Rat

Applying refinement to the use of mice and rats in rheumatoid arthritis research

Rheumatoid arthritis (RA) is a painful, chronic disorder and there is currently an unmet need for effective therapies that will benefit a wide range of patients. The research and development process for therapies and treatments currently involves in vivo studies,...

Year Published: 2015Topics: Disease/Experimental ModelAnimal Type: Mouse, Rat, Rodent

Citation: Hawkins, P., Armstrong, R., Boden, T. et al. 2015. Applying refinement to the use of mice and rats in rheumatoid arthritis research. Inflammopharmacology 23, 131–150.

Distinct profiles of 50 kHz vocalizations differentiate between social versus non-social reward approach and consumption

Social animals tend to possess an elaborate vocal communication repertoire, and rats are no exception. Rats utilize ultrasonic vocalizations (USVs) to communicate information about a wide range of socially relevant cues, as well as information regarding the valence of the...

Year Published: 2021Topics: VocalizationAnimal Type: Rat, Rodent

Citation: Seidisarouei, M., van Gurp, S., Pranic, N. M. et al. 2021. Distinct profiles of 50 kHz vocalizations differentiate between social versus non-social reward approach and consumption. Frontiers in Behavioral Neuroscience 15, 693698.

A sensitive homecage-based novel object recognition task for rodents

The recognition of novel objects is a common cognitive test for rodents, but current paradigms have limitations, such as low sensitivity, possible odor confounds and stress due to being performed outside of the homecage. We have developed a paradigm that...

Year Published: 2021Topics: Behavioral & Cognitive TestingAnimal Type: Mouse, Rat, Rodent

Citation: Wooden, J. I., Spinetta, M. J., Nguyen, T. et al. 2021. A sensitive homecage-based novel object recognition task for rodents. Frontiers in Behavioral Neuroscience 15, 680042.

Crying with laughter: Adapting the tickling protocol to address individual differences among rats in their response to playful handling

In this Opinion paper, we consider whether current methods of tickling overemphasize the use of pinning (Figure 1) to which there may be a wider response variation than commonly acknowledged. We do not dispute that tickling can be a positive...

Year Published: 2021Topics: Handling, Human-Animal InteractionAnimal Type: Rat, Rodent

Citation: Bombail, V., Brown, S. M., Hammond, T. J. et al. 2021. Crying with laughter: Adapting the tickling protocol to address individual differences among rats in their response to playful handling. Frontiers in Veterinary Science 8, 677872.

A good life for laboratory rodents?

Most would agree that animals in research should be spared “unnecessary” harm, pain, or distress, and there is also growing interest in providing animals with some form of environmental enrichment. But is this the standard of care that we should...

Year Published: 2019Topics: Environmental Enrichment, Handling, Housing, Husbandry & Management, Natural Behavior, RestraintAnimal Type: Mouse, Rat, Rodent

Citation: Makowska, I. J., Weary, D. M. 2019. A good life for laboratory rodents? ILAR Journal 60(3), 373-388.

The interactive stress assessment in basic animal science training

In order to assess the extent to which the legally prescribed training for the acquisition of animal experimentation expertise provides scientific personnel with the necessary competence and expertise to carry out a correct harm-benefit analysis in the context of animal...

Year Published: 2021Topics: Welfare AssessmentAnimal Type: All/General, Guinea Pig, Mouse, Rabbit, Rat, Rodent, Sheep

Citation: Manthey, T., Nagel-Riedasch, S., Dülsner, A. 2021. The interactive stress assessment in basic animal science training. Animals 11(7), 2145.

Refinement of animal model of colorectal carcinogenesis through the definition of novel humane endpoints

This study aimed to define appropriate humane endpoints (HEs) for an animal model of colorectal carcinogenesis (CRC). Twenty-nine male Wistar rats were divided into two control groups (CTRL1 and CTRL2) injected with ethylenediamine tetraacetic acid (EDTA)–saline solutions and two induced...

Year Published: 2021Topics: Disease/Experimental Model, Humane EndpointAnimal Type: Rat

Citation: Silva-Reis, R., Faustino-Rocha, A. I., Gonçalves, M. et al. 2021. Refinement of animal model of colorectal carcinogenesis through the definition of novel humane endpoints. Animals 11(4), 985.

Evaluation of potential sustainable bedding substrates focusing on preference, behavior, and stress physiology in rats—A pilot study

Ensuring optimal housing conditions for laboratory animals is a crucial prerequisite for high-quality and ethically justifiable in vivo science. In addition to guaranteeing animal welfare and promoting scientific validity, environmental sustainability is also increasingly gaining attention in laboratory animal facilities....

Year Published: 2021Topics: Husbandry & ManagementAnimal Type: Rat, Rodent

Citation: Vogt, M. A., Geiger, L. M. J., Härtel, T. et al. 2021. Evaluation of potential sustainable bedding substrates focusing on preference, behavior, and stress physiology in rats—A pilot study. Animals 11(5), 1375.

Report of the 2020 RSPCA/UFAW rodent and rabbit welfare meeting

The RSPCA/UFAW rodent and rabbit welfare group has held a one-day meeting every autumn for the last 27 years, so that its members can discuss current welfare research, exchange views on welfare issues and share experiences of the implementation of...

Year Published: 2021Topics: Drug/Substance Administration, Environmental Enrichment, Handling, Housing, Welfare AssessmentAnimal Type: Mouse, Rat, Rodent

Citation: Stevens, C., Hawkins, P., Smulders, T. V. et al. 2021. Report of the 2020 RSPCA/UFAW rodent and rabbit welfare meeting. Animal Technology and Welfare 20(1), 21-33.

A novel dietary restriction method for group-housed rats: Weight gain and clinical chemistry characterization

Laboratory rodents are usually fed ad libitum. Moderate dietary restriction decreases mortality and morbidity compared with ad libitum feeding. There are, however, problems in achieving dietary restriction. Traditional methods of restricted feeding may interfere with the diurnal rhythms of the...

Year Published: 2009Topics: Environmental Enrichment, Husbandry & ManagementAnimal Type: Rat, Rodent

Citation: Kasanen, I. H. E., Inhilä, K. J., Nevalainen, J. I. et al. 2009. A novel dietary restriction method for group-housed rats: Weight gain and clinical chemistry characterization. Laboratory Animals 43, 138-148.