Mouse

Social enrichment by separated pair housing of male C57BL/6JRj mice

Laboratory male mice are often housed individually due to aggressive behavior or experimental requirements, though social isolation can cause welfare issues. As a strategy to refine housing of male mice, we introduce the separated pair housing system. A perforated transparent...

Year Published: 2020Topics: Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Hohlbaum, K., Frahm, S., Rex, A. et al. 2020. Social enrichment by separated pair housing of male C57BL/6JRj mice. Scientific Reports 10, 11165.

A safe bet? Inter-laboratory variability in behaviour-based severity assessment

Evidence-based severity assessment is essential as a basis for ethical evaluation in animal experimentation to ensure animal welfare, legal compliance and scientific quality. To fulfil these tasks scientists, animal care and veterinary personnel need assessment tools that provide species-relevant measurements...

Year Published: 2020Topics: Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Jirkof, P., Abdelrahman, A., Bleich, A. et al. 2020. A safe bet? Inter-laboratory variability in behaviour-based severity assessment. Laboratory Animals 54(1), 73–82.

Towards a fully automated surveillance of well-being status in laboratory mice using deep learning: Starting with facial expression analysis

Assessing the well-being of an animal is hindered by the limitations of efficient communication between humans and animals. Instead of direct communication, a variety of parameters are employed to evaluate the well-being of an animal. Especially in the field of...

Year Published: 2020Topics: Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Andresen, N., Wöllhaf, M., Hohlbaum, K. et al. 2020. Towards a fully automated surveillance of well-being status in laboratory mice using deep learning: Starting with facial expression analysis. PLOS ONE 15(4), e0228059.

Welfare impact of carbon dioxide euthanasia on laboratory mice and rats: A systematic review

Background: There has been increased concern about the suitability of CO2 as a method for euthanasia of laboratory mice and rats, including the potential discomfort, pain or distress that animals may experience prior to loss of consciousness; time to loss...

Year Published: 2020Topics: EuthanasiaAnimal Type: Mouse, Rat, Rodent

Citation: Turner, P. V., Hickman, D. L., van Luijk, J. et al. 2020. Welfare impact of carbon dioxide euthanasia on laboratory mice and rats: A systematic review. Frontiers in Veterinary Science 7, 411.

What 3Rs idea have you developed?

The author describes how she used an automated system to reduce how frequently mouse cage bedding is changed without compromising cleanliness. This idea came from the desire to reduce animal stress to a minimum.

Year Published: 2020Topics: Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Filby, E. 2020. What 3Rs idea have you developed? Animal Technology and Welfare 19(1), 49-51.

Wheel running behaviour in group-housed female mice indicates disturbed wellbeing due to DSS colitis

Voluntary wheel running (VWR) behaviour is a sensitive indicator of disturbed wellbeing and used for the assessment of individual experimental severity levels in laboratory mice. However, monitoring individual VWR performance usually requires single housing, which itself might have a negative...

Year Published: 2020Topics: Disease/Experimental Model, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Weegh, N., Füner, J., Janke, O. et al. 2020. Wheel running behaviour in group-housed female mice indicates disturbed wellbeing due to DSS colitis. Laboratory Animals 54(1), 63–72.

The epidemiology of fighting in group-housed laboratory mice

Injurious home-cage aggression (fighting) in mice affects both animal welfare and scientific validity. It is arguably the most common potentially preventable morbidity in mouse facilities. Existing literature on mouse aggression almost exclusively examines territorial aggression induced by introducing a stimulus...

Year Published: 2020Topics: Abnormal/Problematic BehaviorAnimal Type: Mouse, Rodent

Citation: Theil, J. H., Ahloy-Dallaire, J., Weber, E. M. et al. 2020. The epidemiology of fighting in group-housed laboratory mice. Scientific Reports 10(1), 16649.

The impact of common recovery blood sampling methods, in mice (Mus musculus), on well-being and sample quality: A systematic review

Blood sampling is often performed in laboratory mice. Sampling techniques have the potential to cause pain, distress and impact on lifetime cumulative experience. In spite of institutions commonly providing guidance to researchers on these methods, and the existence of published...

Year Published: 2020Topics: Biological Sampling & Physiological MeasurementAnimal Type: Mouse, Rodent

Citation: Whittaker, A. L., Barker, T. H. 2020. The impact of common recovery blood sampling methods, in mice (Mus musculus), on well-being and sample quality: A systematic review. Animals 10(6), 989.

The impact of handling technique and handling frequency on laboratory mouse welfare is sex-specific

Handling is a well-known source of stress to laboratory animals and can affect variability of results and even compromise animal welfare. The conventional tail handling in mice has been shown to induce aversion and anxiety-like behaviour. Recent findings demonstrate that...

Year Published: 2020Topics: HandlingAnimal Type: Mouse, Rodent

Citation: Sensini, F., Inta, D., Palme, R. et al. 2020. The impact of handling technique and handling frequency on laboratory mouse welfare is sex-specific. Scientific Reports 10(1), 17281.

Review of intraperitoneal injection of sodium pentobarbital as a method of euthanasia in laboratory rodents

Euthanasia is one of the most commonly performed procedures in biomedical research, involving tens of millions of animals in North America and Europe every year. The use of sodium pentobarbital, injected intraperitoneally, for killing rodents is described as an acceptable...

Year Published: 2020Topics: EuthanasiaAnimal Type: Mouse, Rat, Rodent

Citation: Laferriere, C. A., Pang, D. S. 2020. Review of intraperitoneal injection of sodium pentobarbital as a method of euthanasia in laboratory rodents. JAALAS 59(3), 254–263.