Rodent

The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals (9th ed.)

The latest edition of the seminal reference on the care and management of laboratory and research animals. The newly revised ninth edition of The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals delivers an up-to-date...

Year Published: 2024Topics: Animal Training, Environmental Enrichment, Euthanasia, Housing, Husbandry & Management, Natural Behavior, Relocation & Transport, Welfare AssessmentAnimal Type: Amphibian, Bird, Capuchin, Cat, Cattle, Cephalopod, Crustacean, Dog, Equine, Ferret, Finch, Fish, Fowl, Frog & Toad, Gerbil, Goat, Guinea Pig, Hamster, Invertebrate, Lizard, Macaque, Marmoset, Mole Rat, Mouse, Nonhuman Primate, Other Animal, Other Bird, Other Fish, Other Nonhuman Primate, Other Rodent, Pig, Rabbit, Rat, Reptile, Rodent, Sheep, Snake, Tree Shrew, Turtle & Tortoise, Vervet (African Green Monkey), Zebrafish

Citation: Golledge, H., Richardson, C. (Eds.) 2024. The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals (9th ed.). Wiley-Blackwell. 1040 p.

Why all healthy laboratory animals should be rehomed, no matter how small

This paper explores the ethical imperative of rehoming all healthy animals of sentient species after experiments have finished or when they have become otherwise redundant. We take into account disparate perspectives in animal ethics and see how they point in...

Year Published: 2023Topics: Regulations & Ethical ReviewAnimal Type: All/General, Mouse, Rat, Rodent

Citation: Van Loo, P. L. P., Janssens, M. R. E. 2023. Why all healthy laboratory animals should be rehomed, no matter how small. Animals 13(17), 2727.

More exploratory house mice judge an ambiguous situation more negatively

Exploration tendency, one of the most investigated animal personality traits, may be driven by either positive (when seeking interesting information) or negative (to reduce the uncertainty of the environment) affective/emotional profiles. To disentangle the valence of the affective state associated...

Year Published: 2021Topics: Emotion, Pain, & Sentience, PersonalityAnimal Type: Mouse, Rodent

Citation: Verjat, A., Devienne, P., Rödel, H. G. et al. 2021. More exploratory house mice judge an ambiguous situation more negatively. Animal Cognition 24(1), 53–64.

Mice prone to tinnitus after acoustic trauma show increased pre-exposure sensitivity to background noise

Noise-induced tinnitus is generally associated with hearing impairment caused by traumatic acoustic overexposure. Previous studies in laboratory animals and human subjects, however, have observed differences in tinnitus susceptibility, even among individuals with similar hearing loss. The mechanisms underlying increased sensitivity...

Year Published: 2023Topics: Behavioral & Cognitive TestingAnimal Type: Mouse, Rodent

Citation: Rybalko, N., Suchánková, Š., Bureš, Z. et al. 2023. Mice prone to tinnitus after acoustic trauma show increased pre-exposure sensitivity to background noise. Frontiers in Behavioral Neuroscience 17.

A mild stressor induces short-term anxiety and long-term phenotypic changes in trauma-related behavior in female rats

Introduction: Anxiety and anxiety-influenced disorders are sexually dimorphic with women being disproportionately affected compared to men. Given the increased prevalence in women and the documented differences in anxiety and trauma behavior between male and female rats this paper sought to...

Year Published: 2023Topics: Abnormal/Problematic Behavior, Husbandry & ManagementAnimal Type: Rat, Rodent

Citation: Shanazz, K., Nalloor, R., Vazdarjanova, A. 2023. A mild stressor induces short-term anxiety and long-term phenotypic changes in trauma-related behavior in female rats. Frontiers in Behavioral Neuroscience 17.

Ethorobotic rats for rodent behavioral research: Design considerations

Year Published: 2023Topics: Behavioral & Cognitive TestingAnimal Type: Rat, Rodent

Citation: Siddall, R. 2023. Ethorobotic rats for rodent behavioral research: Design considerations. Frontiers in Behavioral Neuroscience 17.

Refinement of the motorised laminectomy-assisted rat spinal cord injury model by analgesic treatment

Usage and reporting of analgesia in animal models of spinal cord injury (SCI) have been sparse and requires proper attention. The majority of experimental SCI research uses rats as an animal model. This study aimed to probe into the effects...

Year Published: 2024Topics: Disease/Experimental ModelAnimal Type: Rat, Rodent

Citation: Sreelatha, H. V., Palekkodan, H., Fasaludeen, A. et al. 2024. Refinement of the motorised laminectomy-assisted rat spinal cord injury model by analgesic treatment. PLOS ONE 19(1), e0294720.

Report of the 2022 RSPCA/UFAW Rodent Welfare Group Meeting

The RSPCA/UFAW Rodent Welfare Group has held a one-day meeting every autumn for the last 29 years, so that its members can discuss current welfare research, exchange views on welfare issues and share experiences of the implementation of the 3Rs...

Year Published: 2023Topics: Emotion, Pain, & Sentience, Environmental Enrichment, Euthanasia, HandlingAnimal Type: Mouse, Other Rodent, Rat, Rodent

Citation: Stevens, C., Hammonds, T., Hinchcliffe, J. et al. 2023. Report of the 2022 RSPCA/UFAW Rodent Welfare Group Meeting. Animal Technology and Welfare 22(2), 91–100.

Rehoming and other refinements and replacement in procedures using golden hamsters in SARS-CoV-2 vaccine research

Effective vaccines are needed to fight the COVID-19 pandemic. Forty golden hamsters were inoculated with two promising vaccine candidates and eighteen animals were used in pilot trials with viral challenge. ELISA assays were performed to determine endpoint serum titres for...

Year Published: 2023Topics: Disease/Experimental ModelAnimal Type: Hamster, Rodent

Citation: Štrbenc, M., Kuhar, U., Lainšček, D. et al. 2023. Rehoming and other refinements and replacement in procedures using golden hamsters in SARS-CoV-2 vaccine research. Animals 13(16), 2616.

Classification of multiple emotional states from facial expressions in head-fixed mice using a deep learning-based image analysis

Facial expressions are widely recognized as universal indicators of underlying internal states in most species of animals, thereby presenting as a non-invasive measure for assessing physical and mental conditions. Despite the advancement of artificial intelligence-assisted tools for automated analysis of...

Year Published: 2023Topics: Emotion, Pain, & Sentience, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Tanaka, Y., Nakata, T., Hibino, H. et al. 2023. Classification of multiple emotional states from facial expressions in head-fixed mice using a deep learning-based image analysis. PLOS ONE 18(7), e0288930.