Rodent

Elevating the welfare of mouse dams: A pilot study on elevated tunnels for breeding mice

Mouse dams and their pups may benefit from more gradual weaning, but this is not possible in standard laboratory cages because dams cannot physically separate from their pups. Allowing mouse dams to control nursing may improve their welfare and encourage...

Year Published: 2024Topics: Rearing & WeaningAnimal Type: Mouse, Rodent

Citation: Ratuski, A. S., Makowska, I. J., Weary, D. M., 2024. Elevating the welfare of mouse dams: A pilot study on elevated tunnels for breeding mice. Laboratory Animal Science Professional 12(5) (September/October), 52–55.

The extent and function of ‘food grinding’ in the laboratory mouse (Mus musculus)

Many laboratory rodents grind their food into crumbs that are discarded at the bottom of the cage (sometimes called orts). This can have substantial impacts on measures of food intake and assimilation efficiency. We quantified food grinding in two laboratory...

Year Published: 2010Topics: Abnormal/Problematic BehaviorAnimal Type: Mouse, Rodent

Citation: Cameron, K. M., Speakman, J. R. 2010. The extent and function of ‘food grinding' in the laboratory mouse (Mus musculus). Laboratory Animals 44(4), 298-304.

Effect of ground transportation on adrenocortical activity in prepuberal female mice from five different genetic backgrounds

Specific experimental protocols necessitate transportation, a potentially stressful event that could confound results. We determined adrenocortical activity by measuring fecal corticosterone metabolites (FCMs), as a stress marker, in prepuberal (three-week old) female C57BL/6J, C57BL/6NCrl, FVB/NCrl, Crl:CD1(ICR), and BALB/cAnCrl mice. On...

Year Published: 2019Topics: Relocation & TransportAnimal Type: Mouse, Rodent

Citation: Rumpel, S., Scholl, C., Göbel, A. et al. 2019. Effect of ground transportation on adrenocortical activity in prepuberal female mice from five different genetic backgrounds. Animals 9(5), 239.

Comparison of sucrose and maltose as reinforcers in an operant choice paradigm

Two experiments compared the reinforcing effects of sucrose and maltose across a range of concentrations. The results were interpreted using the Multiplicative Hyperbolic Model of reinforcer value (MHM). In Experiment 1, rats were exposed to a discrete-trials schedule in which...

Year Published: 2024Topics: Animal TrainingAnimal Type: Rat, Rodent

Citation: Bradshaw, C. M. 2024. Comparison of sucrose and maltose as reinforcers in an operant choice paradigm. Behavioural Processes 220, 105075.

A new laboratory research model: The Damaraland mole-rat and its managed care

The Damaraland mole-rat (Fukomys damarensis) is a subterranean, hypoxia-tolerant, long-lived rodent endemic to southern and central Africa that is increasingly being used in laboratory research. Its husbandry needs and characteristics differ from traditional rodent research models. Here, we provide a...

Year Published: 2024Topics: Housing, Husbandry & ManagementAnimal Type: Mole Rat, Rodent

Citation: Buffenstein, R., Smith, M., Amoroso, V. G. et al. 2024. A new laboratory research model: The Damaraland mole-rat and its managed care. JAALAS 63(6), 683–693.

How much “enrichment” is enough for laboratory rodents? A systematic review and meta-analysis re-assessing the impact of well-resourced cages on morbidity and mortality

Laboratory rodent housing often fails to meet rodents' behavioral and physiological needs. We previously found that compared to well-resourced (often called 'enriched') housing, conventional cages increase mortality rates and the morbidity of stress-sensitive experimentally-induced diseases (anxiety, cancer, cardiovascular disease, depression,...

Year Published: 2024Topics: Environmental EnrichmentAnimal Type: Mouse, Rat, Rodent

Citation: Cait, J., Winder, C. B., Mason, G. J. 2024. How much “enrichment” is enough for laboratory rodents? A systematic review and meta-analysis re-assessing the impact of well-resourced cages on morbidity and mortality. Applied Animal Behaviour Science 278, 106361.

Evaluation of thermal support during anesthesia induction on body temperature in C57BL/6 and nude mice

Heat supplementation during surgery is a common practice; however, thermal support is not commonly used during anesthesia induction. Mice lose body temperature quickly, and air movement can exacerbate this, potentially putting mice at a thermal deficit before surgery. Whether the...

Year Published: 2024Topics: Anesthesia & SedationAnimal Type: Mouse, Rodent

Citation: Gaskill, B. N., Boykin, C., Zuniga, I. et al. 2024. Evaluation of thermal support during anesthesia induction on body temperature in C57BL/6 and nude mice. JAALAS 63(3), 294–302.

Periodic stays in a ‘playcage’ as an environmental enrichment measure for laboratory rats housed in individually ventilated cages: Short report

Male Zucker Diabetic Sprague Dawley rats were housed in standard individually ventilated cages with floor area of 1500 cm2, and were placed in a ‘playcage' (a large open cage) for three visits per week from the age of 16–18 weeks. The...

Year Published: 2024Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Gudbrandsen, O. A. 2024. Periodic stays in a ‘playcage' as an environmental enrichment measure for laboratory rats housed in individually ventilated cages: Short report. Laboratory Animals 58(4), 365–368.

Assessing susceptibility to carbon dioxide gas in three rat strains using the loss of righting reflex

Overdose of carbon dioxide gas (CO2) is a common euthanasia method for rodents; however, CO2 exposure activates nociceptors in rats at concentrations equal to or greater than 37% and is reported to be painful in humans at concentrations equal to...

Year Published: 2024Topics: EuthanasiaAnimal Type: Rat, Rodent

Citation: Merenick, D. R., Munro, B. A., Gee, J. M. et al. 2024. Assessing susceptibility to carbon dioxide gas in three rat strains using the loss of righting reflex. JAALAS 63(3), 310–315.

Pharmacokinetics of injectable meloxicam and buprenorphine in the naked mole-rat (Heterocephalus glaber)

Unique characteristics of the naked mole-rat (NMR) have made it increasingly popular as a laboratory animal model. These rodents are used to study many fields of research including longevity and aging, cancer, circadian rhythm, pain, and metabolism. Currently, the analgesic...

Year Published: 2024Topics: AnalgesiaAnimal Type: Other Rodent, Rodent

Citation: Moran, C. R., Park, T. J., Buffenstein, R. et al. 2024. Pharmacokinetics of injectable meloxicam and buprenorphine in the naked mole-rat (Heterocephalus glaber). JAALAS 63(5), 565–571.