Rodent

When to wean? A visual guide to Black, White, and Agouti mouse pup growth P14 – P28

Laboratory mouse pups are commonly weaned between postnatal day 21–28. Utilization of an exact wean date postpartum is a concrete metric for mouse colony management, but variation can result such as: developmental differences among genetically modified strains, personnel differences in...

Year Published: 2021Topics: Rearing & WeaningAnimal Type: Mouse, Rodent

Citation: Brogan, E., Kirchain, S. 2021. When to wean? A visual guide to Black, White, and Agouti mouse pup growth P14 – P28. Laboratory Animal Science Professional 9(3) (May/June), 46-48.

Effects of cling film draping material on body temperature of mice during surgery

General anesthesia induces many systemic effects, including thermoregulatory impairment and subsequent perioperative hypothermia. Due to the animals' small size, monitoring and maintaining body temperatures in laboratory rodents during anesthesia is important for successful surgical outcomes and prompt anesthetic recovery. Draping...

Year Published: 2021Topics: Surgery & Post-OpAnimal Type: Mouse, Rodent

Citation: Celeste, N. A., Emmer, K. M., Bidot, W. A. et al. 2021. Effects of cling film draping material on body temperature of mice during surgery. JAALAS 60(2), 195-200.

A validated smartphone-based electrocardiogram reveals severe bradyarrhythmias during immobilizing restraint in mice of both sexes and four strains

Mouse handling and restraint affect behavior, physiology, and animal welfare, yet little information is available on how various mouse restraint methods affect cardiovascular parameters. We validated the use of a smartphone-based ECG sys- tem in mice by performing simultaneous smartphone...

Year Published: 2021Topics: RestraintAnimal Type: Mouse, Rodent

Citation: Labitt, R. N., Oxford, E. M., Davis, A. K. et al. 2021. A validated smartphone-based electrocardiogram reveals severe bradyarrhythmias during immobilizing restraint in mice of both sexes and four strains. JAALAS 60(2), 201-212.

Comparison of two hair removal methods in Sprague–Dawley rats (Rattus norvegicus)

Rats commonly undergo surgery for research purposes. However, the effects of different methods of hair removal on wound healing and surgical site infections (SSI) in rats has not been evaluated. The current study evaluated 2 hair removal methods, clipping with...

Year Published: 2021Topics: Surgery & Post-OpAnimal Type: Rat, Rodent

Citation: Rowley, N. L., Ramos-Rivera, E., Raiciulescu, S. et al. 2021. Comparison of two hair removal methods in Sprague–Dawley rats (Rattus norvegicus). JAALAS 60(2), 213-220.

Effects of daytime blue-enriched LED light on physiologic parameters of three common mouse strains maintained on an IVC system

Light has been a crucial part of everyday life since the beginning of time. Most recently, light-emitting diode (LED) light enriched in the blue-appearing portion of the visible spectrum (465 to 485 nm), which is more efficient in energy use,...

Year Published: 2021Topics: Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Voros, G. B., Dauchy, R. T., Myers, L. et al. 2021. Effects of daytime blue-enriched LED light on physiologic parameters of three common mouse strains maintained on an IVC system. JAALAS 60(3), 259-271.

Effects of oxygen supplementation on injectable and inhalant anesthesia in C57BL/6 mice

Oxygen supplementation is rarely considered when anesthetizing laboratory mice, despite reports that mice become profoundly hypoxic under anesthesia. Little is known about the effects of hypoxia on anesthetic performance. This article focuses on the effects of oxygen supplementation on physiologic...

Year Published: 2021Topics: Anesthesia & SedationAnimal Type: Mouse, Rodent

Citation: Blevins, C. E., Celeste, N. A., Marx, J. O. 2021. Effects of oxygen supplementation on injectable and inhalant anesthesia in C57BL/6 mice. JAALAS 60(3), 289-297.

Effects of analgesics on tumor growth in mouse models of prostate cancer bone metastasis

Murine models of tumor development often require invasive procedures for tumor implantation, potentially causing pain or distress. However, analgesics are often withheld during implantation because of concerns that they may adversely affect tumor development. Previous studies examining the effects of...

Year Published: 2021Topics: Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Xu, J. J., Thurston, S. E., Robinson, T. J. et al. 2021. Effects of analgesics on tumor growth in mouse models of prostate cancer bone metastasis. JAALAS 60(3), 341-348.

Effects of pair housing on patency of jugular catheters in rats (Rattus norvegicus)

Chronic vascular access devices are widely used in a variety of species for repeated blood sampling or substance administration. Jugular catheters are commonly used for studying addiction-related behaviors in rats. Rats with catheters have historically been individually housed for the...

Year Published: 2021Topics: Cannulation, Catheterization, & Intubation, External Bodily Equipment, Social Housing & CompanionshipAnimal Type: Rat, Rodent

Citation: Krueger, L. D., Chang, S. E., Motoc, M. et al. 2021. Effects of pair housing on patency of jugular catheters in rats (Rattus norvegicus). JAALAS 60(3), 357-364.

Provision of food and water in rodent whole body plethysmography safety pharmacology respiratory studies – Impact on animal welfare and data quality

Introduction: We evaluated the feasibility of providing food and water to rodents during whole body plethysmography (WBP) studies as a welfare improvement to standard conditions. Methods: Male Han Wistar rats or CD1 mice (n=8) were placed in WBP chambers and...

Year Published: 2017Topics: Biological Sampling & Physiological MeasurementAnimal Type: Mouse, Rat, Rodent

Citation: Grant, C., Marks, L., Prior, H. 2017. Provision of food and water in rodent whole body plethysmography safety pharmacology respiratory studies – Impact on animal welfare and data quality. Journal of Pharmacological and Toxicological Methods 88(Part 1), 79-84.

Reducing suffering in animal models and procedures involving seizures, convulsions and epilepsy

This report is based on discussions and submissions from an expert working group consisting of veterinarians, animal care staff and scientists with expert knowledge relevant to the field and aims to facilitate the implementation of the Three Rs (replacement, reduction...

Year Published: 2013Topics: Disease/Experimental ModelAnimal Type: Mouse, Rat, Rodent

Citation: Wolfensohn, S., Hawkins, P., Lilley, E. et al. 2013. Reducing suffering in animal models and procedures involving seizures, convulsions and epilepsy. Journal of Pharmacological and Toxicological Methods 67(1), 9-15.