Mouse

Euthanasia of neonatal rats and mice using carbon monoxide

Minimization of potential pain and distress of rodents undergoing euthanasia is a touchstone of veterinary clinical medicine. Evaluation of this issue in postweanling rodents has supported revisions to the AVMA (American Veterinary Medical Association) Guidelines on Euthanasia in 2020. However,...

Year Published: 2023Topics: EuthanasiaAnimal Type: Mouse, Rat, Rodent

Citation: Hickman, D. L. 2023. Euthanasia of neonatal rats and mice using carbon monoxide. JAALAS 62(3), 274–278.

Effects of isoflurane anesthesia on C57BL/6J pups after cervical dislocation of dams

Inhalant anesthesia is routinely used for cesarian section in many animal species, allowing the safe delivery of neonates and smooth recovery of dams. However, in mice, inhalant anesthesia in cesarean section may be avoided due to fear of negative health...

Year Published: 2023Topics: ReproductionAnimal Type: Mouse, Rodent

Citation: Hunter, C. L., Yang, P., Renner, D. M. et al. 2023. Effects of isoflurane anesthesia on C57BL/6J pups after cervical dislocation of dams. JAALAS 62(5), 449–452.

A review of long-acting parenteral analgesics for mice and rats

Appropriate analgesia is a crucial part of rodent postoperative and postprocedural pain. Providing appropriate analgesia is an ethical obligation, a regulatory requirement, and an essential element of obtaining quality scientific results and conducting reproducible data. Meeting these requirements is facilitated...

Year Published: 2022Topics: Anesthesia & SedationAnimal Type: Mouse, Rat, Rodent

Citation: Huss, M. K., Pacharinsak, C. 2022. A review of long-acting parenteral analgesics for mice and rats. JAALAS 61(6), 595–602.

Comparative pharmacokinetics and injection site histopathology in nude mice treated with long-acting buprenorphine formulations

Two long-acting formulations of buprenorphine are commercially available as analgesics for rodents. However, these drugs have not yet been studied in nude mice. We sought to investigate whether the manufacturer-recommended or labeled mouse doses of either drug would provide and...

Year Published: 2023Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Illario, J. A., Osborn, K. G., Garcia, A. V. et al. 2023. Comparative pharmacokinetics and injection site histopathology in nude mice treated with long-acting buprenorphine formulations. JAALAS 62(2), 147–152.

Evaluation and refinement of a spot-change–only cage management system for mice

Maximizing operational efficiency while maintaining appropriate animal housing conditions is a continuous focus of research animal care programs. Our institution's longstanding approach to cage-change management included scheduled cage changes every 2 wk, with spot changes if cages met established visual...

Year Published: 2022Topics: Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Jones, T., Thaweethai, T., Molk, D. et al. 2022. Evaluation and refinement of a spot-change–only cage management system for mice. JAALAS 61(6), 650–659.

High-dose meloxicam provides improved analgesia in female CD1 mice: A pharmacokinetic and efficacy study

Meloxicam is a nonsteroidal anti-inflammatory analgesic drug that is often used in mice. However, doses of 1 to 5 mg/kg given twice daily were recently reported to provide inadequate analgesia. Some studies suggest that doses of up to 20 mg/kg...

Year Published: 2023Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Kim, J., Cannon, B. A., Freeman, L. E. et al. 2023. High-dose meloxicam provides improved analgesia in female CD1 mice: A pharmacokinetic and efficacy study. JAALAS 62(1), 74–80.

Benchmarking enrichment efforts in the US & Canada across species and enrichment categories

Enrichment is important for animal welfare and data quality. Provision of enrichment opportunities varies between species and enrichment category. However, data benchmarking these differences does not exist. Our objective was to characterize enrichment provision and associated factors across species in...

Year Published: 2023Topics: Environmental EnrichmentAnimal Type: Cat, Cattle, Chicken, Dog, Ferret, Goat, Macaque, Mink, Mouse, Nonhuman Primate, Rabbit, Rat, Rodent, Sheep

Citation: LaFollette, M. R., Cloutier, S., Brady, C. M. et al. 2023. Benchmarking enrichment efforts in the US & Canada across species and enrichment categories. JAALAS 62(4), 303–316.

Perinatal environmental enrichment changes anxiety-like behaviours in mice and produces similar intergenerational benefits in offspring

Environmental enrichment implemented in early life is able to induce long-term changes in gene expression, synaptic function and behavioural responses. In this study, we evaluated the adult behavioural effects of perinatal environment enrichment in male and female mice (PEE), as...

Year Published: 2024Topics: Emotion, Pain, & Sentience, Environmental Enrichment, Rearing & Weaning, ReproductionAnimal Type: Mouse, Rodent

Citation: Silva-Almeida, C., Muniz, S. C. A., Jobim, C. M. N. et al. 2024. Perinatal environmental enrichment changes anxiety-like behaviours in mice and produces similar intergenerational benefits in offspring. Behavioural Brain Research 456, 114700.

Social environment enrichment alleviates anxiety-like behavior in mice: Involvement of the dopamine system

Rearing environment plays a vital role in maintaining physical and mental health of both animals and humans. Plenty of studies have proved that physical environment enrichment in adolescence has protective effects on emotion, social behavior, learning and memory deficits. However,...

Year Published: 2024Topics: Rearing & Weaning, Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Wang, Q., Wang, Y., Tian, Y. et al. 2024. Social environment enrichment alleviates anxiety-like behavior in mice: Involvement of the dopamine system. Behavioural Brain Research 456, 114687.

A pharmacokinetic and analgesic efficacy study of carprofen in female CD1 mice

The minimization of pain in research animals is a scientific and ethical necessity. Carprofen is commonly used for pain management in mice; however, some data suggest that the standard dosage of 5 mg/kg may not provide adequate analgesia after surgery....

Year Published: 2023Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: McKenna, B. A., Weaver, H. L., Kim, J. et al. 2023. A pharmacokinetic and analgesic efficacy study of carprofen in female CD1 mice. JAALAS 62(6), 545–552.