Mouse

Thirty years of telemetry-based data acquisition for cardiovascular drug safety evaluation: Applications and optimization

Conducting safety evaluations of new drugs using conscious animals has been a specialty of our working group for thirty years. In this article, we review the various technical challenges and solutions dealt with over the years to improve both the...

Year Published: 2023Topics: Biological Sampling & Physiological Measurement, External Bodily EquipmentAnimal Type: Dog, Guinea Pig, Macaque, Mouse, Nonhuman Primate, Pig, Rat, Rodent

Citation: Alizadeh, E. A., Graf, K., Schiwon, J. et al. 2023. Thirty years of telemetry-based data acquisition for cardiovascular drug safety evaluation: Applications and optimization. Journal of Pharmacological and Toxicological Methods 122, 107279.

Why all healthy laboratory animals should be rehomed, no matter how small

This paper explores the ethical imperative of rehoming all healthy animals of sentient species after experiments have finished or when they have become otherwise redundant. We take into account disparate perspectives in animal ethics and see how they point in...

Year Published: 2023Topics: Regulations & Ethical ReviewAnimal Type: All/General, Mouse, Rat, Rodent

Citation: Van Loo, P. L. P., Janssens, M. R. E. 2023. Why all healthy laboratory animals should be rehomed, no matter how small. Animals 13(17), 2727.

More exploratory house mice judge an ambiguous situation more negatively

Exploration tendency, one of the most investigated animal personality traits, may be driven by either positive (when seeking interesting information) or negative (to reduce the uncertainty of the environment) affective/emotional profiles. To disentangle the valence of the affective state associated...

Year Published: 2021Topics: Emotion, Pain, & Sentience, PersonalityAnimal Type: Mouse, Rodent

Citation: Verjat, A., Devienne, P., Rödel, H. G. et al. 2021. More exploratory house mice judge an ambiguous situation more negatively. Animal Cognition 24(1), 53–64.

Reduction in cold stress in an innovative metabolic cage housing system increases animal welfare in laboratory mice

Housing in metabolic cages can induce a pronounced stress response. Metabolic cage systems imply housing mice on metal wire mesh for the collection of urine and feces in addition to monitoring food and water intake. Moreover, mice are single-housed, and...

Year Published: 2023Topics: Housing, Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Wittek, L., Touma, C., Nitezki, T. et al. 2023. Reduction in cold stress in an innovative metabolic cage housing system increases animal welfare in laboratory mice. Animals 13(18), 2866.

A novel dental caries model replacing, refining, and reducing animal sacrifice

In vitro and in vivo models simulating the dental caries process enable the evaluation of anti-caries modalities for prevention and treatment. Animal experimentation remains important for improving human and animal health. Nonetheless, reducing animal sacrifice for research is desirable. The...

Year Published: 2021Topics: Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Wolfoviz-Zilberman, A., Houri-Haddad, Y., Beyth, N. 2021. A novel dental caries model replacing, refining, and reducing animal sacrifice. Applied Sciences 11(15), 7141.

The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals (9th ed.)

The latest edition of the seminal reference on the care and management of laboratory and research animals. The newly revised ninth edition of The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals delivers an up-to-date...

Year Published: 2024Topics: Animal Training, Environmental Enrichment, Euthanasia, Housing, Husbandry & Management, Natural Behavior, Relocation & Transport, Welfare AssessmentAnimal Type: Amphibian, Bird, Capuchin, Cat, Cattle, Cephalopod, Crustacean, Dog, Equine, Ferret, Finch, Fish, Fowl, Frog & Toad, Gerbil, Goat, Guinea Pig, Hamster, Invertebrate, Lizard, Macaque, Marmoset, Mole Rat, Mouse, Nonhuman Primate, Other Animal, Other Bird, Other Fish, Other Nonhuman Primate, Other Rodent, Pig, Rabbit, Rat, Reptile, Rodent, Sheep, Snake, Tree Shrew, Turtle & Tortoise, Vervet (African Green Monkey), Zebrafish

Citation: Golledge, H., Richardson, C. (Eds.) 2024. The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals (9th ed.). Wiley-Blackwell. 1040 p.

Mice prone to tinnitus after acoustic trauma show increased pre-exposure sensitivity to background noise

Noise-induced tinnitus is generally associated with hearing impairment caused by traumatic acoustic overexposure. Previous studies in laboratory animals and human subjects, however, have observed differences in tinnitus susceptibility, even among individuals with similar hearing loss. The mechanisms underlying increased sensitivity...

Year Published: 2023Topics: Behavioral & Cognitive TestingAnimal Type: Mouse, Rodent

Citation: Rybalko, N., Suchánková, Š., Bureš, Z. et al. 2023. Mice prone to tinnitus after acoustic trauma show increased pre-exposure sensitivity to background noise. Frontiers in Behavioral Neuroscience 17.

Report of the 2022 RSPCA/UFAW Rodent Welfare Group Meeting

The RSPCA/UFAW Rodent Welfare Group has held a one-day meeting every autumn for the last 29 years, so that its members can discuss current welfare research, exchange views on welfare issues and share experiences of the implementation of the 3Rs...

Year Published: 2023Topics: Emotion, Pain, & Sentience, Environmental Enrichment, Euthanasia, HandlingAnimal Type: Mouse, Other Rodent, Rat, Rodent

Citation: Stevens, C., Hammonds, T., Hinchcliffe, J. et al. 2023. Report of the 2022 RSPCA/UFAW Rodent Welfare Group Meeting. Animal Technology and Welfare 22(2), 91–100.

Classification of multiple emotional states from facial expressions in head-fixed mice using a deep learning-based image analysis

Facial expressions are widely recognized as universal indicators of underlying internal states in most species of animals, thereby presenting as a non-invasive measure for assessing physical and mental conditions. Despite the advancement of artificial intelligence-assisted tools for automated analysis of...

Year Published: 2023Topics: Emotion, Pain, & Sentience, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Tanaka, Y., Nakata, T., Hibino, H. et al. 2023. Classification of multiple emotional states from facial expressions in head-fixed mice using a deep learning-based image analysis. PLOS ONE 18(7), e0288930.

Refining stereotaxic neurosurgery techniques and welfare assessment for long-term intracerebroventricular device implantation in rodents

Stereotaxic surgeries enable precise access to specific brain regions, being of particular interest for chronic intracerebroventricular drug delivery. However, the challenge of long-term studies at this level is to allow the implantation of drug storage devices and their correct intrathecal...

Year Published: 2023Topics: External Bodily EquipmentAnimal Type: Mouse, Rodent

Citation: Pérez-Martín, E., Coto-Vilcapoma, A., Castilla-Silgado, J. et al. 2023. Refining stereotaxic neurosurgery techniques and welfare assessment for long-term intracerebroventricular device implantation in rodents. Animals 13(16), 2627.