Mouse

Green clay: Not just for a pretty face

Mice can be prone to skin lesions for various reasons. Green clay is a non-invvasive method to treat such skin lesions, and does not require veterinary approval or have properties that may interfere with an experiment. Green clay is ost...

Year Published: 2022Topics: Abnormal/Problematic Behavior, Analgesia, Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Bissmire, H. 2022. Green clay: Not just for a pretty face. Animal Technology and Welfare 21(3), 242–243.

Tetra-primer amplification-refractory mutationsystem (ARMS)—PCR for genotyping mouse leptin gene mutation

Due to spontaneous deficiency in leptin, ob/ob mice are one of the most commonly used experimental animal models in diabetes research. In this study, we reported a quick and easy-to-conduct genotyping method using tetra-primer amplification refractory mutation system-polymerase chain reaction...

Year Published: 2022Topics: Disease/Experimental Model, Identification MethodAnimal Type: Mouse, Rodent

Citation: Chen, J., Xu, X., Dalhaimer, P. et al. 2022. Tetra-primer amplification-refractory mutationsystem (ARMS)—PCR for genotyping mouse leptin gene mutation. Animals 12(19), 2680.

Impact of partial bile duct ligation with or without repeated magnetic resonance imaging examinations in mice

Partial bile duct ligation (pBDL) is considered a well-tolerated cholestatic model. Magnetic resonance imaging (MRI) is one of the most widely used tools in noninvasive imaging. However, no systematic studies have reported the possible effects of repeated MRI assessments in...

Year Published: 2022Topics: Disease/Experimental Model, Imaging & Electrophysiological RecordingAnimal Type: Mouse, Rodent

Citation: Chen, T., Zhou, Z.-Y., Liu, J.-Y. et al. 2022. Impact of partial bile duct ligation with or without repeated magnetic resonance imaging examinations in mice. Scientific Reports 12(1), 21014.

Review of rat (Rattus norvegicus), Mouse (Mus musculus), Guinea pig (Cavia procellus), and rabbit (Oryctolagus cuniculus) indicators for welfare assessment

The monitoring and assessment of animals is important for their health and welfare. The appropriate selection of multiple, validated, and feasible welfare assessment indicators is required to effectively identify compromises or improvements to animal welfare. Animal welfare indicators can be...

Year Published: 2023Topics: Welfare AssessmentAnimal Type: Guinea Pig, Mouse, Rabbit, Rat, Rodent

Citation: Cohen, S., Ho, C. 2023. Review of rat (Rattus norvegicus), Mouse (Mus musculus), Guinea pig (Cavia procellus), and rabbit (Oryctolagus cuniculus) indicators for welfare assessment. Animals 13(13), 2167.

Handling method affects measures of anxiety, but not chronic stress in mice

Studies in mice have shown that less aversive handling methods (e.g. tunnel or cup handling) can reduce behavioural measures of anxiety in comparison to picking mice up by their tail. Despite such evidence, tail handling continues to be used routinely....

Year Published: 2022Topics: Emotion, Pain, & Sentience, HandlingAnimal Type: Mouse, Rodent

Citation: Novak, J., Jaric, I., Rosso, M. et al. 2022. Handling method affects measures of anxiety, but not chronic stress in mice. Scientific Reports 12(1), 20938.

3D-printed lightweight dorsal skin fold chambers from PEEK reduce chamber-related animal distress

The dorsal skinfold chamber is one of the most important in vivo models for repetitive longitudinal assessment of microcirculation and inflammation. This study aimed to refine this model by introducing a new lightweight chamber made from polyetheretherketone (PEEK). Body weight,...

Year Published: 2022Topics: External Bodily EquipmentAnimal Type: Mouse, Rodent

Citation: Xie, W., Lorenz, M., Poosch, F. et al. 2022. 3D-printed lightweight dorsal skin fold chambers from PEEK reduce chamber-related animal distress. Scientific Reports 12(1), 11599.

The prevention of home-cage grid climbing affects muscle strength in mice

Experimenters and treatment methods are the major contributors to data variability in behavioral neuroscience. However, home cage characteristics are likely associated with data variability. Mice housed in breeding cages spontaneously exhibit behavioral patterns such as biting into the wire grid...

Year Published: 2022Topics: HousingAnimal Type: Mouse, Rodent

Citation: Ueno, H., Takahashi, Y., Murakami, S. et al. 2022. The prevention of home-cage grid climbing affects muscle strength in mice. Scientific Reports 12(1), 15263.

Post mortem study on the effects of routine handling and manipulation of laboratory mice

Routine handling and manipulation of laboratory mice are integral components of most preclinical studies. Any type of handling and manipulation may cause stress and result in physical harm to mice, potentially leading to unintended consequences of experimental outcomes. Nevertheless, the...

Year Published: 2022Topics: HandlingAnimal Type: Mouse, Rodent

Citation: Assenmacher, C.-A., Lanza, M., Tarrant, J. C. et al. 2022. Post mortem study on the effects of routine handling and manipulation of laboratory mice. Animals 12(23), 3234.

Longitudinal home-cage automated assessment of climbing behavior shows sexual dimorphism and aging-related decrease in C57BL/6J healthy mice and allows early detection of motor impairment in the N171-82Q mouse model of Huntington’s disease

Monitoring the activity of mice within their home cage is proving to be a powerful tool for revealing subtle and early-onset phenotypes in mouse models. Video-tracking, in particular, lends itself to automated machine-learning technologies that have the potential to improve...

Year Published: 2023Topics: Behavioral & Cognitive Testing, Disease/Experimental Model, HandlingAnimal Type: Mouse, Rodent

Citation: Bains, R. S., Forrest, H., Sillito, R. R. et al. 2023. Longitudinal home-cage automated assessment of climbing behavior shows sexual dimorphism and aging-related decrease in C57BL/6J healthy mice and allows early detection of motor impairment in the N171-82Q mouse model of Huntington's disease. Frontiers in Behavioral Neuroscience 17, 1148172.

A review of methods used to kill laboratory rodents: Issues and opportunities

Rodents are the most widely used species for scientific purposes. A critical pre-requisite of their use, based on utilitarian ethical reasoning, is the provision of a humane death when necessary for scientific or welfare grounds. Focussing on the welfare challenges...

Year Published: 2022Topics: EuthanasiaAnimal Type: Mouse, Rat, Rodent

Citation: Clarkson, J. M., Martin, J. E., McKeegan, D. E. F. 2022. A review of methods used to kill laboratory rodents: Issues and opportunities. Laboratory Animals 56(5), 419-436.