Mouse

Roaming in a land of milk and honey: Life trajectories and metabolic rate of female inbred mice living in a semi naturalistic environment

Despite tremendous efforts at standardization, the results of scientific studies can vary greatly, especially when considering animal research. It is important to emphasize that consistent different personality-like traits emerge and accumulate over time in laboratory mice despite genetic and environmental...

Year Published: 2021Topics: HousingAnimal Type: Mouse, Rodent

Citation: Mieske, P., Diederich, K., Lewejohann, L. 2021. Roaming in a land of milk and honey: Life trajectories and metabolic rate of female inbred mice living in a semi naturalistic environment. Animals 11(10), 3002.

Refining procedures within regulatory toxicology studies: Improving animal welfare and data

During the development of potential new medicines or agrochemicals, an assessment of the safety profile to humans and environmental species is conducted using a range of different in silico and in vitro techniques in conjunction with metabolism and toxicity studies...

Year Published: 2021Topics: Biological Sampling & Physiological Measurement, Cannulation, Catheterization, & Intubation, HousingAnimal Type: Dog, Fish, Mouse, Nonhuman Primate, Pig, Rabbit, Rat, Rodent

Citation: Prior, H., Blunt, H., Crossman, L. et al. 2021. Refining procedures within regulatory toxicology studies: Improving animal welfare and data. Animals 11(11), 3057.

Refinements in head plate mouse nesting: Using composite nests to enhance welfare

When given the opportunity, mice will choose to build nests using multiple different materials. Studies indicate that providing mice with choices which mimic the natural environment allows laboratory mice to build the best quality nests and mice have also been...

Year Published: 2021Topics: Environmental Enrichment, External Bodily EquipmentAnimal Type: Mouse, Rodent

Citation: Windsor, Z. 2021. Refinements in head plate mouse nesting: Using composite nests to enhance welfare. Animal Technology and Welfare 20(2), 135-141.

Thinking outside of the tunnel for non-aversive mouse handling

The key to non-aversive methods of handling lies in understanding what capture method creates the least anxiety in mice: be this tunnel or cupping or another method. It is important that we do not get so focussed on tunnel handling,...

Year Published: 2021Topics: HandlingAnimal Type: Mouse, Rodent

Citation: Moore, J., Wickert, M. 2021. Thinking outside of the tunnel for non-aversive mouse handling. Animal Technology and Welfare 20(2), 161-163.

A tunnel is not enough: Mice benefit from in-cage provision of a communal shelter as well as a handling tunnel

Mouse shelters can provide mice with security, help them thermoregulate, offer darkness to prevent damage to their eyes and enable climbing and gnawing opportunities. For laboratory mice, there is a vast array of commercially available cage furniture, so choosing which...

Year Published: 2021Topics: Environmental Enrichment, HousingAnimal Type: Mouse, Rodent

Citation: Burn, C. C., Popat, R. 2021. A tunnel is not enough: Mice benefit from in-cage provision of a communal shelter as well as a handling tunnel. Animal Technology and Welfare 20(3), 203-210.

Maximising efficacy of your health monitoring programme

There are a multitude of health monitoring techniques/ methods available. It can be difficult to know which of these to use and when to use them. This is an attempt to simplify, maximise the efficacy of and ultimately reduce the...

Year Published: 2021Topics: Husbandry & ManagementAnimal Type: Chinchilla, Gerbil, Guinea Pig, Hamster, Mouse, Rat, Rodent

Citation: Dickinson, A. 2021. Maximising efficacy of your health monitoring programme. Animal Technology and Welfare 20(3), 255-257.

An examination of nest-building behaviour using five different nesting materials in C57BL/6J and BALB/c mice

The aim of our study was to assess the nest-building behaviour of two mouse (Mus musculus) strains using different nesting materials and examine possible sex- and housing-specific effects. Adult mice of two strains (C57BL/6J; n = 64 and BALB/cAnNCrl; n...

Year Published: 2021Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Obermueller, B., Castellani, C., Till, H. et al. 2021. An examination of nest-building behaviour using five different nesting materials in C57BL/6J and BALB/c mice. Animal Welfare 30(4), 467-477.

Diagnostic ability of methods depicting distress of tumor-bearing mice

Subcutaneous tumor models in mice are the most commonly used experimental animal models in cancer research. To improve animal welfare and the quality of scientific studies, the distress of experimental animals needs to be minimized. For this purpose, one must...

Year Published: 2021Topics: Disease/Experimental Model, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Xie, W., Kordt, M., Palme, R. et al. 2021. Diagnostic ability of methods depicting distress of tumor-bearing mice. Animals 11(8), 2155.

All the pups we cannot see: Cannibalism masks perinatal death in laboratory mouse breeding but infanticide is rare

Perinatal mortality is a major issue in laboratory mouse breeding. We compared a counting method using daily checks (DAILY_CHECK) with a method combining daily checks with detailed video analyses to detect cannibalisms (VIDEO_TRACK) for estimating the number of C57BL/6 pups...

Year Published: 2021Topics: Rearing & WeaningAnimal Type: Mouse, Rodent

Citation: Brajon, S., Morello, G. M., Capas-Peneda, S. et al. 2021. All the pups we cannot see: Cannibalism masks perinatal death in laboratory mouse breeding but infanticide is rare. Animals 11(8), 2327.

Voluntary oral administration of drugs in mice

Oral administration of substances is a common procedure in scientific experiments using laboratory animals and typically is achieved in conscious animals by using the intragastric gavage technique. While highly effective, this method can be technically challenging particularly in small animals...

Year Published: 2011Topics: Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Zhang, L. 2011. Voluntary oral administration of drugs in mice. Protocol Exchange [version 1, protocol preprint].