Mouse

Neuroinflammation, body temperature and behavioural changes in CD1 male mice undergoing acute restraint stress: An exploratory study

Background: Animal models used to study pathologies requiring rehabilitation therapy, such as cardiovascular and neurologic disorders or oncologic disease, must be as refined and translationally relevant as possible. Sometimes, however, experimental procedures such as those involving restraint may generate undesired...

Year Published: 2021Topics: Handling, RestraintAnimal Type: Mouse, Rodent

Citation: Redaelli, V., Bosi, A., Luzi, F. et al. 2021. Neuroinflammation, body temperature and behavioural changes in CD1 male mice undergoing acute restraint stress: An exploratory study. PLOS ONE 16(11), e0259938.

Attitudes of laboratory animal professionals and researchers towards carbon dioxide euthanasia for rodents and perceived barriers to change

Evidence indicates that carbon dioxide (CO2) induces negative affective states (including anxiety, fear and distress) in laboratory rodents, but many countries still accept it for euthanasia. Alternative methods (e.g. inhalant anaesthetic) may represent a refinement over CO2 but are not...

Year Published: 2021Topics: EuthanasiaAnimal Type: Mouse, Rat, Rodent

Citation: Brunt, M. W., Améndola, L., Weary, D. M. 2021. Attitudes of laboratory animal professionals and researchers towards carbon dioxide euthanasia for rodents and perceived barriers to change. Laboratory Animals 55(6), 531-539.

Grinding on a last nerve: Attempting to curb food grinding in mice

Food grinding, or chewing food without ingestion, is a topic of interest in the laboratory animal community. In addition to increased effort needed to deal with this excess waste and provide suitable microenvironment for animals, ort production in the captive...

Year Published: 2021Topics: Abnormal/Problematic Behavior, Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Garcia, T., Brown, C., Margolies, D. et al. 2021. Grinding on a last nerve: Attempting to curb food grinding in mice. Laboratory Animal Science Professional 9(6) (November/December), 34-36.

Optimal colloidal water gel type and novel placement for frequent travelers

During transportation, animals must have a water source available to prevent dehydration. Some shipping facilities use potatoes whereas, others use colloidal water gels that provide a uniform water source. The problem occurs when colloidal water gel containers are placed on...

Year Published: 2021Topics: Husbandry & Management, Relocation & TransportAnimal Type: Mouse, Rat, Rodent

Citation: Locklear, J., Whiteside, T. E. 2021. Optimal colloidal water gel type and novel placement for frequent travelers. Laboratory Animal Science Professional 9(6) (November/December), 38-40.

Replacing soiled bedding sentinel rodents with environmental health monitoring: Evidence and tips

Traditional rodent health monitoring programs involve transferring soiled bedding from colony cages to sentinel cages. While it can vary, the sentinel animals are ultimately euthanized after 3-6 mo of soiled bedding exposure. Using traditional soiled bedding sentinel rodents has several...

Year Published: 2021Topics: Husbandry & ManagementAnimal Type: Mouse, Rat, Rodent

Citation: LaFollette, M. R., Cunningham-Faughnan, T., Foley, P. L. et al. 2021. Replacing soiled bedding sentinel rodents with environmental health monitoring: Evidence and tips. Laboratory Animal Science Professional 9(6) (November/December), 46-48.

Exploring refinement strategies for single housing of male C57BL/6JRj mice: Effect of cage divider on stress-related behavior and hypothalamic-pituitary-adrenal-axis activity

Introduction: Single housing of laboratory mice is a common practice to meet experimental needs, or to avoid intermale aggression. However, single housing is considered to negatively affect animal welfare and may compromise the scientific validity of experiments. The aim of...

Year Published: 2021Topics: Environmental Enrichment, Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Buckinx, A., Van Schuerbeek, A., Bossuyt, J. et al. 2021. Exploring refinement strategies for single housing of male C57BL/6JRj mice: Effect of cage divider on stress-related behavior and hypothalamic-pituitary-adrenal-axis activity. Frontiers in Behavioral Neuroscience 15, 743959.

Can animals develop depression? An overview and assessment of “depression-like” states

Describing certain animal behaviours as 'depression-like' or 'depressive' has become common across several fields of research. These typically involve unusually low activity or unresponsiveness and/or reduced interest in pleasure (anhedonia). While the term 'depression-like' carefully avoids directly claiming that animals...

Year Published: 2021Topics: Emotion, Pain, & SentienceAnimal Type: Bird, Cattle, Chicken, Dog, Equine, Fowl, Macaque, Mouse, Nonhuman Primate, Pig, Rat, Rodent

Citation: MacLellan, A., Fureix, C., Polanco, A. et al. 2021. Can animals develop depression? An overview and assessment of “depression-like” states. Behaviour 158(14/15), 1303–1353.

Exploring refinement strategies for single housing of male C57BL/6JRj mice: Effect of cage divider on stress-related behavior and hypothalamic-pituitary-adrenal-axis activity

Year Published: 2021Topics: Environmental Enrichment, Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Distress analysis of mice with cervical arteriovenous fistulas

The welfare of laboratory animals is a consistent concern for researchers. Its evaluation not only fosters ethical responsibility and addresses legal requirements, but also provides a solid basis for a high quality of research. Recently, a new cervical arteriovenous model...

Year Published: 2021Topics: Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Xie, W., Palme, R., Schafmayer, C. et al. 2021. Distress analysis of mice with cervical arteriovenous fistulas. Animals 11(11), 3051.

Enriched laboratory housing increases sensitivity to social stress in female California mice (Peromyscus californicus)

Domesticated mice and rats have shown to be powerful model systems for biomedical research, but there are cases in which the biology of species is a poor match for the hypotheses under study. The California mouse (Peromyscus californicus) has unique...

Year Published: 2021Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Minie, V. A., Petric, R., Ramos-Maciel, S. et al. 2021. Enriched laboratory housing increases sensitivity to social stress in female California mice (Peromyscus californicus). Applied Animal Behaviour Science 241, 105381.