Mouse

Environmental enrichment rescues visually-mediated behavior in Ten-m3 knockout mice during an early critical period

Environmental enrichment (EE) has been shown to promote neural plasticity. Its capacity to induce functional repair in models which exhibit profound sensory deficits due to aberrant axonal guidance has not been well-characterized. Ten-m3 knockout (KO) mice exhibit a highly-stereotyped miswiring...

Year Published: 2020Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Blok, J., Black, D. A., Petersen, J. et al. 2020. Environmental enrichment rescues visually-mediated behavior in Ten-m3 knockout mice during an early critical period. Frontiers in Behavioral Neuroscience 14, 22.

Evaluating intrahepatic and intraperitoneal sodium pentobarbital or ethanol for mouse euthanasia

Intraperitoneal (IP) injection of sodium pentobarbital (PB) is an accepted method of euthanasia for mice. However, this method has important drawbacks, including the potential for pain or misinjection. The objective of this prospective, randomized, blinded study was to determine whether...

Year Published: 2020Topics: EuthanasiaAnimal Type: Mouse, Rodent

Citation: Laferriere, C. A., Leung, V. S., Pang, D. S. 2020. Evaluating intrahepatic and intraperitoneal sodium pentobarbital or ethanol for mouse euthanasia. JAALAS 59(3), 264–268.

Evaluation of cotton dental rolls as environmental enrichment for mice

Historically, we provided 2 compressed cotton squares for nesting and enrichment. The logistics of managing nesting material distribution, disposal, and costs are major considerations for our program, which provides husbandry to approximately 60,000 rodent cages weekly. We identified cotton dental...

Year Published: 2020Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Rodgers, J. C., Ricart Arbona, R. J., Lieggi, C. et al. 2020. Evaluation of cotton dental rolls as environmental enrichment for mice. Laboratory Animal Science Professional 8(5) (September/October), 70-71.

Effect of a partial cage dividing enrichment on aggression-associated parameters in group-housed male C57BL/6NCrl mice

Group-housing is highly important for social animals. Group-housing of male mice in captivity though often leads to aggression with partially disastrous consequences for the animals as well as for the quality of experimental data. In this study we investigated the...

Year Published: 2020Topics: Environmental Enrichment, HousingAnimal Type: Mouse, Rodent

Citation: Mertens, S., Gass, P., Palme, R. et al. 2020. Effect of a partial cage dividing enrichment on aggression-associated parameters in group-housed male C57BL/6NCrl mice. Applied Animal Behaviour Science 224, 104939.

Effect of repeated exposure to isoflurane on nest building and burrowing in mice

Nest building and burrowing are highly motivated natural behaviors in rodents, and changes in these behaviors can serve as welfare assessment tools. In this study, we investigated: 1) the limits of agreement between 2 observers for a refined scoring method...

Year Published: 2020Topics: Anesthesia & Sedation, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Gjendal, K., Ottesen, J. L., Olsson, I. et al. 2020. Effect of repeated exposure to isoflurane on nest building and burrowing in mice. JAALAS 59(1), 30–36.

Effects of enriched housing on the neuronal morphology of mice that lack zinc transporter 3 (ZnT3) and vesicular zinc

In the central nervous system, certain neurons store zinc within the synaptic vesicles of their axon terminals. This vesicular zinc can then be released in an activity-dependent fashion as an intercellular signal. The functions of vesicular zinc are not entirely...

Year Published: 2020Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: McAllister, B. B., Thackray, S. E., Garciá de la Orta, B. K. et al. 2020. Effects of enriched housing on the neuronal morphology of mice that lack zinc transporter 3 (ZnT3) and vesicular zinc. Behavioural Brain Research 379, 112336.

Effects of repetitive gentle handling of male C57BL/6NCrl mice on comparative behavioural test results

Mice are the most commonly used laboratory animals for studying diseases, behaviour, and pharmacology. Behavioural experiment battery aids in evaluating abnormal behaviour in mice. During behavioural experiments, mice frequently experience human contact. However, the effects of repeated handling on mice...

Year Published: 2020Topics: HandlingAnimal Type: Mouse, Rodent

Citation: Ueno, H., Takahashi, Y., Suemitsu, S. et al. 2020. Effects of repetitive gentle handling of male C57BL/6NCrl mice on comparative behavioural test results. Scientific Reports 10(1), 3509.

Effects of trio and pair breeding of mice on environmental parameters and nasal pathology and their implications for cage change frequency

According to the Guide, cage change frequencies must be considered when cage density requirements are exceeded. We monitored ammonia, carbon dioxide, cage wetness, health status, and breeding parameters of trio and pair breeding cages containing CD1 mice in ventilated and...

Year Published: 2020Topics: Husbandry & Management, ReproductionAnimal Type: Mouse, Rodent

Citation: Carpenter, K. C., Thurston, S. E., Hoenerhoff, M. J. et al. 2020. Effects of trio and pair breeding of mice on environmental parameters and nasal pathology and their implications for cage change frequency. JAALAS 59(3), 288–297.

Effects of weaning age and housing conditions on phenotypic differences in mice

Poor reproducibility is considered a serious problem in laboratory animal research, with important scientific, economic, and ethical implications. One possible source of conflicting findings in laboratory animal research are environmental differences between animal facilities combined with rigorous environmental standardization within...

Year Published: 2020Topics: Rearing & WeaningAnimal Type: Mouse, Rodent

Citation: Bailoo, J. D., Voelkl, B., Varholick, J. et al. 2020. Effects of weaning age and housing conditions on phenotypic differences in mice. Scientific Reports 10, 11684.

Eliminating light-at-night contamination during a lab animal facility renovation

Relocating laboratory animal research from one animal facility room to another in advance of major renovations can be a daunting task for scientists and animal care personnel alike. This is especially so regarding controlled lighting and the elimination of light-at-night...

Year Published: 2020Topics: Husbandry & ManagementAnimal Type: Chinchilla, Gerbil, Guinea Pig, Hamster, Mouse, Other Rodent, Rat, Rodent

Citation: Dupepe, L. M., Dauchy, R. T., McAndrew, D. et al. 2020. Eliminating light-at-night contamination during a lab animal facility renovation. Laboratory Animal Science Professional 8(5) (September/October), 60-62.