Mouse

Behavioral responses of CD-1 mice to conspecific and heterospecific blood odors and to a blood odor component

The odor of blood may have both aversive and attractive properties for mammals, depending on the species of the odor donor and the species perceiving the odor. To better understand the informational content of blood odor for a prey species...

Year Published: 2018Topics: EuthanasiaAnimal Type: Mouse, Rodent

Citation: Lahger, C., Laska, M. 2018. Behavioral responses of CD-1 mice to conspecific and heterospecific blood odors and to a blood odor component. Physiology & Behavior 184, 2015-210.

Assessing the exploratory and anxiety-related behaviors of mice

Ample studies have shown that housing can affect the health, welfare and behavior of mice and therefore, the outcomes of certain experiments. The aim of this study was to investigate if three widely used housing systems, Open Top Cages (OTC),...

Year Published: 2017Topics: Emotion, Pain, & Sentience, HousingAnimal Type: Mouse, Rodent

Citation: Polissidis, A., Zelelak, S., Nikita, M. et al. 2017. Assessing the exploratory and anxiety-related behaviors of mice. Do different caging systems affect the outcome of behavioral tests? Physiology & Behavior 177, 68-73.

A comparison of two types of running wheel in terms of mouse preference, health, and welfare

Voluntary wheel running occurs in mice of all strains, sexes, and ages. Mice find voluntary wheel running rewarding, and it leads to numerous health benefits. For this reason wheels are used both to enhance welfare and to create models of...

Year Published: 2018Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Walker, M., Mason, G. 2018. A comparison of two types of running wheel in terms of mouse preference, health, and welfare. Physiology & Behavior 191, 82-90.

The biology and husbandry of the African spiny mouse (Acomys cahirinus) and the research uses of a laboratory colony

African spiny mice (Acomysspp.) are unique precocial rodents that are found in Africa, the Middle East, and southern Asia. They exhibit several interesting life-history characteristics, including precocial development, communal breeding, and a suite of physiologic adaptations to desert life. In...

Year Published: 2016Topics: Husbandry & Management, Natural Behavior, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Haughton, C. L., Gawriluk, T. R., Seifert, A. W. 2016. The biology and husbandry of the African spiny mouse (Acomys cahirinus) and the research uses of a laboratory colony. JAALAS 55(1), 9–17.

Handling method alters the hedonic value of reward in laboratory mice

Mice are the most widely used model species for drug discovery and scientific research. Consequently, it is important to refine laboratory procedures and practices to ensure high standards of welfare and scientific data quality. Recent studies have identified that the...

Year Published: 2018Topics: HandlingAnimal Type: Mouse, Rodent

Citation: Clarkson, J. M., Dwyer, D. M., Flecknell, P. A. et al. 2019. Handling method alters the hedonic value of reward in laboratory mice. Scientific Reports 8, 2448.

Body temperature measurement in mice during acute illness: Implantable temperature transponder versus surface infrared thermometry

Body temperature is a valuable parameter in determining the wellbeing of laboratory animals. However, using body temperature to refine humane endpoints during acute illness generally lacks comprehensiveness and exposes to inter-observer bias. Here we compared two methods to assess body...

Year Published: 2018Topics: Biological Sampling & Physiological Measurement, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Mei, J., Riedel, N., Grittner, U. et al. 2018. Body temperature measurement in mice during acute illness: Implantable temperature transponder versus surface infrared thermometry. Scientific Reports 8, 3526.

Comparison of atipamezole with yohimbine for antagonism of xylazine in mice anesthetized with ketamine and xylazine

The α2 adrenergic agonist xylazine produces a sedative effect and is typically combined with ketamine and used for anesthesia or chemical restraint of laboratory mice. Xylazine's sedative effect—and its undesirable side effects of bradycardia, hypotension, and poor tissue perfusion—can be...

Year Published: 2017Topics: Anesthesia & SedationAnimal Type: Mouse, Rodent

Citation: Janssen, C. F., Maiello, P., Wright Jr, M. J. et al. 2017. Comparison of atipamezole with yohimbine for antagonism of xylazine in mice anesthetized with ketamine and xylazine. JAALAS 56(2), 142-147.

Benefits of 21% oxygen compared with 100% oxygen for delivery of isoflurane to mice (Mus musculus) and rats (Rattus norvegicus)

At research institutions, isoflurane delivered by precision vaporizer to a face mask is the standard for rodent surgery and for procedures with durations that exceed a few minutes. Pure oxygen is often used as the carrier gas for isoflurane anesthesia,...

Year Published: 2017Topics: Anesthesia & SedationAnimal Type: Mouse, Rat, Rodent

Citation: Wilding, L. A., Hampel, J. A., Khoury, B. M. et al. 2017. Benefits of 21% oxygen compared with 100% oxygen for delivery of isoflurane to mice (Mus musculus) and rats (Rattus norvegicus). JAALAS 56(2), 148-154.

A device that allows rodents to behaviorally thermoregulate when housed in vivariums

Laboratories and vivariums typically are maintained at ambient temperatures of 20 to 24 °C, leading to cold stress in mice. When mice are inactive and sleeping during the light phase, their zone of thermoneutrality associated with a basal metabolic rate...

Year Published: 2017Topics: Husbandry & ManagementAnimal Type: Mouse, Rat, Rodent

Citation: Gordon, C. J., Puckett, E. T., Repasky, E. S. et al. 2017. A device that allows rodents to behaviorally thermoregulate when housed in vivariums. JAALAS 56(2), 173-176.

What goes around can come around: An unexpected deleterious effect of using mouse running wheels for environmental enrichment

Environmental enrichment items such as running wheels can promote the wellbeing of laboratory mice. Growing evidence suggests that wheel running simulates exercise effects in many mouse models of human conditions, but this activity also might change other aspects of mouse...

Year Published: 2017Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Leduc, R. Y. M., Rauw, G., Baker, G. B. et al. 2017. What goes around can come around: An unexpected deleterious effect of using mouse running wheels for environmental enrichment. JAALAS 56(2), 194-201.