Mouse

Analgesic efficacy and hematologic effects of robenacoxib in mice

NSAID analgesics may confound models that require inflammation to mimic disease development in humans. This effect presents a challenge for veterinary staff and investigators, because surgery is often necessary to create mouse models of disease and NSAID are first-line analgesics...

Year Published: 2018Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Beninson, J. A., Lofgren, J. L., Lester, P. A. et al. 2018. Analgesic efficacy and hematologic effects of robenacoxib in mice. JAALAS 57(3), 258-267.

Refinement of perioperative feeding in a mouse model of vertical sleeve gastrectomy

Provision of liquid enteral nutrition (LEN) during the perioperative period is standard practice for rodents undergoing bariatric surgery, yet these diets are associated with several challenges, including coagulation of the liquid diet within the delivery system and decreased postoperative consumption....

Year Published: 2018Topics: Disease/Experimental Model, Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Doerning, C. M., Burlingame, L. A., Lewis, A. G. et al. 2018. Refinement of perioperative feeding in a mouse model of vertical sleeve gastrectomy. JAALAS 57(3), 295-301.

Out like a light? The effects of a diurnal husbandry schedule on mouse sleep and behavior

Sleep disruption in humans, caused by shift work, can be detrimental to physical and behavioral health. Nocturnal laboratory mice may experience a similar disruption caused by human daytime activities, but whether this disruption affects their welfare is unknown. We used...

Year Published: 2018Topics: Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Robinson-Junker, A. L., O'hara, B. F., Gaskill, B. N. 2018. Out like a light? The effects of a diurnal husbandry schedule on mouse sleep and behavior. JAALAS 57(2), 124-133.

Using cageside measures to evaluate analgesic efficacy in mice (Mus musculus) after surgery

Recent studies have revealed some of the most frequently used analgesics in mice are not effectively treating postoperative pain. Our laboratory sought to compare and assess the validity and reliability of 2 cageside pain assessments that we recently developed for...

Year Published: 2018Topics: Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Oliver, V. L., Thurston, S. E., Lofgren, J. L. 2018. Using cageside measures to evaluate analgesic efficacy in mice (Mus musculus) after surgery. JAALAS 57(2), 186-201.

A good death? Report of the second Newcastle meeting on laboratory animal euthanasia

Millions of laboratory animals are killed each year worldwide. There is an ethical, and in many countries also a legal, imperative to ensure those deaths cause minimal suffering. However, there is a lack of consensus regarding what methods of killing...

Year Published: 2016Topics: EuthanasiaAnimal Type: Fish, Mouse, Rat, Rodent, Zebrafish

Citation: Hawkins, P., Prescott, M., Carbone, L. et al. 2016. A good death? Report of the second Newcastle meeting on laboratory animal euthanasia. Animals 6(9), 50.

Effects of various cleaning agents on the performance of mice in behavioral assays of anxiety

Cleaning behavioral equipment between rodent subjects is important to prevent disease transmission and reduce odor cues from previous subjects. However, the reporting regarding the cleansing procedures used during such experiments is sporadic and often incomplete. In addition, some investigators are...

Year Published: 2018Topics: Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Hershey, J. D., Gifford, J. J., Zizza, L. J. et al. 2018. Effects of various cleaning agents on the performance of mice in behavioral assays of anxiety. JAALAS 57(4), 335-339.

Effects of nesting material on the toxicologic assessment of cyclophosphamide in Crl:CD1(ICR) mice

The provision of nesting material benefits mice by reducing cold stress, improving feed conversion, increasing litter size, and improving adaptive immunity. The effects of toxins are sensitive to environmental changes, and the introduction of novel items can alter results in...

Year Published: 2018Topics: Environmental Enrichment, Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Brochu, C. P., Winnicker, C. L., Provencher, A. L. et al. 2018. Effects of nesting material on the toxicologic assessment of cyclophosphamide in Crl:CD1(ICR) mice. JAALAS 57(4), 340-349.

Analgesic efficacy of subcutaneous–oral dosage of tramadol after surgery in C57BL/6J mice

This study investigated the analgesic activity of tramadol in female C57BL/6J mice by using a single subcutaneous injection (25 mg/kg) of tramadol combined with the same dose given in drinking water for 24 h. We then evaluated the pharmacokinetics of...

Year Published: 2018Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Evangelista-Vaz, R., Bergadano, A., Arras, M. et al. 2018. Analgesic efficacy of subcutaneous–oral dosage of tramadol after surgery in C57BL/6J mice. JAALAS 57(4), 368-375.

Comparison of serial blood collection by facial vein and retrobulbar methods in C57BL/6 mice

Many biomedical research protocols for mouse models involve serial blood collection and analysis. Two common techniques for serial blood collection in this species are the retrobulbar (RB, also called retroorbital) and facial vein (FV) methods. However, previous studies comparing these...

Year Published: 2018Topics: Biological Sampling & Physiological MeasurementAnimal Type: Mouse, Rodent

Citation: Frohlich, J. R., Alarcón, C. N., Toarmino, C. R. et al. 2018. Comparison of serial blood collection by facial vein and retrobulbar methods in C57BL/6 mice. JAALAS 57(4), 382-391.

To group or not to group? Good practice for housing male laboratory mice

It is widely recommended to group-house male laboratory mice because they are ‘social animals', but male mice do not naturally share territories and aggression can be a serious welfare problem. Even without aggression, not all animals within a group will...

Year Published: 2017Topics: Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Kappel, S., Hawkins, P., Mendl, M. 2017. To group or not to group? Good practice for housing male laboratory mice. Animals 7(12), 88.