Rodent

Determining the preferred liquid reward in adult C57BL/6 mice

Using food rewards to motivate mice is commonplace in behavioural research. Using a reward which is highly desirable is of benefit, as it can reduce the need to food restrict animals and can encourage higher levels of consumption, allowing for...

Year Published: 2023Topics: Behavioral & Cognitive Testing, Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Miller, A. L., Leach, M. C. 2023. Determining the preferred liquid reward in adult C57BL/6 mice. Laboratory Animals 57(3), 332–335.

A minimally invasive bronchoscopic approach for direct delivery to murine airways and application to models of pulmonary infection

The laboratory mouse is used extensively for human disease modeling and preclinical therapeutic testing for efficacy, biodistribution, and toxicity. The variety of murine models available, and the ability to create new ones, eclipses all other species, but the size of...

Year Published: 2023Topics: Cannulation, Catheterization, & Intubation, Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Schelde, K., Rosenjack, J., Sonneborn, C. et al. 2023. A minimally invasive bronchoscopic approach for direct delivery to murine airways and application to models of pulmonary infection. Laboratory Animals 57(6), 611–622.

Evaluation of the effect of tramadol, paracetamol and metamizole on the severity of experimental colitis

Application of dextran sodium sulfate (DSS) is often used to induce experimental colitis. Current state of the art is to refrain from the use of analgesics due to their possible interaction with the model. However, the use of analgesics would...

Year Published: 2023Topics: Analgesia, Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Spalinger, M., Schwarzfischer, M., Niechcial, A. et al. 2023. Evaluation of the effect of tramadol, paracetamol and metamizole on the severity of experimental colitis. Laboratory Animals 57(5), 529–540.

Changes in the behavior and body weight of mature, adult male Wistar Han rats after reduced social grouping and social isolation

Changes in housing density, including individual housing, are commonly necessary in animal research. Obtaining reproducibility and translational validity in biomedical research requires an understanding of how animals adapt to changes in housing density. Existing literature mainly addresses acclimatization after transportation....

Year Published: 2022Topics: Social Housing & CompanionshipAnimal Type: Rat, Rodent

Citation: Potrebić, M. S., Pavković, Ž. Z., Srbovan, M. M. et al. 2022. Changes in the behavior and body weight of mature, adult male Wistar Han rats after reduced social grouping and social isolation. JAALAS 61(6), 615–623.

Effects of depilatory cream formulation and contact time on mouse skin

Depilatory creams are widely used in research to remove hair in preparation for surgery, imaging, and other procedures. However, few studies have evaluated the effects of these creams on mouse skin. We sought to determine the cutaneous effects of 2...

Year Published: 2023Topics: Surgery & Post-OpAnimal Type: Mouse, Rodent

Citation: Reichert, M. N., Koewler, N. J., Hargis, A. M. et al. 2023. Effects of depilatory cream formulation and contact time on mouse skin. JAALAS 62(2), 153–162.

Use of a low-calorie flavored gel to facilitate oral self-administration of analgesics in mice

The goals of this study were to determine whether mice would adapt to a low-calorie flavored water gel as their sole source of hydration and whether the addition of acetaminophen, tramadol, meloxicam, or buprenorphine to the gel would affect their...

Year Published: 2023Topics: Analgesia, Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Riddell, D. L., Hyndman, T. H., Bowden, R. S. et al. 2023. Use of a low-calorie flavored gel to facilitate oral self-administration of analgesics in mice. JAALAS 62(2), 163–169.

Effects of different grades of carbon dioxide on euthanasia of mice (Mus musculus)

Carbon dioxide (CO2) is a conditionally acceptable method for mouse euthanasia, according to the American Veterinary Medical Association Guidelines for the Euthanasia of Animals. In a 2012 Office of Laboratory Animal Welfare (OLAW) webinar, representatives of OLAW, the USDA and...

Year Published: 2023Topics: EuthanasiaAnimal Type: Mouse, Rodent

Citation: Stuckey, J. E., Makhija, S. D., Reimer, D. C. et al. 2023. Effects of different grades of carbon dioxide on euthanasia of mice (Mus musculus). JAALAS 62(5), 430–437.

Comparison of systemic extended-release buprenorphine and local extended-release bupivacaine-meloxicam as analgesics for laparotomy in mice

Extended-release (ER) local anesthetics can be used in multi-modal analgesia or in situations in which systemic analgesics may alter animal physiology and thus introduce interpretational confounds. In this study, we compared the analgesic efficacy of an ER buprenorphine formulation with...

Year Published: 2023Topics: Analgesia, Surgery & Post-OpAnimal Type: Mouse, Rodent

Citation: Yang, P., Hish, G., Lester, P. A. 2023. Comparison of systemic extended-release buprenorphine and local extended-release bupivacaine-meloxicam as analgesics for laparotomy in mice. JAALAS 62(5), 416–422.

Evaluation of cage mate–induced postsurgical trauma in mice

Although mice are social animals, individual housing is sometimes requested after surgery. We questioned whether pair-housing mice after surgery resulted in greater trauma to the surgical site as compared with single housing. We further evaluated the effect of individual housing...

Year Published: 2023Topics: Social Housing & Companionship, Surgery & Post-OpAnimal Type: Mouse, Rodent

Citation: Tirado-Muñiz, N., Spangler, T. L., Van Rooyen, H. et al. 2023. Evaluation of cage mate–induced postsurgical trauma in mice. JAALAS 62(2), 170–178.

The effects of enrichment on an abnormal behaviour in naked mole rats (Heterocephalus glaber) at Tilgate Nature Centre

The naked mole rat (Heterocephalus glaber) is a relatively rare mammal in zoological collections with only nine zoos in the United Kingdom holding colonies of varying sizes at the time of study. This study aims to determine whether housing the...

Year Published: 2022Topics: Abnormal/Problematic Behavior, HousingAnimal Type: Mole Rat, Rodent

Citation: Hatcher, N. 2022. The effects of enrichment on an abnormal behaviour in naked mole rats (Heterocephalus glaber) at Tilgate Nature Centre. RATEL (Journal of the Association of British and Irish Wild Animal Keepers) 49(4), 15-18.