Mouse

Optimization of ketamine/xylazine anesthesia in geriatric mice

Aged mice are becoming increasingly important models for human senescence. Many studies require anesthesia. Standard rodent ketamine/xylazine injectable regimens have been associated with increased incidences of death, unreliable surgical planes, and prolonged recoveries in geriatric mice. We hypothesized that the...

Year Published: 2025Topics: Anesthesia & SedationAnimal Type: Mouse, Rodent

Citation: Beecy, S., Meuse, D., Kizielewicz, N. et al. 2025. Optimization of ketamine/xylazine anesthesia in geriatric mice. JAALAS 64(4), 778–787.

Differential long-term effects of physical, social, and psychological stressors in male mice: Down-regulation of inflammatory markers and unresponsiveness of the antioxidant system

The long-term molecular consequences associated with post-traumatic stress disorder (PTSD) are poorly understood. Our study examined the long-term (up to five months) metabolic consequences of acute and chronic traumatic factors, including physical (2-hour restraint), psychological (predator sound), and social (social...

Year Published: 2025Topics: Restraint, Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Balatskyi, V., Gospodaryov, D., Abrat, O. et al. 2025. Differential long-term effects of physical, social, and psychological stressors in male mice: Down-regulation of inflammatory markers and unresponsiveness of the antioxidant system. Physiology & Behavior 301, 115065.

Germinating a novel idea to rodent heat support

An external heat source is frequently used to help rodents maintain optimal body temperature. The current gold standard for providing heat support to laboratory rodents is circulating warm water blankets. However, these come with certain drawbacks, including cost, the need...

Year Published: 2025Topics: Husbandry & Management, Surgery & Post-OpAnimal Type: Mouse, Rat, Rodent

Citation: Glaspell, S., Welch Jernigan, R. 2025. Germinating a novel idea to rodent heat support. Laboratory Animal Science Professional 13(3) (May/June), 23-24.

Automated facial feature evaluation system to prevent stress of head fixed mice

Head fixation of rodents is a widely utilized and important technique that enables laboratories to measure brain activity during behavior, but head fixation can increase stress which affects both behavior and underlying brain activity, as well as animal welfare. It...

Year Published: 2025Topics: Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Nasr, A., Rettinger, G., Mansvelder, H. D. et al. 2025. Automated facial feature evaluation system to prevent stress of head fixed mice. PLOS ONE 20(6), e0322530.

Enrichment for stud males in MRC Ares

Sometimes within the laboratory environment mice may be housed on their own for example when being used as studs for cryopreservation. As these animals do not have a companion for enrichment it is important that these mice are provided with...

Year Published: 2025Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: McCool, J. 2025. Enrichment for stud males in MRC Ares. Animal Technology and Welfare 24(2), 149–150.

Body condition scoring and weighing—Going combo!

Evaluating an animal’s nutritional status and overall fitness ensures its welfare. While weight is often used as a single proxy for overall fitness, it may not capture changes in muscle or fat mass on its own. This is why body...

Year Published: 2025Topics: Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: McClenaghan, M., Galichet, C., Murphy, S. et al. 2025. Body condition scoring and weighing—Going combo! Animal Technology and Welfare 24(2), 138–140.

A survey on the implementation of environmental health monitoring in mouse facilities in German-speaking countries

The health status of laboratory animals plays a decisive role not only for the health and welfare of the animals but also for the validity of study results. In recent years, there has been an increasing number of publications on...

Year Published: 2025Topics: Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Mahabir, E., Schmidt, K., Kolbe, T. et al. 2025. A survey on the implementation of environmental health monitoring in mouse facilities in German-speaking countries. PLOS ONE 20(10), e0334442.

Sleep preferences in CD1 mice in a laboratory environment

This study investigates the preferences of CD1 mice in a lab environment for various sleeping enrichment options within their cages. Understanding the environmental factors that influence sleep behaviour is crucial for enhancing animal welfare in laboratory settings. We assessed two...

Year Published: 2025Topics: Environmental Enrichment, Husbandry & Management, Natural BehaviorAnimal Type: Mouse, Rodent

Citation: Mackay, F., Teggart, M. 2025. Sleep preferences in CD1 mice in a laboratory environment. Animal Technology and Welfare 24(2), 175–176.

Chew sticks, do mice really care?

There are various chewing enrichments on the market for small rodents. In this study we focused on comparing two types, T-Brick and Aspen to see which product enabled more natural chewing behaviours in several strains of mice. A rack of...

Year Published: 2025Topics: Environmental Enrichment, Natural BehaviorAnimal Type: Mouse, Rodent

Citation: Higginson, K. 2025. Chew sticks, do mice really care? Animal Technology and Welfare 24(2), 185–187.

Environmental enrichment for laboratory rats and mice: Endocrine, physiological, and behavioral benefits of meeting rodents’ biological needs

Standard housing for laboratory rodents is characterized by cages that do not always provide an adequate environment to meet the animal’s behavioral needs. When animals are reared under impoverished conditions, negative states such as boredom and distress might arise. Environmental...

Year Published: 2025Topics: Environmental EnrichmentAnimal Type: Mouse, Rat, Rodent

Citation: Domínguez-Oliva, A., Hernández-Avalos, I., Bueno-Nava, A. et al. 2025. Environmental enrichment for laboratory rats and mice: Endocrine, physiological, and behavioral benefits of meeting rodents’ biological needs. Frontiers in Veterinary Science 12.