Rodent

Enrichment with wood blocks does not affect toxicity assessment in an exploratory toxicology model using Sprague-Dawley rats

Environmental enrichment in rodents may improve animal well-being but can affect neurologic development, immune system function, and aging. We tested the hypothesis that wood block enrichment affects the interpretation of traditional and transcriptomic endpoints in an exploratory toxicology testing model...

Year Published: 2014Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Ditewig, A. C., Bratcher, N. A., Davila, D. R. et al. 2014. Enrichment with wood blocks does not affect toxicity assessment in an exploratory toxicology model using Sprague-Dawley rats. JAALAS 53(3), 246-260.

The social buffering effect of playful handling on responses to repeated intraperitoneal injections in laboratory rats

Handling small animals for veterinary and experimental procedures can negatively affect animal wellbeing. We hypothesized that playful handling (tickling) would decrease stress associated with repeated injections in adult laboratory rats, especially those with prior tickling experience. We compared responses of...

Year Published: 2014Topics: Biological Sampling & Physiological MeasurementAnimal Type: Rat, Rodent

Citation: Cloutier, S., Wahl, K., Baker, C. et al. 2014. The social buffering effect of playful handling on responses to repeated intraperitoneal injections in laboratory rats. JAALAS 53(2), 168-173.

Shedding ultraviolet light on welfare in laboratory rodents: Suggestions for further research and refinement

The welfare of laboratory rats and mice is sought to be optimised through adjustment of a variety of environmental factors, including light intensity and photoperiodicity. However, the fact that rodents are able to perceive ultraviolet (UV) light tends to be...

Year Published: 2014Topics: Husbandry & ManagementAnimal Type: Mouse, Rat, Rodent

Citation: Sorensen, D. B. 2014. Shedding ultraviolet light on welfare in laboratory rodents: Suggestions for further research and refinement. Animal Welfare 23(3), 259-261.

Current understanding and use of environmental enrichment in China

In practice, consideration is given to providing most of the species used in research,testing and education withsome level of environmental enrichment. However, although the current level of awareness and understanding about the benefits of environmental enrichment appears similar across different...

Year Published: 2014Topics: Environmental EnrichmentAnimal Type: All/General, Baboon, Capuchin, Chimpanzee, Dog, Guinea Pig, Hamster, Lemur, Macaque, Marmoset, Mouse, Nonhuman Primate, Other Nonhuman Primate, Owl Monkey, Pig, Rabbit, Rat, Rodent, Squirrel Monkey, Vervet (African Green Monkey)

Citation: Qi, K., De-mi, S., Chuan, Q. 2014. Current understanding and use of environmental enrichment in China. Enrichment Record 20, 8-11.

Use of spontaneous behaviour measures to assess pain in laboratory rats and mice: How are we progressing?

The understanding and recognition of pain in laboratory rats and mice has advanced considerably in recent times. However, there is evidence that despite these advances, analgesics are still relatively underutilised in these species. One possible contributing influence to this is...

Year Published: 2014Topics: Welfare AssessmentAnimal Type: Mouse, Rat, Rodent

Citation: Whittaker, A. L., Howarth, G. S. 2014. Use of spontaneous behaviour measures to assess pain in laboratory rats and mice: How are we progressing? Applied Animal Behaviour Science 151, 1-12.

A comparison of soiled bedding densities and stress in sentinel mice

Sentinel animals are used to monitor the health status of rodents used in research. It is important to screen for potentially pathogenic viruses, parasites, and bacterial organisms to detect and rapidly respond to unwanted pathogens that may adversely affect research...

Year Published: 2014Topics: Housing, Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Murphy, S., Fortner, J., Adusumilli, S. 2014. A comparison of soiled bedding densities and stress in sentinel mice. American Association for Laboratory Animal Science [AALAS] Meeting Official Program, 609. (Abstract #P225).

Effects of breeding configuration on behavior, reproduction, and pathology in the laboratory mouse (Mus musculus)

While numerous published studies have evaluated the effect of housing density on the wellbeing of laboratory mice, little is known on the effect of breeding configuration. The eighth edition of the Guide for the Care and Use of Laboratory Animals...

Year Published: 2014Topics: ReproductionAnimal Type: Mouse, Rodent

Citation: Braden, G.C., Rasmussen, S., Tolwani, R.J. 2014. Effects of breeding configuration on behavior, reproduction, and pathology in the laboratory mouse (Mus musculus). American Association for Laboratory Animal Science [AALAS] Meeting Official Program, 605. (Abstract #P210).

Refining blood collection techniques to improve animal welfare and sample quality

An effort to refine rodent blood collection techniques resulted in an examination of alternative methodologies to improve animal welfare and sample quality. Disease model or repeated sample collection resulted in inadequate sample volume, occasional hemolysis, and complications including bruising, scarring,...

Year Published: 2014Topics: Biological Sampling & Physiological MeasurementAnimal Type: Mouse, Rodent

Citation: Allaire. A. C., Boule, S. 2014. Refining blood collection techniques to improve animal welfare and sample quality. American Association for Laboratory Animal Science [AALAS] Meeting Official Program, 605-606. (Abstract #P212).

Refinement and efficiency through serial microsampling: Cost:benefit analysis

Advances in bioanalytic methods allow for accurate plasma drug level measurement in small sample volumes. Decreased sample volumes enable serial blood sample collection from one rodent, rather than terminal or sparse sampling from multiple rodents. Decreased variability in data from...

Year Published: 2014Topics: Biological Sampling & Physiological MeasurementAnimal Type: Mouse, Rodent

Citation: Bratcher, N. A., Ebert, P. A., Buck, W. et al. 2014. Refinement and efficiency through serial microsampling: Cost:benefit analysis. American Association for Laboratory Animal Science [AALAS] Meeting Official Program, 580. (Abstract #P121).

An innovative restraint device for the placement of intravenous tail vein catheters in anesthetized mice

Consistently accurate intravenous tail vein administration of radiopharmaceuticals in anesthetized mice is a critical component of successful PET/CT imaging in the preclinical setting. Injectable anesthetics are often not suitable for PET imaging and commercially available mouse restraint devices do not...

Year Published: 2014Topics: Biological Sampling & Physiological Measurement, RestraintAnimal Type: Mouse, Rodent

Citation: Tupper, T., Manning, H., Turner, D. et al. 2014. An innovative restraint device for the placement of intravenous tail vein catheters in anesthetized mice. American Association for Laboratory Animal Science [AALAS] Meeting Official Program, 584. (Abstract #P136).