Rodent

Refinement of intraperitoneal injection of sodium pentobarbital for euthanasia in laboratory rats (Rattus norvegicus)

Background: The Canadian Council on Animal Care and American Veterinary Medical Association classify intraperitoneal (IP) pentobarbital as an acceptable euthanasia method in rats. However, national guidelines do not exist for a recommended dose or volume and IP euthanasia has been...

Year Published: 2016Topics: EuthanasiaAnimal Type: Rat, Rodent

Citation: Zatroch, K. K., Knight, C. G., Reime, J. N. et al. 2017. Refinement of intraperitoneal injection of sodium pentobarbital for euthanasia in laboratory rats (Rattus norvegicus). BMC Veterinary Research 13, 60.

Refinement of analgesia following thoracotomy and experimental myocardial infarction using the Mouse Grimace Scale

What is the central question of this study? There is an ethical imperative to optimize analgesia protocols for laboratory animals, but this is impeded by our inability to recognize pain reliably. We examined whether the Mouse Grimace Scale (MGS) provides...

Year Published: 2015Topics: Disease/Experimental Model, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Faller, K. M., McAndrew, D. J., Schneider, J. E. et al. 2015. Refinement of analgesia following thoracotomy and experimental myocardial infarction using the Mouse Grimace Scale. Experimental Physiology 100(2), 164-172.

The effect of gentle handling on depressive-like behavior in adult male mice: Considerations for human and rodent interactions in the laboratory

Environmental factors play a significant role in well-being of laboratory animals. Regulations and guidelines recommend, if not require, that stressors such as bright lighting, smells, and noises are eliminated or reduced to maximize animal well-being. A factor that is often...

Year Published: 2018Topics: Handling, Human-Animal InteractionAnimal Type: Mouse, Rodent

Citation: Neely, C., Lane, C., Torres, J. et al. 2018. The effect of gentle handling on depressive-like behavior in adult male mice: Considerations for human and rodent interactions in the laboratory. Behavioural Neurology 2018, 2976014.

Behavioural syndromes in stereotypic striped mice

Stereotypical behaviours (SBs) are abnormal, repetitive behaviours often observed in captivity. SBs are linked to impoverished captive conditions, and stereotypic individuals show a particular set of behaviours (e.g. bolder personality, greater activity) indicating proactive coping. Yet, we do not know...

Year Published: 2019Topics: Abnormal/Problematic BehaviorAnimal Type: Mouse, Rodent

Citation: Silber, S., Joshi, S., Pillay, N. 2019. Behavioural syndromes in stereotypic striped mice. Applied Animal Behaviour Science 212, 74-81.

Ethanol and a chemical from fox faeces modulate exploratory behaviour in laboratory mice

Mice are macrosmatic animals that use olfaction as their main source of information to increase fitness; they process predator cues to assess risk, and plants and fruit cues to find nutritional resources and assess their quality or toxicity. In this...

Year Published: 2019Topics: Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Grau, C., Leclercq, J., Descout, E. et al. 2019. Ethanol and a chemical from fox faeces modulate exploratory behaviour in laboratory mice. Applied Animal Behaviour Science 213, 117-123.

Can live with ‘em, can live without ‘em: Pair housed male C57BL/6J mice show low aggression and increasing sociopositive interactions with age, but can adapt to single housing if separated

The basic question as to whether male laboratory mice should be singly or group housed represents a major animal welfare concern within current laboratory animal legislation and husbandry. To better understand the behavioural and physiological mechanisms underlying this issue, we...

Year Published: 2019Topics: Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Melotti, L., Kästner, N., Eick, A. K. et al. 2019. Can live with ‘em, can live without ‘em: Pair housed male C57BL/6J mice show low aggression and increasing sociopositive interactions with age, but can adapt to single housing if separated. Applied Animal Behaviour Science 214, 79-88.

Lighting environment: What colour of light do male C57BL/6J prefer?

Environmental factors applied in animal research facilities need to be regulated accurately not only for the welfare of laboratory animals but also for the reliability of the experimental results. However, the effect of lighting environment and its characteristics on animals...

Year Published: 2018Topics: Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Paronis, E., Kapogiannatou, A., Paschidis, K. et al. 2018. Lighting environment: What colour of light do male C57BL/6J prefer? Applied Animal Behaviour Science 209, 99-103.

Practical rat tickling: Determining an efficient and effective dosage of heterospecific play

Laboratory rats may experience stress during handling which can reduce their welfare. Rat tickling, a handling technique that mimics aspects of rat rough-and-tumble play, has been found to induce positive affect based on production of 50-kHz ultrasonic vocalizations (USVs). However,...

Year Published: 2018Topics: Human-Animal InteractionAnimal Type: Rat, Rodent

Citation: LaFollette, M. R., O'Haire, M. E., Cloutier, S. et al. 2018. Practical rat tickling: Determining an efficient and effective dosage of heterospecific play. Applied Animal Behaviour Science 208, 82-91.

Intergenerational sex-specific transmission of maternal social experience

The social environment is a major determinant of individual stress response and lifetime health. The present study shows that (1) social enrichment has a significant impact on neuroplasticity and behaviour particularly in females; and (2) social enrichment in females can...

Year Published: 2018Topics: Reproduction, Social Housing & CompanionshipAnimal Type: Rat, Rodent

Citation: Faraji, J., Karimi, M., Soltanpour, N. et al. 2018. Intergenerational sex-specific transmission of maternal social experience. Scientific Reports 8, 10529.

Evaluation of analgesic efficacy of meloxicam and 2 formulations of buprenorphine after laparotomy in female Sprague-Dawley rats

Managing postoperative pain in rodents is an important part of any animal care and use program, and identifying an optimal analgesic plan for a surgical procedure is critical to providing for animal welfare. Opioids and NSAID are commonly used in...

Year Published: 2018Topics: AnalgesiaAnimal Type: Rat, Rodent

Citation: Nunamaker, E. A., Goldman, J. L., Adams, C. R. et al. 2018. Evaluation of analgesic efficacy of meloxicam and 2 formulations of buprenorphine after laparotomy in female Sprague-Dawley rats. JAALAS 57(5), 498–507.