Rodent

A surgical recovery matrix to evaluate post-surgical recovery in mice using sham and myocardial infarction models of cardiac surgery as prototypes (2025)

Examinations of biomarkers are useful in measuring overall health. Endpoints are critical to assess the threshold where the scientific aim of the study does not prevail over the wellbeing of experimental laboratory animal. However, parameters able to assess health and...

Year Published: 2025Topics: Surgery & Post-Op, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Pal, E., Shokoples, B., Naik, S. et al. 2025. A surgical recovery matrix to evaluate post-surgical recovery in mice using sham and myocardial infarction models of cardiac surgery as prototypes. PLOS ONE 20(5), e0323317.

Refining intratracheal administration (2024)

Intratracheal administration is one of the primary methods for introducing substances into the lungs of experimental mice. In order for all lobes of the lungs to be targeted intubation under anesthesia is the ideal method. This procedure has been amended...

Year Published: 2024Topics: Cannulation, Catheterization, & IntubationAnimal Type: Mouse, Rodent

Citation: O'Brien, J., Easter, H. 2024. Refining intratracheal administration. Animal Technology and Welfare 23(3), 222–224.

The development and use of a cage-topper to enhance rat welfare (2025)

The welfare of rats used in scientific research is an important concern. Recent studies show that larger, more complex housing improves rat welfare compared to standard conventional cages. However there are typically both practical and financial constraints to implementing this....

Year Published: 2025Topics: Environmental Enrichment, HousingAnimal Type: Rat, Rodent

Citation: Neville, V., Phelon, L., Handley, C. et al. 2025. The development and use of a cage-topper to enhance rat welfare. Animal Technology and Welfare 24(1), 35–38.

Contactless body temperature assessment for signalling humane endpoints in a mouse model of sepsis

Minimising suffering is an ethical and legal requirement in animal research. This is particularly relevant for research on animal models of sepsis and septic shock, which show rapid progression towards severe stages and death. Specific and reliable criteria signalling non-recovery...

Year Published: 2025Topics: Disease/Experimental Model, Humane EndpointAnimal Type: Mouse, Rodent

Citation: Miranda, C., Oliveira, L., Carmo, A. M. et al. 2025. Contactless body temperature assessment for signalling humane endpoints in a mouse model of sepsis. Animal Welfare 34, e13.

Does the regular husbandry handling method affect response to a novel handler (2024)

Aims: Aim 1: Investigate the effects of tube vs tail handing on ease of handling of mice by future experimenters. Aim 2: Investigate the effects of tube vs tail handling on anxiety in mice. Aim 3: Investigate where there are...

Year Published: 2024Topics: HandlingAnimal Type: Mouse, Rodent

Citation: McLaughlin, T., Langston, R., Dennison, N. 2024. Does the regular husbandry handling method affect response to a novel handler. Animal Technology and Welfare 23(3), 215–216.

Implementing refinement in the EAE mouse model (2025)

Experimental autoimmune encephalomyelitis (EAE) is a model used in rodents to induce inflammation in the central nervous system. It is commonly used as a model for human multiple sclerosis (MS) and other diseases that involve demyelination. EAE has the potential...

Year Published: 2025Topics: Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Kuncova, S. 2025. Implementing refinement in the EAE mouse model. Animal Technology and Welfare 24(1), 57–61.

Analgesia administration practices to support minimal handling (2024)

An adequate analgesic strategy is important to improve the postoperative recovery and welfare of laboratoy animals. It is desirable that the method for administering the drug is non-invasive and stress-free. Below are a few methods that we use to minimise...

Year Published: 2024Topics: Analgesia, Drug/Substance Administration, Surgery & Post-OpAnimal Type: Mouse, Rodent

Citation: Keenan, R., Lynch, A., Murphy, S. et al. 2024. Analgesia administration practices to support minimal handling. Animal Technology and Welfare 23(3), 239–240.

Juvenile male rats form preferences based on strain when playing in groups but not in pairs (2025)

Like many young mammals, juvenile rats engage in rough-and-tumble play. Play occurs naturally both in wild and laboratory rats, making it a suitable, ethologically relevant behavior to investigate. In the laboratory, rats are typically housed and tested in dyads, despite...

Year Published: 2025Topics: Natural BehaviorAnimal Type: Rat, Rodent

Citation: Ham, J. R., Jaiswal, D., Waner-Mariquito, R. et al. 2025. Juvenile male rats form preferences based on strain when playing in groups but not in pairs. Frontiers in Behavioral Neuroscience 19.

Physiological effects of environmental enrichment on BALB/c and C57BL/6 strain mice (2025)

Our aim was to assess the effects of enriched environment (EE) on some physiological variables, comparing BALB/c and C57BL/6 strain mice. Female BALB/c and C57BL/6 were individually housed under standard laboratory cages for 6 weeks and randomly separated into groups (n = 7...

Year Published: 2025Topics: Environmental Enrichment, Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Gama, L. A., Almeida, M. A. S. O., de Souza Souto, P. C. et al. 2025. Physiological effects of environmental enrichment on BALB/c and C57BL/6 strain mice. Discover Animals 2(1), 7.

What are the most prevalent welfare issues for pet small mammals? (2025)

The welfare of pet small mammals is an understudied, but growing research topic in the UK and Europe. We surveyed European veterinary experts who each rated severity and prevalence of a large number of issues in the eight most common...

Year Published: 2025Topics: Abnormal/Problematic Behavior, Handling, HousingAnimal Type: Guinea Pig, Hamster, Mouse, Other Rodent, Rabbit, Rodent

Citation: Fenton, L., Benato, L., Mancinelli, E. et al. 2025. What are the most prevalent welfare issues for pet small mammals? Animals 15(10), 1423.