Rodent

Camera-based respiration monitoring of unconstrained rodents

Animal research has always been crucial for various medical and scientific breakthroughs, providing information on disease mechanisms, genetic predisposition to diseases, and pharmacological treatment. However, the use of animals in medical research is a source of great controversy and ongoing...

Year Published: 2023Topics: Biological Sampling & Physiological MeasurementAnimal Type: Rat, Rodent

Citation: Breuer, L., Mösch, L., Kunczik, J. et al. 2023. Camera-based respiration monitoring of unconstrained rodents. Animals 13(12), 1901.

Tetra-primer amplification-refractory mutationsystem (ARMS)—PCR for genotyping mouse leptin gene mutation

Due to spontaneous deficiency in leptin, ob/ob mice are one of the most commonly used experimental animal models in diabetes research. In this study, we reported a quick and easy-to-conduct genotyping method using tetra-primer amplification refractory mutation system-polymerase chain reaction...

Year Published: 2022Topics: Disease/Experimental Model, Identification MethodAnimal Type: Mouse, Rodent

Citation: Chen, J., Xu, X., Dalhaimer, P. et al. 2022. Tetra-primer amplification-refractory mutationsystem (ARMS)—PCR for genotyping mouse leptin gene mutation. Animals 12(19), 2680.

Impact of partial bile duct ligation with or without repeated magnetic resonance imaging examinations in mice

Partial bile duct ligation (pBDL) is considered a well-tolerated cholestatic model. Magnetic resonance imaging (MRI) is one of the most widely used tools in noninvasive imaging. However, no systematic studies have reported the possible effects of repeated MRI assessments in...

Year Published: 2022Topics: Disease/Experimental Model, Imaging & Electrophysiological RecordingAnimal Type: Mouse, Rodent

Citation: Chen, T., Zhou, Z.-Y., Liu, J.-Y. et al. 2022. Impact of partial bile duct ligation with or without repeated magnetic resonance imaging examinations in mice. Scientific Reports 12(1), 21014.

Rat’s response to a novelty and increased complexity of the environment resulting from the introduction of movable vs

Most animals, including rats, show a preference for more complex environments. This is demonstrated particularly well when complexity increases due to the addition of new elements to the environment. The aim of the study was to investigate the reaction to...

Year Published: 2022Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Chrzanowska, A., Modlinska, K., Goncikowska, K. et al. 2022. Rat's response to a novelty and increased complexity of the environment resulting from the introduction of movable vs. stationary objects in the free exploration test. PLOS ONE 17(12), e0279006.

Animal welfare considerations when conducting OECD test guideline inhalation and toxicokinetic studies for nanomaterials

The OECD test guidelines for animal experiments play an important role in evaluating the chemical hazards. Animal tests performed using OECD guidelines, especially when the good laboratory practice (GLP) principle is applied, reduce the duplication of toxicity testing and ensure...

Year Published: 2022Topics: Disease/Experimental ModelAnimal Type: All/General, Rat, Rodent

Citation: Chung, Y. H., Gulumian, M., Pleus, R. C. et al. 2022. Animal welfare considerations when conducting OECD test guideline inhalation and toxicokinetic studies for nanomaterials. Animals 12(23), 3305.

Review of rat (Rattus norvegicus), Mouse (Mus musculus), Guinea pig (Cavia procellus), and rabbit (Oryctolagus cuniculus) indicators for welfare assessment

The monitoring and assessment of animals is important for their health and welfare. The appropriate selection of multiple, validated, and feasible welfare assessment indicators is required to effectively identify compromises or improvements to animal welfare. Animal welfare indicators can be...

Year Published: 2023Topics: Welfare AssessmentAnimal Type: Guinea Pig, Mouse, Rabbit, Rat, Rodent

Citation: Cohen, S., Ho, C. 2023. Review of rat (Rattus norvegicus), Mouse (Mus musculus), Guinea pig (Cavia procellus), and rabbit (Oryctolagus cuniculus) indicators for welfare assessment. Animals 13(13), 2167.

3D-printed lightweight dorsal skin fold chambers from PEEK reduce chamber-related animal distress

The dorsal skinfold chamber is one of the most important in vivo models for repetitive longitudinal assessment of microcirculation and inflammation. This study aimed to refine this model by introducing a new lightweight chamber made from polyetheretherketone (PEEK). Body weight,...

Year Published: 2022Topics: External Bodily EquipmentAnimal Type: Mouse, Rodent

Citation: Xie, W., Lorenz, M., Poosch, F. et al. 2022. 3D-printed lightweight dorsal skin fold chambers from PEEK reduce chamber-related animal distress. Scientific Reports 12(1), 11599.

Sex differences in 50 kHz call subtypes emitted during tickling-induced playful behaviour in rats

‘Tickling' induces positive affective states in laboratory rats as evidenced by the production of 50-kHz ultrasonic vocalisations (USVs), although this has mostly been investigated in males. Juvenile rats emit distinctive 50-kHz USV subtypes. Frequency-modulated (FM) 50-kHz USVs are thought to...

Year Published: 2022Topics: VocalizationAnimal Type: Rat, Rodent

Citation: Tivey, E. K. L., Martin, J. E., Brown, S. M. et al. 2022. Sex differences in 50 kHz call subtypes emitted during tickling-induced playful behaviour in rats. Scientific Reports 12(1), 15323.

The prevention of home-cage grid climbing affects muscle strength in mice

Experimenters and treatment methods are the major contributors to data variability in behavioral neuroscience. However, home cage characteristics are likely associated with data variability. Mice housed in breeding cages spontaneously exhibit behavioral patterns such as biting into the wire grid...

Year Published: 2022Topics: HousingAnimal Type: Mouse, Rodent

Citation: Ueno, H., Takahashi, Y., Murakami, S. et al. 2022. The prevention of home-cage grid climbing affects muscle strength in mice. Scientific Reports 12(1), 15263.

Post mortem study on the effects of routine handling and manipulation of laboratory mice

Routine handling and manipulation of laboratory mice are integral components of most preclinical studies. Any type of handling and manipulation may cause stress and result in physical harm to mice, potentially leading to unintended consequences of experimental outcomes. Nevertheless, the...

Year Published: 2022Topics: HandlingAnimal Type: Mouse, Rodent

Citation: Assenmacher, C.-A., Lanza, M., Tarrant, J. C. et al. 2022. Post mortem study on the effects of routine handling and manipulation of laboratory mice. Animals 12(23), 3234.