Mouse

Why does lifelong conventional housing reduce the sociability of female mice?

Compared to peers raised in well-resourced, 'enriched' environments (‘EE'), female laboratory mice from conventional barren cages are more aggressive to their cage-mates, and less sociable with familiar non-cage-mates (especially if these too are from conventional housing, ‘CH'). But how do...

Year Published: 2022Topics: Housing, Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Kitchenham, L., Nazal, B., Adcock, A. et al. 2022. Why does lifelong conventional housing reduce the sociability of female mice? Applied Animal Behaviour Science 246, 105532.

Effects of multimodal analgesic protocol, with buprenorphine and meloxicam, on mice well-being: A dose finding study

The anesthetic or analgesic agent of choice, route and frequency of anesthetic or analgesic administration, and stressors induce distress during the perioperative period. We evaluated a multimodal analgesic protocol using buprenorphine and meloxicam on the well-being of mice. Twenty-four Slc:ICR...

Year Published: 2021Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Furumoto, K., Ogita, K., Kamisaka, T. et al. 2021. Effects of multimodal analgesic protocol, with buprenorphine and meloxicam, on mice well-being: A dose finding study. Animals 11(12), 3420.

Welfare assessment, end-point refinement and the effects of non-aversive handling in C57BL/6 mice with Lewis lung cancer

Cancer-bearing mice are at risk of developing anxiety, pain, or malaise. These conditions may not only harm welfare but could also undermine data quality and translational validity in studies to develop therapeutic interventions. We aimed to establish whether, or at...

Year Published: 2021Topics: Disease/Experimental Model, Humane Endpoint, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Miller, A. L., Roughan, J. V. 2021. Welfare assessment, end-point refinement and the effects of non-aversive handling in C57BL/6 mice with Lewis lung cancer. Animals 12(1), 23.

Non-invasive assessment of mild stress-induced hyperthermia by infrared thermography in laboratory mice

Stress-induced hyperthermia (SIH) is a physiological response to acute stressors in mammals, shown as an increase in core body temperature, with redirection of blood flow from the periphery to vital organs. Typical temperature assessment methods for rodents are invasive and...

Year Published: 2022Topics: Biological Sampling & Physiological MeasurementAnimal Type: Mouse, Rodent

Citation: Blenkuš, U., Gerós, A. F., Carpinteiro, C. et al. 2022. Non-invasive assessment of mild stress-induced hyperthermia by infrared thermography in laboratory mice. Animals 12(2), 177.

Automated monitoring of respiratory rate as a novel humane endpoint: A refinement in mouse metastatic lung cancer models

In oncology research, while xenograft tumor models are easily visualized and humane endpoints can be clearly defined, metastatic tumor models are often based on more subjective clinical observations as endpoints. This study aimed at identifying objective non-invasive criteria for predicting...

Year Published: 2021Topics: Disease/Experimental Model, Humane EndpointAnimal Type: Mouse, Rodent

Citation: Winn, C. B., Hwang, S. K., Morin, J. et al. 2021. Automated monitoring of respiratory rate as a novel humane endpoint: A refinement in mouse metastatic lung cancer models. PLOS ONE 16(9), e0257694.

Are female mice dehydrated during peak lactation? Effect of water and gel supplement on hydration parameters and water consumption in two strains of mice

Mice (Mus musculus) have a high basal rate of metabolism which increases during pregnancy and lactation. During peak lactation, water intake amounts to up to 65 % of the bodyweight per day. Providing water in a bottle may pose a...

Year Published: 2021Topics: Husbandry & Management, Rearing & WeaningAnimal Type: Mouse, Rodent

Citation: Grims, C., Jacobson, C., Hedenqvist, P. 2021. Are female mice dehydrated during peak lactation? Effect of water and gel supplement on hydration parameters and water consumption in two strains of mice. Scandinavian Journal of Laboratory Animal Science 47(3), 16-24.

Using cage ladders as a handling device reduces aversion and anxiety in laboratory mice, similar to tunnel handling

Handling laboratory animals for husbandry and other procedures can be an important source of anxiety and stress, compromising animal welfare as well as the reliability of research that is sensitive to background stressors. Studies have revealed that picking up laboratory...

Year Published: 2021Topics: HandlingAnimal Type: Mouse, Rodent

Citation: Sandgren, R., Grims, C., Waters, J. et al. 2021. Using cage ladders as a handling device reduces aversion and anxiety in laboratory mice, similar to tunnel handling. Scandinavian Journal of Laboratory Animal Science 47(5), 31-41.

Using approach latency and anticipatory behaviour to assess whether voluntary playpen access is rewarding to laboratory mice

Laboratory mice are typically housed in "shoebox" cages that limit the expression of natural behaviours. Temporary access to more complex environments (playpens) may improve their welfare. We aimed to assess if access to playpens is rewarding for conventionally-housed mice and...

Year Published: 2021Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Ratuski, A. S., Makowska, I. J., Dvorack, K. R. et al. 2021. Using approach latency and anticipatory behaviour to assess whether voluntary playpen access is rewarding to laboratory mice. Scientific Reports 11(1), 18683.

Mice prefer draught-free housing

An increasing number of rodents are housed in individually ventilated cage (IVC) systems, as these seem to be very effective for the protection of animals against infections, as well as protecting the staff against allergens. For the IVC systems to...

Year Published: 2010Topics: Housing, Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Krohn, T. C., Hansen, A. K. 2010. Mice prefer draught-free housing. Laboratory Animals 44(4), 370-372.

Housing breeding mice in three different IVC systems: Maternal performance and pup development

A proper cage environment is essential for the welfare of laboratory mice, especially for females during the energy demanding lactation period and for pups during early development and growth. The most common housing system for laboratory mice is individually ventilated...

Year Published: 2014Topics: Housing, Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Spangenberg, E., Wallenbeck, A., Eklöf, A.-C. et al. 2014. Housing breeding mice in three different IVC systems: Maternal performance and pup development. Laboratory Animals 48(3), 193–206.