Rodent

A novel dietary restriction method for group-housed rats: Weight gain and clinical chemistry characterization

Laboratory rodents are usually fed ad libitum. Moderate dietary restriction decreases mortality and morbidity compared with ad libitum feeding. There are, however, problems in achieving dietary restriction. Traditional methods of restricted feeding may interfere with the diurnal rhythms of the...

Year Published: 2009Topics: Environmental Enrichment, Husbandry & ManagementAnimal Type: Rat, Rodent

Citation: Kasanen, I. H. E., Inhilä, K. J., Nevalainen, J. I. et al. 2009. A novel dietary restriction method for group-housed rats: Weight gain and clinical chemistry characterization. Laboratory Animals 43, 138-148.

Refinement as ethics principle in animal research: Is it necessary to standardize the environmental enrichment in laboratory animals?

The Environmental enrichment technique, although scientifically recognized for raising the level of animal welfare, has led to the questioning of its influence on the results of experimental research. Thus, the goal is to promote reflection about the need for standardization...

Year Published: 2021Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Fischer, M. L., Rodrigues, G. S., Aguero, W. P. et al. 2021. Refinement as ethics principle in animal research: Is it necessary to standardize the environmental enrichment in laboratory animals? Anais da Academia Brasileira de Ciências, 93(1), e20191526.

Preclinical validation of the micropipette-guided drug administration (MDA) method in the maternal immune activation model of neurodevelopmental disorders

Pharmacological treatments in laboratory rodents remain a cornerstone of preclinical psychopharmacological research and drug development. There are numerous ways in which acute or chronic pharmacological treatments can be implemented, with each method having certain advantages and drawbacks. Here, we describe...

Year Published: 2020Topics: Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Scarborough, J., Mueller, F., Arban, R. et al. 2020. Preclinical validation of the micropipette-guided drug administration (MDA) method in the maternal immune activation model of neurodevelopmental disorders. Brain, Behavior, and Immunity 88, 461-470.

The development and use of facial grimace scales for pain measurement in animals

The measurement of pain in animals is surprisingly complex, and remains a critical issue in veterinary care and biomedical research. Based on the known utility of pain measurement via facial expression in verbal and especially non-verbal human populations, “grimace scales”...

Year Published: 2020Topics: Welfare AssessmentAnimal Type: Cat, Cattle, Equine, Ferret, Mouse, Pig, Rabbit, Rat, Rodent, Sheep

Citation: Mogil, J. S., Pang, D. S. J., Silva Dutra, G. G. et al. 2020. The development and use of facial grimace scales for pain measurement in animals. Neuroscience & Biobehavioral Reviews 116, 480-496.

Voluntary exercise enhances hippocampal theta rhythm and cognition in the rat

Regular exercise promotes learning and memory functions. Theta activity is known to relate to various cognitive functions. An increase in theta power may be related to higher cognitive functioning and learning functions. However, evidence is lacking to directly confirm that...

Year Published: 2021Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Li, J.-Y., Kuo, T. B. J., Hung, C.-T. et al. 2021. Voluntary exercise enhances hippocampal theta rhythm and cognition in the rat. Behavioural Brain Research 399, 112916.

Where are you from? Female mice raised in enriched or conventional cages differ socially, and can be discriminated by other mice

Laboratory rodents raised in environmentally-enriched (EE) cages differ behaviourally and cognitively from conventionally-housed (CH) animals. We hypothesised that mice can detect such differences, testing this using differentially-raised female C57BL/6 s as subjects, and differentially-raised female BALB/cs and DBA/2 s as...

Year Published: 2021Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Adcock, A., Choleris, E., Denommé, M. et al. 2021. Where are you from? Female mice raised in enriched or conventional cages differ socially, and can be discriminated by other mice. Behavioural Brain Research 400, 113025.

Regular touchscreen training affects faecal corticosterone metabolites and anxiety-like behaviour in mice

Automated touchscreen techniques find increasing application for the assessment of cognitive function in rodents. However, hardly anything is known about the potential impact of touchscreen-based training and testing procedures on the animals under investigation. Addressing this question appears particularly important...

Year Published: 2021Topics: Animal TrainingAnimal Type: Mouse, Rodent

Citation: Krakenberg, V., Wewer,M., Palme, R. et al. 2021. Regular touchscreen training affects faecal corticosterone metabolites and anxiety-like behaviour in mice. Behavioural Brain Research 401, 113080.

DIY: Creating a rat play cage

To provide extra enrichment for our training rats (Sprague Dawley; CRL: SD), our team discussed the idea of developing a rat play cage. Animals are housed in the Comparative Bioscience Center at The Rockefeller University, an AAALAC-accredited facility. All enrichment...

Year Published: 2021Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Monnas, J. 2021. DIY: Creating a rat play cage. Laboratory Animal Science Professional 9(2) (March/April), 46-48.

Loss of environmental enrichment elicits behavioral and physiological dysregulation in female rats

Chronic stress drives behavioral and physiological changes associated with numerous psychiatric disease states. In rodents, the vast majority of chronic stress models involve imposition of external stressors, whereas in humans stress is often driven by internal cues, commonly associated with...

Year Published: 2019Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Morano, R., Hoskins, O., Smith, B. L. et al. 2019. Loss of environmental enrichment elicits behavioral and physiological dysregulation in female rats. Frontiers in Behavioral Neuroscience 12, 287.

Behavioral and physiological consequences of enrichment loss in rats

Significant loss produces the highest degree of stress and compromised well-being in humans. Current rodent models of stress involve the application of physically or psychologically aversive stimuli, but do not address the concept of loss. We developed a rodent model...

Year Published: 2017Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Smith, B. L., Lyons, C. E., Correa, F. G. et al. 2017. Behavioral and physiological consequences of enrichment loss in rats. Psychoneuroendocrinology 77, 37-46.