Rodent

Severity classification of repeated isoflurane anesthesia in C57BL/6JRj mice—Assessing the degree of distress

According to the EU Directive 2010/63, the severity of a procedure has to be classified as mild, moderate or severe. General anesthesia is thought to be mild, but the Directive does not differentiate between single and repeated anesthesia. Therefore, we...

Year Published: 2017Topics: Anesthesia & SedationAnimal Type: Mouse, Rodent

Citation: Hohlbaum, K., Bert, B., Dietze, S. et al. 2017. Severity classification of repeated isoflurane anesthesia in C57BL/6JRj mice—Assessing the degree of distress. PLOS ONE 12(6), e0179588.

A study of the spontaneous activity of guinea pigs

Year Published: 1922Animal Type: Guinea Pig, Rodent

Citation: Nicholls, E. E. 1922. A study of the spontaneous activity of guinea pigs. Journal of Comparative Psychology 2, 303-330.

Studies of the thyroid apparatus. I. The stability of the nervous system as a factor in the resistance of the albino rat to the loss of the parathyroid secretion.

The relative mortality subsequent to thyroparathyroidectomy and parathyroidectomy of rats was much lower (13%) in animals who had been handled compared with animals who had not been handled (79%).

Year Published: 1921Topics: HandlingAnimal Type: Rat, Rodent

Citation: Hammett, F. S. 1921. Studies of the thyroid apparatus. I. The stability of the nervous system as a factor in the resistance of the albino rat to the loss of the parathyroid secretion. American Journal of Physiology 56, 196-204.

Fancy Mice, Fifth Edition

Adult males, on the other hand, must be housed separately, for, if put together, they will fight to the death. As already mentioned, young males of the same litter if never separated from birth may live together for some time,...

Year Published: 1912Animal Type: Mouse, Rodent

Citation: Davies, C. J. 1912. Fancy Mice, Fifth Edition. L Upcott Gill, London, UK.

Brief exposure to novel or enriched environments reduces sucrose cue-reactivity and consumption in rats after 1 or 30 days of forced abstinence from self-administration

Environmental enrichment (EE) reduces drug and sucrose cue-reactivity in rats. In a previous study we reported that 1 month of EE (large cage, toys, and social cohorts) significantly reduced sucrose cue-reactivity. In the present study, we examined whether overnight (22...

Year Published: 2013Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Grimm, J. W., Weber, R., Barnes, J. et al. 2013. Brief exposure to novel or enriched environments reduces sucrose cue-reactivity and consumption in rats after 1 or 30 days of forced abstinence from self-administration. PLOS ONE 8(1), e54164.

Differences in anticipatory behaviour between rats (Rattus norvegicus) housed in standard versus semi-naturalistic laboratory environments

Laboratory rats are usually kept in relatively small cages, but research has shown that they prefer larger and more complex environments. The physiological, neurological and health effects of standard laboratory housing are well established, but fewer studies have addressed the...

Year Published: 2016Topics: Emotion, Pain, & Sentience, Environmental Enrichment, HousingAnimal Type: Rat, Rodent

Citation: Makowska, I. J., Weary, D. M. 2016. Differences in anticipatory behaviour between rats (Rattus norvegicus) housed in standard versus semi-naturalistic laboratory environments. PLOS ONE 11(1), e0147595.

Effect of cage-induced stereotypies on measures of affective state and recurrent perseveration in CD-1 and C57BL/6 mice

Stereotypies are abnormal repetitive behaviour patterns that are highly prevalent in laboratory mice and are thought to reflect impaired welfare. Thus, they are associated with impaired behavioural inhibition and may also reflect negative affective states. However, in mice the relationship...

Year Published: 2016Topics: Abnormal/Problematic BehaviorAnimal Type: Mouse, Rodent

Citation: Novak, J., Bailoo, J. D., Melotti, L. et al. 2016. Effect of cage-induced stereotypies on measures of affective state and recurrent perseveration in CD-1 and C57BL/6 mice. PLOS ONE 11(5), e0153203.

Diffusion modelling reveals the decision making processes underlying negative judgement bias in rats

Human decision making is modified by emotional state. Rodents exhibit similar biases during interpretation of ambiguous cues that can be altered by affective state manipulations. In this study, the impact of negative affective state on judgement bias in rats was...

Year Published: 2016Topics: Welfare AssessmentAnimal Type: Rat, Rodent

Citation: Hales, C. A., Robinson, E. S. J., Houghton, C. J. 2016. Diffusion modelling reveals the decision making processes underlying negative judgement bias in rats. PLOS ONE 11(3), e0152592.

Whisker-eating mice

In all three cages dominance of one whisker eater over the other could be diagnosed within 24 hours. ... Hairs were eaten but not digested.

Year Published: 1952Animal Type: Mouse, Rodent

Citation: Hauschka, T. S. 1952. Whisker-eating mice. Journal of Heredity 43, 77-80.

Influence of environment on mammary tumors in mice

Group-housed animals are less suceptible to develop mammary tumors than individually housed animals.

Year Published: 1951Animal Type: Mouse, Rodent

Citation: Muhlbock, O. 1951. Influence of environment on mammary tumors in mice. Acta Unio Internationalis Contra Cancrum 7, 351-353.