Nonhuman Primate

Less invasive, simultaneous, and continuous measurements of locomotor activity and body temperature using the nano tag® small accelerometer device in cynomolgus monkeys

Locomotor activity and body temperature evaluations of cynomolgus monkeys are useful to understand the effects of drugs on the central nervous system. Here, we describe a simple, inexpensive, and less invasive evaluation method using the nano tag® (KISSEI COMTEC Co.,...

Year Published: 2022Topics: Biological Sampling & Physiological MeasurementAnimal Type: Macaque, Nonhuman Primate

Citation: Kishida, T., Motokawa, Y., Yokoi, R. et al. 2022. Less invasive, simultaneous, and continuous measurements of locomotor activity and body temperature using the nano tag® small accelerometer device in cynomolgus monkeys. Journal of Pharmacological and Toxicological Methods 118, 107224.

Blood microsampling in cynomolgus monkey and evaluation of plasma PK parameters in comparison to conventional sampling

Microsampling, a reduced volume sampling method, has successfully gained attention at the International Conference on Harmonization (ICH) level and established benefits support its use in Toxicokinetic (TK) studies. These improved sampling techniques are less invasive and in large animal species...

Year Published: 2023Topics: Biological Sampling & Physiological MeasurementAnimal Type: Macaque, Nonhuman Primate

Citation: Bertani, S., Donadi, A., Franchi, J. et al. 2023. Blood microsampling in cynomolgus monkey and evaluation of plasma PK parameters in comparison to conventional sampling. Journal of Pharmacological and Toxicological Methods 123, 107298.

Nonhuman primate enrichment evaluation program

Noting that it is typical for enrichment devices to be approved by a committee and understanding that this is paramount for animal safety, we began to think outside the box and seek additional ways to approve enrichment devices for the...

Year Published: 2023Topics: Environmental EnrichmentAnimal Type: Macaque, Nonhuman Primate

Citation: Deugan, C. R., Gross, A. A. 2023. Nonhuman primate enrichment evaluation program. Laboratory Animal Science Professional 11(2) (March/April), 46-49.

Thirty years of telemetry-based data acquisition for cardiovascular drug safety evaluation: Applications and optimization

Conducting safety evaluations of new drugs using conscious animals has been a specialty of our working group for thirty years. In this article, we review the various technical challenges and solutions dealt with over the years to improve both the...

Year Published: 2023Topics: Biological Sampling & Physiological Measurement, External Bodily EquipmentAnimal Type: Dog, Guinea Pig, Macaque, Mouse, Nonhuman Primate, Pig, Rat, Rodent

Citation: Alizadeh, E. A., Graf, K., Schiwon, J. et al. 2023. Thirty years of telemetry-based data acquisition for cardiovascular drug safety evaluation: Applications and optimization. Journal of Pharmacological and Toxicological Methods 122, 107279.

Association of Primate Veterinarians guidelines for domestic transport of nonhuman primates in biomedical research

The purpose of this guidance document is to provide veterinarians and other individuals associated with domestic transportation of nonhuman primates (NHP) with an overview of the critical aspects of the process including planning, execution, and post-transport phases. These guidelines are...

Year Published: 2023Topics: Relocation & TransportAnimal Type: Nonhuman Primate

Citation: Association of Primate Veterinarians. 2023. Association of Primate Veterinarians guidelines for domestic transport of nonhuman primates in biomedical research. JAALAS 62(3), 198-201.

The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals (9th ed.)

The latest edition of the seminal reference on the care and management of laboratory and research animals. The newly revised ninth edition of The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals delivers an up-to-date...

Year Published: 2024Topics: Animal Training, Environmental Enrichment, Euthanasia, Housing, Husbandry & Management, Natural Behavior, Relocation & Transport, Welfare AssessmentAnimal Type: Amphibian, Bird, Capuchin, Cat, Cattle, Cephalopod, Crustacean, Dog, Equine, Ferret, Finch, Fish, Fowl, Frog & Toad, Gerbil, Goat, Guinea Pig, Hamster, Invertebrate, Lizard, Macaque, Marmoset, Mole Rat, Mouse, Nonhuman Primate, Other Animal, Other Bird, Other Fish, Other Nonhuman Primate, Other Rodent, Pig, Rabbit, Rat, Reptile, Rodent, Sheep, Snake, Tree Shrew, Turtle & Tortoise, Vervet (African Green Monkey), Zebrafish

Citation: Golledge, H., Richardson, C. (Eds.) 2024. The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals (9th ed.). Wiley-Blackwell. 1040 p.

Early social deprivation negatively affects social skill acquisition in chimpanzees (Pan troglodytes)

In a highly social species like chimpanzees, the process by which individuals become attuned to their social environment may be of vital importance to their chances of survival. Typically, this socialization process, defined by all acquisition experiences and fine-tuning efforts...

Year Published: 2014Topics: Rearing & Weaning, Social Housing & CompanionshipAnimal Type: Chimpanzee, Nonhuman Primate

Citation: van Leeuwen, E. J. C., Mulenga, I. C., Chidester, D. L. 2014. Early social deprivation negatively affects social skill acquisition in chimpanzees (Pan troglodytes). Animal Cognition 17(2), 407–414.

Stereotypic head twirls, but not pacing, are related to a ‘pessimistic’-like judgment bias among captive tufted capuchins (Cebus apella)

Abnormal stereotypic behaviour is widespread among captive non-human primates and is generally associated with jeopardized well-being. However, attributing the same significance to all of these repetitive, unvarying and apparently functionless behaviours may be misleading, as some behaviours may be better...

Year Published: 2012Topics: Abnormal/Problematic Behavior, Welfare AssessmentAnimal Type: Capuchin, Nonhuman Primate

Citation: Pomerantz, O., Terkel, J., Suomi, S. J. et al. 2012. Stereotypic head twirls, but not pacing, are related to a ‘pessimistic'-like judgment bias among captive tufted capuchins (Cebus apella). Animal Cognition 15(4), 689–698.

A fine-scale and minimally invasive marking method for use with conventional tungsten microelectrodes

In neurophysiology, achieving precise correlation between physiological responses and anatomic structures is a significant challenge. Therefore, the accuracy of the electrode marking method is crucial. In this study, we describe a tungsten-deposition method, in which tungsten oxide is generated by...

Year Published: 2023Topics: Imaging & Electrophysiological RecordingAnimal Type: Macaque, Mouse, Nonhuman Primate, Rodent

Citation: Oikawa, T., Nomura, K., Hara, T. et al. 2023. A fine-scale and minimally invasive marking method for use with conventional tungsten microelectrodes. eNeuro 10(9), ENEURO.0141-23.2023.

Mechanisms underlying cognitive bias in nonhuman primates

Recent research in nonhuman animals highlights the exciting possibility that performance on cognitive bias tasks might indirectly measure an individual's subjective, affective state. Subjects first learn to perform a conditional discrimination task with two differentially reinforced responses, and then intermediate,...

Year Published: 2017Topics: Welfare AssessmentAnimal Type: Capuchin, Macaque, Nonhuman Primate

Citation: Perdue, B. 2017. Mechanisms underlying cognitive bias in nonhuman primates. Animal Behavior and Cognition 4(1), 105–118.