Mouse

Automated monitoring of mouse feeding and body weight for continuous health assessment

Routine health assessment of laboratory rodents can be improved using automated home cage monitoring. Continuous, non-stressful, objective assessment of rodents unaware that they are being watched, including during their active dark period, reveals behavioural and physiological changes otherwise invisible to...

Year Published: 2019Topics: Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Ahloy-Dallaire, J., Klein, J. D., Davis, J. K. et al. 2019. Automated monitoring of mouse feeding and body weight for continuous health assessment. Laboratory Animals 53(4), 342–351.

Non-aversive photographic measurement method for subcutaneous tumours in nude mice

We have developed a new method for the measurement of subcutaneous tumour volume which consists in taking photographs of mice in their home cages, to refine the standard method of measurement with calipers. We consider this new method to be...

Year Published: 2019Topics: Disease/Experimental Model, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Resasco, A., Carranza Martin, A. C., Ayala, M. A. et al. 2019. Non-aversive photographic measurement method for subcutaneous tumours in nude mice. Laboratory Animals 53(4), 352–361.

Home sweet home cage

This feature describes creative ways in which technology can be used to study animals within their home cages, eliminating the need to handle, restrain, and separate them from cage mates. One example includes voluntary brain imaging in mice. In biomedical...

Year Published: 2018Topics: Imaging & Electrophysiological RecordingAnimal Type: Mouse, Rat, Rodent

Citation: Neff, E. P. 2018. Home sweet home cage. Lab Animal 47(10), 261–264.

Environmental enrichment prevents pup mortality in laboratory mice

Early death of mouse pups is a commonly known problem in breeding mice colonies, which is still often regarded as ‘normal' or is even overlooked due to the counting procedures applied. As reduced breeding performance probably indicates reduced well-being, this...

Year Published: 2019Topics: Environmental Enrichment, Rearing & WeaningAnimal Type: Mouse, Rodent

Citation: Leidinger, C. S., Thöne-Reineke, C., Baumgart, N. et al. 2019. Environmental enrichment prevents pup mortality in laboratory mice. Laboratory Animals 53(1), 53–62.

Optimal tube length of orotracheal intubation for mice

Endotracheal tube (ETT) management is an essential technique in handling mice with mechanical ventilators. Malposition into bronchi causes not only lethal complications for them but also less efficient mechanical ventilation. However, in general, it is difficult to know whether the...

Year Published: 2019Topics: Cannulation, Catheterization, & IntubationAnimal Type: Mouse, Rodent

Citation: Nosaka, N., Crother, T. R., Chen, S. et al. 2019. Optimal tube length of orotracheal intubation for mice. Laboratory Animals 53(1), 79–83.

Assessing the safety and suitability of nesting material for singly housed mice with surgically fitted head plates

Nesting material, for example shredded paper, is a common form of enrichment for laboratory mice. However, there has been limited research performed regarding its apparent safety when given to mice fitted with exteriorised devices such as head plates. Anecdotally, shredded...

Year Published: 2019Topics: Environmental Enrichment, External Bodily EquipmentAnimal Type: Mouse, Rodent

Citation: Windsor, Z., Bate, S. T. 2019. Assessing the safety and suitability of nesting material for singly housed mice with surgically fitted head plates. Heliyon 5(7), e02097.

Welfare and scientific considerations of tattooing and ear tagging for mouse identification

Ear tagging is perceived as less painful or stressful than tattooing and therefore is generally considered less harmful or costly to welfare. However, ear tags are more difficult to read than tattoos and can fall out, and mice usually require...

Year Published: 2019Topics: Identification MethodAnimal Type: Mouse, Rodent

Citation: Roughan, J. V., Sevenoaks, T. 2019. Welfare and scientific considerations of tattooing and ear tagging for mouse identification. JAALAS 58(2), 142-153.

Evaluation of a synthetic bedding substrate for mice (Mus musculus)

This study compared a synthetic bedding substrate (SBS), which has the potential to be a particulate-free animal bedding system, with the standard woodchip bedding. The objective was to demonstrate that the SBS is habitable for mice and reduces particulates to...

Year Published: 2019Topics: Housing, Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Bellin, M. A., Reitnauer, K. J., Gomez, A. M. et al. 2019. Evaluation of a synthetic bedding substrate for mice (Mus musculus). JAALAS 58(2), 154-159.

Time-dependent pathologic and inflammatory consequences of various blood sampling techniques in mice

We compared 6 frequently used mouse blood-sampling methods (lateral tail incision; tail-tip amputation; sublingual, submandibular, and saphenous vein puncture; and retrobulbar sinus puncture during isoflurane anesthesia) with regard to induction of local and systemic inflammation, stomach contents, weight changes, and...

Year Published: 2019Topics: Biological Sampling & Physiological MeasurementAnimal Type: Mouse, Rodent

Citation: Sørensen, D. B., Metzdorff, S. B., Jensen, L. K. et al. 2019. Time-dependent pathologic and inflammatory consequences of various blood sampling techniques in mice. JAALAS 58(3), 362-372.

Assessment of pain associated with the injection of sodium pentobarbital in laboratory mice (Mus musculus)

The AVMA Guidelines for the Euthanasia of Animals considers injection of barbiturates to be an acceptable method of euthanasia in rodents but states there is a potential for pain when administered intraperitoneally. This study examined the potential for pain in...

Year Published: 2019Topics: Drug/Substance Administration, EuthanasiaAnimal Type: Mouse, Rodent

Citation: Dutton III, J. W., Artwohl, J. E., Huang, X. et al. 2019. Assessment of pain associated with the injection of sodium pentobarbital in laboratory mice (Mus musculus). JAALAS 58(3), 373-379.