Mouse

Simultaneous assessment of spontaneous cage activity and voluntary wheel running in group-housed mice

Small animal models are frequently used to improve our understanding of the molecular and biological signaling pathways underlying the beneficial effects of physical activity and exercise. Unfortunately, when running wheels are employed, mice and rats are often kept single-housed to...

Year Published: 2022Topics: Behavioral & Cognitive TestingAnimal Type: Mouse, Rodent

Citation: Reuser, A., Wenzel, K., Felix, S. B. et al. 2022. Simultaneous assessment of spontaneous cage activity and voluntary wheel running in group-housed mice. Scientific Reports 12(1), 4444.

Report of the 2021 RSPCA/UFAW Rodent Welfare Group meeting

The RSPCA/UFAW Rodent Welfare Group has held a one-day meeting every autumn for the last 28 years, so that its members can discuss current welfare research, exchange views on welfare issues and share experiences of the implementation of the 3Rs...

Year Published: 2022Topics: Environmental Enrichment, Husbandry & ManagementAnimal Type: Mouse, Rat, Rodent

Citation: Stevens, C., Dobbinson, K., Brook, E. et al. 2022. Report of the 2021 RSPCA/UFAW Rodent Welfare Group meeting. Animal Technology and Welfare 21(2), 83-91.

Refinement of handling and dosing methods for rats and mice

Modified Handling for Mice: Handling mice by gripping the base of the tail has been shown to negatively impact animal welfare by increasing anxiety and aversion to handling. We aimed to refi ne the dosing procedure by finding a handling...

Year Published: 2022Topics: Drug/Substance Administration, HandlingAnimal Type: Mouse, Rat, Rodent

Citation: Bartlett, J., Davies, J., Purawijaya, D. et al. 2022. Refinement of handling and dosing methods for rats and mice. Animal Technology and Welfare 21(2), 120-124.

Medicated jelly as a replacement for injectables and the use of Maropitant to manage itchy skin in mice

It is desirable to administer drugs by the least invasive route to (1) optimise welfare, (2) reduce the risk of injury to animal handlers and (3) minimise the impact of restraint and transient pain on physiological and experimental readouts. Bio-Serv®...

Year Published: 2022Topics: Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Donaldson-Wing, M. 2022. Medicated jelly as a replacement for injectables and the use of Maropitant to manage itchy skin in mice. Animal Technology and Welfare 21(2), 134-136.

Effects of non-aversive versus tail-lift handling on breeding productivity in a C57BL/6J mouse colony

Non-aversive handling is a well-documented refinement measure for improving rodent welfare. Because maternal stress is related to reduced productivity, we hypothesized that welfare benefits associated with non-aversive handling would translate to higher production and fewer litters lost in a laboratory...

Year Published: 2022Topics: HandlingAnimal Type: Mouse, Rodent

Citation: Hull, M. A., Reynolds, P. S., Nunamaker, E. A. 2022. Effects of non-aversive versus tail-lift handling on breeding productivity in a C57BL/6J mouse colony. PLOS ONE 17(1), e0263192.

Voluntary wheel running behaviour as a tool to assess the severity in a mouse pancreatic cancer model

Laboratory animals frequently undergo routine experimental procedures such as handling, restraining and injections. However, as a known source of stress, these procedures potentially impact study outcome and data quality. In the present study, we, therefore, performed an evidence-based severity assessment...

Year Published: 2021Topics: Disease/Experimental Model, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Weegh, N., Zentrich, E., Zechner, D. et al. 2021. Voluntary wheel running behaviour as a tool to assess the severity in a mouse pancreatic cancer model. PLOS ONE 16(12), e0261662.

Refined ways to pick up mice

As part of our commitment to continuous improvement of laboratory animal welfare, the North American 3Rs Collaborative (NA3RsC) brought together several experts to examine the evidence, impact, and practicality of alternative methods for picking up mice.

Year Published: 2022Topics: HandlingAnimal Type: Mouse, Rodent

Citation: LaFollette, M. R. 2022. Refined ways to pick up mice. Laboratory Animal Science Professional 10(2) (March/April), 46-48.

A new feeder device to provide cleaner and accessible diet gel to laboratory mice

Gel solutions are simple to use, have a relative long shelf life and can be delivered with plastic cups or pouches. A common issue encountered by many institutions is that the gel becomes soiled quickly due to multiple factors such...

Year Published: 2022Topics: Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Scorrano, F. 2022. A new feeder device to provide cleaner and accessible diet gel to laboratory mice. Laboratory Animal Science Professional 10(2) (March/April), 50-52.

Effects of hair removal creams on mouse skin

Human hair removal brands such as Nair™ are sometimes used in research to remove hair from mice before surgery, imaging, and other procedures.1,3 While the use of these depilatory creams in rodent research is relatively widespread, few studies have evaluated...

Year Published: 2022Topics: Surgery & Post-OpAnimal Type: Mouse, Rodent

Citation: Reichert, M., Koewler, N., Hargis, A. M. et al. 2022. Effects of hair removal creams on mouse skin. Laboratory Animal Science Professional 10(3) (May/June), 46-47.

Social buffering as a tool for improving rodent welfare

The presence of a conspecific can be calming to some species of animal during stress, a phenomenon known as social buffering. For rodents, social buffering can reduce the perception of and reaction to aversive experiences. With a companion, animals may...

Year Published: 2022Topics: Social Housing & CompanionshipAnimal Type: Mouse, Rat, Rodent

Citation: Denommé, M. R., Mason, G. J. 2022. Social buffering as a tool for improving rodent welfare. JAALAS 61(1), 5-14.