Rat

Maternal deprivation impairs memory and cognitive flexibility, effect that is avoided by environmental enrichment

Maternal deprivation (MD) causes cognitive deficits that persist until adulthood. Thereby, the environmental enrichment (EE) is widely used to increase brain plasticity. Here, pregnant female rats were used and their offspring were submitted to neonatal MD from post-natal day 1–10;...

Year Published: 2020Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Menezes, J., Souto das Neves, B.-H., Gonçalves, R. et al. 2020. Maternal deprivation impairs memory and cognitive flexibility, effect that is avoided by environmental enrichment. Behavioural Brain Research 381, 112468.

Nesting material enrichment reduces severity of overgrooming-related self-injury in individually housed rats

Individual or singly-housing laboratory rats is common in many animal facilities, but has an adverse impact on the welfare of this social species. It has previously been shown that a small proportion of individually housed mice (∼5%) engage in pathological...

Year Published: 2020Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Khoo, S. Y.-S., Correia, V., Uhrig, A. 2020. Nesting material enrichment reduces severity of overgrooming-related self-injury in individually housed rats. Laboratory Animals 54(6), 546-558.

Individually ventilated cages severely attenuate inter-cage ultrasonic vocalizations in rats

Individually ventilated cages (IVCs) benefit rodent and researcher health but may limit animals’ ability to communicate with cage-neighbours via ultrasonic vocalizations (USVs). Despite USVs’ importance in rodent social behaviour, no previous research has investigated IVCs’ impact on between-cage USV transmission....

Year Published: 2025Topics: Housing, VocalizationAnimal Type: Rat, Rodent

Citation: Scott, K. J., Bilkey, D. K. 2025. Individually ventilated cages severely attenuate inter-cage ultrasonic vocalizations in rats. Journal of Applied Animal Welfare Science 28(4), 730–739.

Effects of dietary restriction on regulation of energy metabolism in male Wistar rats (Rattus norvegicus)

Laboratory rats are most often fed ad libitum (AL), but dietary restriction (DR) is commonly used to provide appropriate experimental designs. The current methods of DR have shortcomings; animals are often subjected to social isolation, periods of fasting, and disturbed...

Year Published: 2025Topics: Husbandry & ManagementAnimal Type: Rat, Rodent

Citation: Kasanen, I. H. E., Inhilä, K. J., Nevalainen, T. O. et al. 2025. Effects of dietary restriction on regulation of energy metabolism in male Wistar rats (Rattus norvegicus). JAALAS 64(4), 744–749.

Behavioral assessment of tramadol and meloxicam effects on postoperative pain in a rat craniotomy model

Stereotaxic surgery is a common procedure in neuroscience, yet effective analgesic protocols require further study and refinement to optimize the analgesia used in invasive procedures and to improve animal welfare. This study evaluated the effects of tramadol and meloxicam, alone...

Year Published: 2025Topics: Analgesia, Disease/Experimental ModelAnimal Type: Rat, Rodent

Citation: Alemán-Laporte, J., Alvarado, G., Pellagio, N. B. et al. 2025. Behavioral assessment of tramadol and meloxicam effects on postoperative pain in a rat craniotomy model. JAALAS 64(4), 716–725.

Germinating a novel idea to rodent heat support

An external heat source is frequently used to help rodents maintain optimal body temperature. The current gold standard for providing heat support to laboratory rodents is circulating warm water blankets. However, these come with certain drawbacks, including cost, the need...

Year Published: 2025Topics: Husbandry & Management, Surgery & Post-OpAnimal Type: Mouse, Rat, Rodent

Citation: Glaspell, S., Welch Jernigan, R. 2025. Germinating a novel idea to rodent heat support. Laboratory Animal Science Professional 13(3) (May/June), 23-24.

Juvenile male rats form preferences based on strain when playing in groups but not in pairs

Like many young mammals, juvenile rats engage in rough-and-tumble play. Play occurs naturally both in wild and laboratory rats, making it a suitable, ethologically relevant behavior to investigate. In the laboratory, rats are typically housed and tested in dyads, despite...

Year Published: 2025Topics: Social Housing & CompanionshipAnimal Type: Rat, Rodent

Citation: Ham, J. R., Jaiswal, D., Waner-Mariquito, R. et al. 2025. Juvenile male rats form preferences based on strain when playing in groups but not in pairs. Frontiers in Behavioral Neuroscience 19.

Housing in a large open cage did not affect the phenotypic traits of obese male Zucker fa/fa rats when compared to IVC-housed rats, but improved the rats’ well-being

The housing of laboratory rats in cages with dimensions according to international standards for research animals can hardly be regarded as a stimulating environment, even when fulfilling the minimum requirements for environmental enrichment. Little is known about whether changes in...

Year Published: 2025Topics: Disease/Experimental Model, HousingAnimal Type: Rat, Rodent

Citation: Gudbrandsen, O. A. 2025. Housing in a large open cage did not affect the phenotypic traits of obese male Zucker fa/fa rats when compared to IVC-housed rats, but improved the rats’ well-being. Animals 15(18), 2687.

Environmental enrichment for laboratory rats and mice: Endocrine, physiological, and behavioral benefits of meeting rodents’ biological needs

Standard housing for laboratory rodents is characterized by cages that do not always provide an adequate environment to meet the animal’s behavioral needs. When animals are reared under impoverished conditions, negative states such as boredom and distress might arise. Environmental...

Year Published: 2025Topics: Environmental EnrichmentAnimal Type: Mouse, Rat, Rodent

Citation: Domínguez-Oliva, A., Hernández-Avalos, I., Bueno-Nava, A. et al. 2025. Environmental enrichment for laboratory rats and mice: Endocrine, physiological, and behavioral benefits of meeting rodents’ biological needs. Frontiers in Veterinary Science 12.

Rat boredom-like behaviour in a monotonous versus a varied foraging task: Effects of sensory variation

Evidence increasingly reveals that non-human animals in monotonous situations can show boredom-like states, distinctively manifesting as increases in both arousal-seeking, restless behaviour and low arousal, drowsy behaviour. However, task related boredom has been little investigated in animals, but could have...

Year Published: 2025Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Burn, C. C., Ng, K. H. T., Parker, M. O. 2025. Rat boredom-like behaviour in a monotonous versus a varied foraging task: Effects of sensory variation. Animal Cognition 28(1), 57.