Rodent

Standard laboratory housing for mice restricts their ability to segregate space into clean and dirty areas

Laboratory mice (Mus musculus) are typically housed in simple cages consisting of one open space. These standard cages may thwart mouse ability to segregate resting areas from areas where they eliminate, a behaviour that is prevalent across the animal kingdom....

Year Published: 2019Topics: Housing, Natural BehaviorAnimal Type: Mouse, Rodent

Citation: Makowska, I. J., Franks, B., El-Hinn, C. et al. 2019. Standard laboratory housing for mice restricts their ability to segregate space into clean and dirty areas. Scientific Reports 9, 6179.

A sensitive scoring system for the longitudinal clinical evaluation and prediction of lethal disease outcomes in newborn mice

Neonatal animal models are increasingly employed in order to unravel age-specific disease mechanisms. Appropriate tools objectifying the clinical condition of murine neonates are lacking. In this study, we tested a scoring system specifically designed for newborn mice that relies on...

Year Published: 2019Topics: Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Fehlhaber, B., Heinemann, A. S., Rübensam, K. et al. 2019. A sensitive scoring system for the longitudinal clinical evaluation and prediction of lethal disease outcomes in newborn mice. Scientific Reports 9, 5919.

Behavioural response to the environmental changes of various types in Lister-Hooded male rats

The animal preference for complexity is most clearly demonstrated when the environmental change takes the form of an increase in complexity. Therefore, one of the potential difficulties in interpretation is that the preference for perceptual novelty may be confounded with...

Year Published: 2019Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Pisula, W., Modlinska, K., Chrzanowska, A. 2019. Behavioural response to the environmental changes of various types in Lister-Hooded male rats. Scientific Reports 9, 7111.

Evaluating analgesic efficacy and administration route following craniotomy in mice using the grimace scale

Most research laboratories abide by guidelines and mandates set by their research institution regarding the administration of analgesics to control pain during the postoperative period. Unfortunately, measuring pain originating from the head is difficult, making adequate decisions regarding pain control...

Year Published: 2019Topics: Analgesia, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Cho, C., Michalidis, V., Lecker, I. et al. 2019. Evaluating analgesic efficacy and administration route following craniotomy in mice using the grimace scale. Scientific Reports 9, 359.

Opportunities for improving animal welfare in rodent models of epilepsy and seizures

Animal models of epilepsy and seizures, mostly involving mice and rats, are used to understand the pathophysiology of the different forms of epilepsy and their comorbidities, to identify biomarkers, and to discover new antiepileptic drugs and treatments for comorbidities. Such...

Year Published: 2016Topics: Disease/Experimental ModelAnimal Type: Mouse, Rat, Rodent

Citation: Lidster, K., Jefferys, J. G., Blümcke, I. et al. 2016. Opportunities for improving animal welfare in rodent models of epilepsy and seizures. Journal of Neuroscience Methods 260, 2-25.

Carbon dioxide, but not isoflurane, elicits ultrasonic vocalizations in female rats

Gradual filling of a chamber with carbon dioxide is currently listed by the Canadian Council on Animal Care guidelines as a conditionally acceptable method of euthanasia for rats. Behavioural evidence suggests, however, that exposure to carbon dioxide gas is aversive....

Year Published: 2013Topics: EuthanasiaAnimal Type: Rat, Rodent

Citation: Chisholm, J., De Rantere D., Fernandez, N. J. et al. 2013. Carbon dioxide, but not isoflurane, elicits ultrasonic vocalizations in female rats. Laboratory Animals 47(4), 324-7.

Non-invasive 3D time-of-flight imaging technique for tumour volume assessment in subcutaneous models

Subcutaneous tumour xenograft volumes are generally measured using callipers. This method is susceptible to inter- and intra-observer variability and systematic inaccuracies. Non-invasive 3D measurement using ultrasound and magnetic resonance imaging (MRI) have been considered, but require immobilization of the animal....

Year Published: 2015Topics: Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Delgado San Martin, J. A., Worthington, P., Yates, J. W. T. 2015. Non-invasive 3D time-of-flight imaging technique for tumour volume assessment in subcutaneous models. Laboratory Animals 49(2), 168-171.

Standardized environmental enrichment supports enhanced brain plasticity in healthy rats and prevents cognitive impairment in epileptic rats

Environmental enrichment of laboratory animals influences brain plasticity, stimulates neurogenesis, increases neurotrophic factor expression, and protects against the effects of brain insult. However, these positive effects are not constantly observed, probably because standardized procedures of environmental enrichment are lacking. Therefore,...

Year Published: 2013Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Fares, R. P., Belmeguenai, A., Sanchez, P.E. et al. 2013. Standardized environmental enrichment supports enhanced brain plasticity in healthy rats and prevents cognitive impairment in epileptic rats. PLOS ONE 8(1): e53888.

Evaluation of the effects of space allowance on measures of animal welfare in laboratory mice

We studied how space allowance affects measures of animal welfare in mice by systematically varying group size and cage type across three levels each in both males and females of two strains of mice (C57BL/6ByJ and BALB/cByJ; n = 216...

Year Published: 2018Topics: Housing, Social Housing & Companionship, Stocking DensityAnimal Type: Mouse, Rodent

Citation: Bailoo, J. D., Murphy, E., Varholick, J. A. et al. 2018. Evaluation of the effects of space allowance on measures of animal welfare in laboratory mice. Scientific Reports 8, 713.

Effect of light colour temperature and intensity on the behaviour of male C57CL/6J mice

Light is an important environmental factor affecting laboratory animals' well-being but still there is a range of light parameters in animal research facilities that need further study. Behavioural testing was conducted to study the impact of different conditions of light...

Year Published: 2016Topics: Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Kapogiannatou, A., Paronis, E., Paschidis, K. et al. 2016. Effect of light colour temperature and intensity on the behaviour of male C57CL/6J mice. Applied Animal Behaviour Science 184, 135-140.