaluation of permanently catheterized NMRI mice

Vascular catheterization is becoming a popular technique in laboratory rodents, facilitating repetitive blood sampling and infusion in individual animals. In mice, catheterization is complicated by their small body size, which may increase the risk of postoperative complications that may both...

Year Published: 2019Topics: Cannulation, Catheterization, & IntubationAnimal Type: Mouse, Rodent

Citation: Falkenberg, M. K., Teilmann, A. C., Henriksen, T. et al. 2019. Clinical, physiologic, and behavioral evaluation of permanently catheterized NMRI mice. JAALAS 58(3), 380-389.

Compassion fatigue, euthanasia stress, and their management in laboratory animal research

This review is designed to assist both individuals and organizations involved in animal-based research to understand and appreciate the importance and potential risks of compassion fatigue and euthanasia stress. We reviewed current literature regarding compassion fatigue and euthanasia stress as...

Year Published: 2019Topics: Human-Animal InteractionAnimal Type: All/General

Citation: Newsome, J. T., Clemmons, E. A., Fitzhugh, D. C. et al. 2019. Compassion fatigue, euthanasia stress, and their management in laboratory animal research. JAALAS 58(3), 289-292.

Human infant pants for postoperative protection during social housing of New Zealand white rabbits (Oryctolagus cuniculus)

Elizabethan collars (E-collars) are commonly used in various species to safeguard healing wounds. However, E-collars inadvertently restrict the expression of normal species-typical behaviors, including coprophagy, self-grooming, and social housing. To maintain social housing in accordance with recommendations in the 8th...

Year Published: 2019Topics: Disease/Experimental Model, Social Housing & CompanionshipAnimal Type: Rabbit

Citation: Bartley, K. A., Johnson, C. H. 2019. Human infant pants for postoperative protection during social housing of New Zealand white rabbits (Oryctolagus cuniculus). JAALAS 58(4), 510-516.

The role of emotional contagion in the distress exhibited by grouped mice exposed to CO2

The 2013 AVMA Guidelines for the Euthanasia of Animals recommends a chamber volume displacement rate of 10% to 30% per minute (v/min) when euthanizing small laboratory rodents with CO2. Group euthanasia of mice is a common practice, and grouping strangers...

Year Published: 2019Topics: EuthanasiaAnimal Type: Mouse, Rodent

Citation: Moffitt, A. D., Brignolo, L. L., Ardeshir, A. et al. 2019. The role of emotional contagion in the distress exhibited by grouped mice exposed to CO2. JAALAS 58(4), 430-437.