Mouse

Refining the palpation technique to improve monitoring in the transgenic mouse

We have developed an accurate method of detecting and monitoring internal ovarian tumours. This reduces the number of procedures, refines the way we detect internal tumours and defines an end point before animals become visibly sick. The problems with the...

Year Published: 2017Topics: Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Forrest, G., Whitfield, L., Thapa, A. 2017. Refining the palpation technique to improve monitoring in the transgenic mouse. Animal Technology and Welfare 16(2), 153-154.

Report of the 2017 RSPCA/UFAW Rodent and Rabbit Welfare Group meeting

The RSPCA/UFAW Rodent (and now Rabbit) Welfare Group held a one-day meeting on 14 November 2017 in Weybridge, UK. The first session addressed meeting animals' needs and aiming for a 'good life', with the needs of female breeding rabbits as...

Year Published: 2018Topics: Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Hawkins, P., McBride, A., Paiba, G. et al. 2018. Report of the 2017 RSPCA/UFAW Rodent and Rabbit Welfare Group meeting. Animal Technology and Welfare 17(2), 75-83. [Meeting Report]

Refinement of tumour passage by optimisation of the tissue disaggregation protocol

Surgical implantation of tumour pieces has been used regularly in the passage of tumour models. This involves an invasive surgical procedure, carried out under anaesthesia, ensuring mice have adequate pain relief and peri-operative care. The procedure also requires multiple tumour-bearing...

Year Published: 2018Topics: Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Galvin, M., Lallo, A., Brown, S. et al. 2018. Refinement of tumour passage by optimisation of the tissue disaggregation protocol. Animal Technology and Welfare 17(2), 101-103.

Refining mouse handling – do we or don’t we? An animal technologist’s perspective

Recent research in the industry identified that picking up mice in a tunnel or cupping them in the hand significantly reduces their stress levels. As Animal Tecgnologists, we could see advantages and disadvantages with this change for the animals, staff...

Year Published: 2018Topics: HandlingAnimal Type: Mouse, Rodent

Citation: Swan, A. 2018. Refining mouse handling - do we or don't we? An animal technologist's perspective. Animal Technology and Welfare 17(2), 130-131.

Synchronisation of oestrous cycle on C57BL/6J mice after the introduction of a hanging perforated container with bedding soaked by the excretions of male mice

Synchronisation of oestrous cycle is a commonly used method to manage pregnancies either for breeding or for research purposes. Based on Whitten effect, the aim of our study was to introduce a new refined method for oestrous synchronisation and to...

Year Published: 2018Topics: ReproductionAnimal Type: Mouse, Rodent

Citation: Balafas, E., Stasinopoulou, M., Alexakos, P. et al. 2018. Synchronisation of oestrous cycle on C57BL/6J mice after the introduction of a hanging perforated container with bedding soaked by the excretions of male mice. Animal Technology and Welfare 17(1), 9-11.

Behavioral responses of CD-1 mice to conspecific and heterospecific blood odors and to a blood odor component

The odor of blood may have both aversive and attractive properties for mammals, depending on the species of the odor donor and the species perceiving the odor. To better understand the informational content of blood odor for a prey species...

Year Published: 2018Topics: EuthanasiaAnimal Type: Mouse, Rodent

Citation: Lahger, C., Laska, M. 2018. Behavioral responses of CD-1 mice to conspecific and heterospecific blood odors and to a blood odor component. Physiology & Behavior 184, 2015-210.

Assessing the exploratory and anxiety-related behaviors of mice

Ample studies have shown that housing can affect the health, welfare and behavior of mice and therefore, the outcomes of certain experiments. The aim of this study was to investigate if three widely used housing systems, Open Top Cages (OTC),...

Year Published: 2017Topics: Emotion, Pain, & Sentience, HousingAnimal Type: Mouse, Rodent

Citation: Polissidis, A., Zelelak, S., Nikita, M. et al. 2017. Assessing the exploratory and anxiety-related behaviors of mice. Do different caging systems affect the outcome of behavioral tests? Physiology & Behavior 177, 68-73.

A comparison of two types of running wheel in terms of mouse preference, health, and welfare

Voluntary wheel running occurs in mice of all strains, sexes, and ages. Mice find voluntary wheel running rewarding, and it leads to numerous health benefits. For this reason wheels are used both to enhance welfare and to create models of...

Year Published: 2018Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Walker, M., Mason, G. 2018. A comparison of two types of running wheel in terms of mouse preference, health, and welfare. Physiology & Behavior 191, 82-90.

The biology and husbandry of the African spiny mouse (Acomys cahirinus) and the research uses of a laboratory colony

African spiny mice (Acomysspp.) are unique precocial rodents that are found in Africa, the Middle East, and southern Asia. They exhibit several interesting life-history characteristics, including precocial development, communal breeding, and a suite of physiologic adaptations to desert life. In...

Year Published: 2016Topics: Husbandry & Management, Natural Behavior, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Haughton, C. L., Gawriluk, T. R., Seifert, A. W. 2016. The biology and husbandry of the African spiny mouse (Acomys cahirinus) and the research uses of a laboratory colony. JAALAS 55(1), 9–17.

Handling method alters the hedonic value of reward in laboratory mice

Mice are the most widely used model species for drug discovery and scientific research. Consequently, it is important to refine laboratory procedures and practices to ensure high standards of welfare and scientific data quality. Recent studies have identified that the...

Year Published: 2018Topics: HandlingAnimal Type: Mouse, Rodent

Citation: Clarkson, J. M., Dwyer, D. M., Flecknell, P. A. et al. 2019. Handling method alters the hedonic value of reward in laboratory mice. Scientific Reports 8, 2448.